Evidence for Differential Folding of Farnesyl Pyrophosphate in the Active Site of Aristolochene Synthase:  A Single-Point Mutation Converts Aristolochene Synthase into an (E)-β-Farnesene Synthase

Sesquiterpene cyclases, many of which share significant structural similarity, catalyze the cyclization reactions of the universal alicyclic precursor farnesyl pyrophosphate to produce more than 300 different hydrocarbon skeletons with high regio- and stereospecificity. The molecular basis of this e...

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Veröffentlicht in:	Biochemistry (Easton) 2003-07, Vol.42 (25), p.7741-7747
Hauptverfasser:	Deligeorgopoulou, Athina, Allemann, Rudolf K
Format:	Artikel
Sprache:	eng
Schlagworte:	Circular Dichroism Isomerases - genetics Isomerases - metabolism Penicillium - enzymology Point Mutation Polyisoprenyl Phosphates - metabolism Sesquiterpenes Structure-Activity Relationship
Online-Zugang:	Volltext
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