Noninvasive Evaluation of Abdominal Fat and Liver Changes Following Progressive Weight Loss in Severely Obese Patients Treated with Laparoscopic Gastric Bypass
Background Obesity is a chronic complex disease, consequence of an unbalance between energy intake and expenditure and of the interaction between predisposing genotype and facilitating environmental factors. The aim of the study was to evaluate body composition, abdominal fat, and metabolic changes...
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| Veröffentlicht in: | Obesity surgery 2009-12, Vol.19 (12), p.1664-1671 |
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| creator | del Genio, Federica del Genio, Gianmattia De Sio, Ilario Marra, Maurizio Alfonsi, Lucia Finelli, Carmine Contaldo, Franco Pasanisi, Fabrizio |
| description | Background
Obesity is a chronic complex disease, consequence of an unbalance between energy intake and expenditure and of the interaction between predisposing genotype and facilitating environmental factors. The aim of the study was to evaluate body composition, abdominal fat, and metabolic changes in a group of severely obese patients before and after laparoscopic gastric bypass (LGBP) at standardized (10% and 25%) total weight loss.
Methods
Twenty-eight patients (14 M, 14 F; age 41.71 ± 6.9 years; body mass index (BMI) 49.76 ± 5.8 kg/m
2
) were treated with laparoscopic gastric bypass. All evaluations before surgery and after achieving ~10% and ~25% weight loss (WL). Body composition was assessed by bioimpedance analysis; resting metabolic rate (RMR) was measured by indirect calorimetry.
Results
Body weight, BMI, and waist circumference significantly decreased at 10% and 25% WL. We observed a significant reduction of both RMR (2,492 ± 388 at entry vs. 2,098 ± 346.6 at 10% WL vs. 2,035 ± 312 kcal per 24 h at 25% WL,
p
= 0.001 vs. baseline) as well as of RMR corrected for fat-free mass (FFM; 35.7 ± 6.7 vs. 34.9 ± 9.0 at 10% WL vs. 33.5 ± 5.4 at 25% WL kilocalorie per kilogram FFM × 24 h,
p
= 0.041 vs. baseline). Body composition analysis showed a relative increase in FFM and a reduction of fat mass at 25% WL. A significant reduction in blood glucose, insulin, homeostasis model assessment index was observed. Ultrasonography showed a marked decrease in the signs of hepatic steatosis.
Conclusion
In conclusion, our study confirms that LGBP is a safe procedure in well-selected severely obese patients and has early favorable effects on both metabolic parameters and body composition. Longer-term observations are required for in-depth evaluation of body composition changes. |
| doi_str_mv | 10.1007/s11695-009-9891-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733989839</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733989839</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-f39b14487cedace8b0d7cb8f2bd5107ec09903796f4630c0efca75ca781c6b9a3</originalsourceid><addsrcrecordid>eNp1kcFu1DAQhiMEokvhAbggiwunwNjexPGxrLoFKaKVKOJoOc5k11U2Dp5k230aXhWXXakSEgdrDv7-3_J8WfaWw0cOoD4R56UucgCd60rz_OFZtuAKqhyWonqeLUCXkFdayLPsFdEdgOClEC-zM64LUQoFi-z3tzD4YW_J75Fd7m0_28mHgYWOXTRt2PnB9mxtJ2aHltUJimy1tcMGia1D34d7P2zYTQybiPS34yf6zXZidSBifmDfMUWwP7DrBgnZTWrHYSJ2G9FO2LJ7P21ZbUcbA7kweseuLE0xzc-H0RK9zl50tid8c5rn2Y_15e3qS15fX31dXdS5kwqmvJO64ctlpRy21mHVQKtcU3WiaQsOCh1oDVLpsluWEhxg56wq0qm4Kxtt5Xn24dg7xvBrRprMzpPDvrcDhpmMkjKtuJI6ke__Ie_CHNOayAghBecaigTxI-TSvyhiZ8bodzYeDAfz6M4c3Znkzjy6Mw8p8-5UPDc7bJ8SJ1kJEEeA0lVSEJ9e_n_rH-GxqCY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>223211905</pqid></control><display><type>article</type><title>Noninvasive Evaluation of Abdominal Fat and Liver Changes Following Progressive Weight Loss in Severely Obese Patients Treated with Laparoscopic Gastric Bypass</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>del Genio, Federica ; del Genio, Gianmattia ; De Sio, Ilario ; Marra, Maurizio ; Alfonsi, Lucia ; Finelli, Carmine ; Contaldo, Franco ; Pasanisi, Fabrizio</creator><creatorcontrib>del Genio, Federica ; del Genio, Gianmattia ; De Sio, Ilario ; Marra, Maurizio ; Alfonsi, Lucia ; Finelli, Carmine ; Contaldo, Franco ; Pasanisi, Fabrizio</creatorcontrib><description>Background
Obesity is a chronic complex disease, consequence of an unbalance between energy intake and expenditure and of the interaction between predisposing genotype and facilitating environmental factors. The aim of the study was to evaluate body composition, abdominal fat, and metabolic changes in a group of severely obese patients before and after laparoscopic gastric bypass (LGBP) at standardized (10% and 25%) total weight loss.
