Uncoupling Protein 2 Ablation Exacerbates High-Salt Intake-Induced Vascular Dysfunction

Background Salt-induced vascular dysfunction in which underlying mechanisms involve reactive oxygen species (ROS)-mediated reduction of nitric oxide (NO) bioavailability has been well documented. Uncoupling protein 2 (UCP2) has been implicated in the vascular protection, specifically by decreasing R...

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Veröffentlicht in:	American journal of hypertension 2010-08, Vol.23 (8), p.822-828
Hauptverfasser:	Ma, Shuangtao, Ma, Liqun, Yang, Dachun, Luo, Zhidan, Hao, Xinzhong, Liu, Daoyan, Zhu, Zhiming
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Animals Aorta - drug effects Aorta - metabolism blood pressure Blood Pressure - drug effects high-salt diet hypertension Ion Channels - deficiency Mesenteric Arteries - drug effects Mice Mice, Inbred C57BL Mitochondrial Proteins - deficiency nitric oxide Nitric Oxide - metabolism Phenylephrine - pharmacology reactive oxygen species Sodium Chloride, Dietary - administration & dosage Sodium Chloride, Dietary - pharmacology Superoxides - metabolism Uncoupling Protein 2 vascular dysfunction Vasoconstriction - drug effects Vasodilation - drug effects
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