Antiproliferation of cardamonin is involved in mTOR on aortic smooth muscle cells in high fructose-induced insulin resistance rats

The objective of this study was to determine possible effects and potential mechanisms of cardamonin on improving insulin resistance and vascular proliferative lesions in the rat's model system. Fed with 60% fructose-enriched diet for 12 weeks, male Sprague–Dawley (SD) rats developed insulin re...

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Veröffentlicht in:	European journal of pharmacology 2010-09, Vol.641 (2), p.179-186
Hauptverfasser:	Liao, Qin, Shi, Dao-Hua, Zheng, Wei, Xu, Xiang-Jin, Yu, Ying-Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic - cytology Aorta, Thoracic - metabolism Aorta, Thoracic - ultrastructure Biological and medical sciences Cardamonin Carrier Proteins - metabolism Cell Proliferation - drug effects Chalcones - chemistry Chalcones - pharmacology Dose-Response Relationship, Drug Fructose Fructose - pharmacology Hyperinsulinism - drug therapy Hypoglycemic Agents - pharmacology Insulin - metabolism Insulin - pharmacology Insulin resistance Insulin Resistance - physiology Male Mammals Medical sciences Molecular Structure mTOR Muscle, Smooth, Vascular - pathology Muscle, Smooth, Vascular - ultrastructure Myocytes, Smooth Muscle - metabolism Pharmacology. Drug treatments Random Allocation Rapamycin Rat Rats Rats, Sprague-Dawley Ribosomal Protein S6 Kinases - metabolism Signal Transduction - drug effects Signal Transduction - physiology Sirolimus - pharmacology TOR Serine-Threonine Kinases - metabolism Vascular smooth muscle cell
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