Continuous local intraarterial infusion of anticoagulants for microvascular free tissue transfer in primary reconstruction of the lower limb following resection of sarcoma
In free tissue transfers, preventing microvascular thrombosis is the first priority to achieve a successful result. Numerous protocols exist for preventing thrombosis postoperatively. We performed continuous local intraarterial infusion of anticoagulants in 11 patients undergoing wide resection of m...
Gespeichert in:
| Veröffentlicht in: | Microsurgery 2010-07, Vol.30 (5), p.376-379 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 379 |
|---|---|
| container_issue | 5 |
| container_start_page | 376 |
| container_title | Microsurgery |
| container_volume | 30 |
| creator | Saito, Akira Sawaizumi, Masayuki Imai, Tomohiro Matsumoto, Seiichi |
| description | In free tissue transfers, preventing microvascular thrombosis is the first priority to achieve a successful result. Numerous protocols exist for preventing thrombosis postoperatively. We performed continuous local intraarterial infusion of anticoagulants in 11 patients undergoing wide resection of malignant soft tissue tumors, followed by primary microvascular reconstruction in the lower limb. A catheter designed for epidural anesthesia was inserted into the femoral artery and connected to a syringe pump. A daily dose of 100 ml comprising 2,000 U of heparin and 40 μg of prostaglandin E1 was administered by means of continuous infusion for seven consecutive days as a standard regime. There were no cases of thrombosis during the continuous local intraarterial infusion of anticoagulants. There were no serious systemic complications. Although we have described limited cases and supporting data are lacking, we feel that this procedure might be useful for microsurgical reconstruction of the lower limb. © 2010 Wiley‐Liss, Inc. Microsurgery 30:376–379, 2010. |
| doi_str_mv | 10.1002/micr.20742 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733990071</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733990071</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4322-8daa66296c365a390d955b3569f3cb7b73861a93755247493c01344f21a2e0ee3</originalsourceid><addsrcrecordid>eNp9kcFu1DAQhi0EotvChQdAviEhpYztJF4fUaClVQGpoqrExXK8djEkcetxaPtMvGS93e0eOY3H-uYf_f8Q8obBIQPgH8Zg0yEHWfNnZMFALSsuG_6cLECKZcVg2eyRfcTfAKCUVC_JHgeolWL1gvzr4pTDNMcZ6RCtGWiYcjImZZfCY-dnDHGi0VNTSBvN1TyUF1IfE12vjn8N2vKXqE_O0RwQ51KSmdC7VBTodQqjSfc0ORsnzGm2eSuZf7my9rZgQxj7IjmULkxXBUW3o9AkG0fzirzwZkD3elsPyMXR5x_dl-rs-_FJ9_GssrXgvFqujGlbrlor2sYIBSvVNL1oWuWF7WVfQmmZUUI2Da9lrYQFJurac2a4A-fEAXm30b1O8WZ2mPUY0Lqh2HYlJy2FUApAskK-35AlBcTkvN5a1Qz0-jZ6HZB-vE2B325l5350qx36dIwCsA1wGwZ3_x8p_fWkO38SrTYzAbO7282Y9Ee3sljUl9-ONes-_WyO5Kk-Fw_9Sq1q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733990071</pqid></control><display><type>article</type><title>Continuous local intraarterial infusion of anticoagulants for microvascular free tissue transfer in primary reconstruction of the lower limb following resection of sarcoma</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Saito, Akira ; Sawaizumi, Masayuki ; Imai, Tomohiro ; Matsumoto, Seiichi</creator><creatorcontrib>Saito, Akira ; Sawaizumi, Masayuki ; Imai, Tomohiro ; Matsumoto, Seiichi</creatorcontrib><description>In free tissue transfers, preventing microvascular thrombosis is the first priority to achieve a successful result. Numerous protocols exist for preventing thrombosis postoperatively. We performed continuous local intraarterial infusion of anticoagulants in 11 patients undergoing wide resection of malignant soft tissue tumors, followed by primary microvascular reconstruction in the lower limb. A catheter designed for epidural anesthesia was inserted into the femoral artery and connected to a syringe pump. A daily dose of 100 ml comprising 2,000 U of heparin and 40 μg of prostaglandin E1 was administered by means of continuous infusion for seven consecutive days as a standard regime. There were no cases of thrombosis during the continuous local intraarterial infusion of anticoagulants. There were no serious systemic complications. Although we have described limited cases and supporting data are lacking, we feel that this procedure might be useful for microsurgical reconstruction of the lower limb. © 2010 Wiley‐Liss, Inc. Microsurgery 30:376–379, 2010.