Regulation of NO-dependent acetylcholine relaxation by K + channels and the Na +–K + ATPase pump in porcine internal mammary artery

This study was designed to determine whether K + channels play a role in nitric oxide (NO)-dependent acetylcholine relaxation in porcine internal mammary artery (IMA). IMA segments were isolated and mounted in organ baths to record isometric tension. Acetylcholine-elicited vasodilation was abolished...

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Veröffentlicht in:	European journal of pharmacology 2010-09, Vol.641 (1), p.61-66
Hauptverfasser:	Pagán, Rosa María, Prieto, Dolores, Hernández, Medardo, Correa, Carlos, García-Sacristán, Albino, Benedito, Sara, Martínez, Ana Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Acetylcholine receptors (muscarinic) Acetylcholine relaxation Adenosinetriphosphatase Animals Arteries Atropine Biological and medical sciences Charybdotoxin Conductance Dose-Response Relationship, Drug Endothelin Endothelium Enzyme Activation - drug effects glibenclamide In Vitro Techniques Indomethacin Isometric K + channel Male Mammary Arteries - drug effects Mammary Arteries - enzymology Mammary Arteries - metabolism Mammary Arteries - physiology Medical sciences Miscellaneous Na-K + ATPase pump Nitric oxide Nitric Oxide - metabolism Ouabain Pharmacology. Drug treatments Porcine internal mammary artery Potassium channels (calcium-gated) Potassium channels (inwardly-rectifying) Potassium channels (voltage-gated) Potassium Channels - metabolism Reactive oxygen species Sodium-Potassium-Exchanging ATPase - metabolism Superoxide dismutase Swine Tetraethylammonium Vasodilation Vasodilation - drug effects
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