</description><identifier>ISSN: 0738-1085</identifier><identifier>EISSN: 1098-2752</identifier><identifier>DOI: 10.1002/micr.20742</identifier><identifier>PMID: 20049914</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Alprostadil - administration & dosage ; Anticoagulants - administration & dosage ; Child ; Cohort Studies ; Female ; Fibrinolytic Agents - administration & dosage ; Free Tissue Flaps ; Heparin - administration & dosage ; Humans ; Infusions, Intra-Arterial ; Leg ; Male ; Middle Aged ; Reconstructive Surgical Procedures ; Retrospective Studies ; Sarcoma - pathology ; Sarcoma - surgery ; Soft Tissue Neoplasms - pathology ; Soft Tissue Neoplasms - surgery ; Treatment Outcome ; Young Adult</subject><ispartof>Microsurgery, 2010-07, Vol.30 (5), p.376-379</ispartof><rights>Copyright © 2010 Wiley‐Liss, Inc.</rights><rights>(c) 2010 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4322-8daa66296c365a390d955b3569f3cb7b73861a93755247493c01344f21a2e0ee3</citedby><cites>FETCH-LOGICAL-c4322-8daa66296c365a390d955b3569f3cb7b73861a93755247493c01344f21a2e0ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmicr.20742$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmicr.20742$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20049914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saito, Akira</creatorcontrib><creatorcontrib>Sawaizumi, Masayuki</creatorcontrib><creatorcontrib>Imai, Tomohiro</creatorcontrib><creatorcontrib>Matsumoto, Seiichi</creatorcontrib><title>Continuous local intraarterial infusion of anticoagulants for microvascular free tissue transfer in primary reconstruction of the lower limb following resection of sarcoma</title><title>Microsurgery</title><addtitle>Microsurgery</addtitle><description>In free tissue transfers, preventing microvascular thrombosis is the first priority to achieve a successful result. Numerous protocols exist for preventing thrombosis postoperatively. We performed continuous local intraarterial infusion of anticoagulants in 11 patients undergoing wide resection of malignant soft tissue tumors, followed by primary microvascular reconstruction in the lower limb. A catheter designed for epidural anesthesia was inserted into the femoral artery and connected to a syringe pump. A daily dose of 100 ml comprising 2,000 U of heparin and 40 μg of prostaglandin E1 was administered by means of continuous infusion for seven consecutive days as a standard regime. There were no cases of thrombosis during the continuous local intraarterial infusion of anticoagulants. There were no serious systemic complications. Although we have described limited cases and supporting data are lacking, we feel that this procedure might be useful for microsurgical reconstruction of the lower limb. © 2010 Wiley‐Liss, Inc. Microsurgery 30:376–379, 2010.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Alprostadil - administration & dosage</subject><subject>Anticoagulants - administration & dosage</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Fibrinolytic Agents - administration & dosage</subject><subject>Free Tissue Flaps</subject><subject>Heparin - administration & dosage</subject><subject>Humans</subject><subject>Infusions, Intra-Arterial</subject><subject>Leg</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Reconstructive Surgical Procedures</subject><subject>Retrospective Studies</subject><subject>Sarcoma - pathology</subject><subject>Sarcoma - surgery</subject><subject>Soft Tissue Neoplasms - pathology</subject><subject>Soft Tissue Neoplasms - surgery</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0738-1085</issn><issn>1098-2752</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhi0EotvChQdAviEhpYztJF4fUaClVQGpoqrExXK8djEkcetxaPtMvGS93e0eOY3H-uYf_f8Q8obBIQPgH8Zg0yEHWfNnZMFALSsuG_6cLECKZcVg2eyRfcTfAKCUVC_JHgeolWL1gvzr4pTDNMcZ6RCtGWiYcjImZZfCY-dnDHGi0VNTSBvN1TyUF1IfE12vjn8N2vKXqE_O0RwQ51KSmdC7VBTodQqjSfc0ORsnzGm2eSuZf7my9rZgQxj7IjmULkxXBUW3o9AkG0fzirzwZkD3elsPyMXR5x_dl-rs-_FJ9_GssrXgvFqujGlbrlor2sYIBSvVNL1oWuWF7WVfQmmZUUI2Da9lrYQFJurac2a4A-fEAXm30b1O8WZ2mPUY0Lqh2HYlJy2FUApAskK-35AlBcTkvN5a1Qz0-jZ6HZB-vE2B325l5350qx36dIwCsA1wGwZ3_x8p_fWkO38SrTYzAbO7282Y9Ee3sljUl9-ONes-_WyO5Kk-Fw_9Sq1q</recordid><startdate>201007</startdate><enddate>201007</enddate><creator>Saito, Akira</creator><creator>Sawaizumi, Masayuki</creator><creator>Imai, Tomohiro</creator><creator>Matsumoto, Seiichi</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201007</creationdate><title>Continuous local intraarterial infusion of anticoagulants for microvascular free tissue transfer in primary reconstruction of the lower limb following resection of sarcoma</title><author>Saito, Akira ; Sawaizumi, Masayuki ; Imai, Tomohiro ; Matsumoto, Seiichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4322-8daa66296c365a390d955b3569f3cb7b73861a93755247493c01344f21a2e0ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Alprostadil - administration & dosage</topic><topic>Anticoagulants - administration & dosage</topic><topic>Child</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Fibrinolytic Agents - administration & dosage</topic><topic>Free Tissue Flaps</topic><topic>Heparin - administration & dosage</topic><topic>Humans</topic><topic>Infusions, Intra-Arterial</topic><topic>Leg</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Reconstructive Surgical Procedures</topic><topic>Retrospective Studies</topic><topic>Sarcoma - pathology</topic><topic>Sarcoma - surgery</topic><topic>Soft Tissue Neoplasms - pathology</topic><topic>Soft Tissue Neoplasms - surgery</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saito, Akira</creatorcontrib><creatorcontrib>Sawaizumi, Masayuki</creatorcontrib><creatorcontrib>Imai, Tomohiro</creatorcontrib><creatorcontrib>Matsumoto, Seiichi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microsurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saito, Akira</au><au>Sawaizumi, Masayuki</au><au>Imai, Tomohiro</au><au>Matsumoto, Seiichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Continuous local intraarterial infusion of anticoagulants for microvascular free tissue transfer in primary reconstruction of the lower limb following resection of sarcoma</atitle><jtitle>Microsurgery</jtitle><addtitle>Microsurgery</addtitle><date>2010-07</date><risdate>2010</risdate><volume>30</volume><issue>5</issue><spage>376</spage><epage>379</epage><pages>376-379</pages><issn>0738-1085</issn><eissn>1098-2752</eissn><abstract>In free tissue transfers, preventing microvascular thrombosis is the first priority to achieve a successful result. Numerous protocols exist for preventing thrombosis postoperatively. We performed continuous local intraarterial infusion of anticoagulants in 11 patients undergoing wide resection of malignant soft tissue tumors, followed by primary microvascular reconstruction in the lower limb. A catheter designed for epidural anesthesia was inserted into the femoral artery and connected to a syringe pump. A daily dose of 100 ml comprising 2,000 U of heparin and 40 μg of prostaglandin E1 was administered by means of continuous infusion for seven consecutive days as a standard regime. There were no cases of thrombosis during the continuous local intraarterial infusion of anticoagulants. There were no serious systemic complications. Although we have described limited cases and supporting data are lacking, we feel that this procedure might be useful for microsurgical reconstruction of the lower limb. © 2010 Wiley‐Liss, Inc. Microsurgery 30:376–379, 2010.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20049914</pmid><doi>10.1002/micr.20742</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0738-1085 |
| ispartof | Microsurgery, 2010-07, Vol.30 (5), p.376-379 |
| issn | 0738-1085 1098-2752 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_733990071 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adolescent Adult Aged Alprostadil - administration & dosage Anticoagulants - administration & dosage Child Cohort Studies Female Fibrinolytic Agents - administration & dosage Free Tissue Flaps Heparin - administration & dosage Humans Infusions, Intra-Arterial Leg Male Middle Aged Reconstructive Surgical Procedures Retrospective Studies Sarcoma - pathology Sarcoma - surgery Soft Tissue Neoplasms - pathology Soft Tissue Neoplasms - surgery Treatment Outcome Young Adult |
| title | Continuous local intraarterial infusion of anticoagulants for microvascular free tissue transfer in primary reconstruction of the lower limb following resection of sarcoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T02%3A51%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Continuous%20local%20intraarterial%20infusion%20of%20anticoagulants%20for%20microvascular%20free%20tissue%20transfer%20in%20primary%20reconstruction%20of%20the%20lower%20limb%20following%20resection%20of%20sarcoma&rft.jtitle=Microsurgery&rft.au=Saito,%20Akira&rft.date=2010-07&rft.volume=30&rft.issue=5&rft.spage=376&rft.epage=379&rft.pages=376-379&rft.issn=0738-1085&rft.eissn=1098-2752&rft_id=info:doi/10.1002/micr.20742&rft_dat=%3Cproquest_cross%3E733990071%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733990071&rft_id=info:pmid/20049914&rfr_iscdi=true |