Methods
Twenty-eight patients (14 M, 14 F; age 41.71 ± 6.9 years; body mass index (BMI) 49.76 ± 5.8 kg/m
2
) were treated with laparoscopic gastric bypass. All evaluations before surgery and after achieving ~10% and ~25% weight loss (WL). Body composition was assessed by bioimpedance analysis; resting metabolic rate (RMR) was measured by indirect calorimetry.
Results
Body weight, BMI, and waist circumference significantly decreased at 10% and 25% WL. We observed a significant reduction of both RMR (2,492 ± 388 at entry vs. 2,098 ± 346.6 at 10% WL vs. 2,035 ± 312 kcal per 24 h at 25% WL,
p
= 0.001 vs. baseline) as well as of RMR corrected for fat-free mass (FFM; 35.7 ± 6.7 vs. 34.9 ± 9.0 at 10% WL vs. 33.5 ± 5.4 at 25% WL kilocalorie per kilogram FFM × 24 h,
p
= 0.041 vs. baseline). Body composition analysis showed a relative increase in FFM and a reduction of fat mass at 25% WL. A significant reduction in blood glucose, insulin, homeostasis model assessment index was observed. Ultrasonography showed a marked decrease in the signs of hepatic steatosis.
Conclusion
In conclusion, our study confirms that LGBP is a safe procedure in well-selected severely obese patients and has early favorable effects on both metabolic parameters and body composition. Longer-term observations are required for in-depth evaluation of body composition changes.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-009-9891-x</identifier><identifier>PMID: 19526270</identifier><language>eng</language><publisher>New York: Springer New York</publisher><subject>Abdomen ; Abdominal Fat - physiology ; Adult ; Anthropometry - methods ; Body fat ; Body Mass Index ; Female ; Follow-Up Studies ; Gastrointestinal surgery ; Gastroplasty ; Humans ; Laparoscopy ; Liver ; Liver - physiology ; Male ; Medicine ; Medicine & Public Health ; Obesity ; Obesity, Morbid - surgery ; Surgery ; Treatment Outcome ; Ultrasonic imaging ; Weight ; Weight Loss</subject><ispartof>Obesity surgery, 2009-12, Vol.19 (12), p.1664-1671</ispartof><rights>Springer Science + Business Media, LLC 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-f39b14487cedace8b0d7cb8f2bd5107ec09903796f4630c0efca75ca781c6b9a3</citedby><cites>FETCH-LOGICAL-c370t-f39b14487cedace8b0d7cb8f2bd5107ec09903796f4630c0efca75ca781c6b9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-009-9891-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-009-9891-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19526270$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>del Genio, Federica</creatorcontrib><creatorcontrib>del Genio, Gianmattia</creatorcontrib><creatorcontrib>De Sio, Ilario</creatorcontrib><creatorcontrib>Marra, Maurizio</creatorcontrib><creatorcontrib>Alfonsi, Lucia</creatorcontrib><creatorcontrib>Finelli, Carmine</creatorcontrib><creatorcontrib>Contaldo, Franco</creatorcontrib><creatorcontrib>Pasanisi, Fabrizio</creatorcontrib><title>Noninvasive Evaluation of Abdominal Fat and Liver Changes Following Progressive Weight Loss in Severely Obese Patients Treated with Laparoscopic Gastric Bypass</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Background
Obesity is a chronic complex disease, consequence of an unbalance between energy intake and expenditure and of the interaction between predisposing genotype and facilitating environmental factors. The aim of the study was to evaluate body composition, abdominal fat, and metabolic changes in a group of severely obese patients before and after laparoscopic gastric bypass (LGBP) at standardized (10% and 25%) total weight loss.
Methods
Twenty-eight patients (14 M, 14 F; age 41.71 ± 6.9 years; body mass index (BMI) 49.76 ± 5.8 kg/m
2
) were treated with laparoscopic gastric bypass. All evaluations before surgery and after achieving ~10% and ~25% weight loss (WL). Body composition was assessed by bioimpedance analysis; resting metabolic rate (RMR) was measured by indirect calorimetry.
Results
Body weight, BMI, and waist circumference significantly decreased at 10% and 25% WL. We observed a significant reduction of both RMR (2,492 ± 388 at entry vs. 2,098 ± 346.6 at 10% WL vs. 2,035 ± 312 kcal per 24 h at 25% WL,
p
= 0.001 vs. baseline) as well as of RMR corrected for fat-free mass (FFM; 35.7 ± 6.7 vs. 34.9 ± 9.0 at 10% WL vs. 33.5 ± 5.4 at 25% WL kilocalorie per kilogram FFM × 24 h,
p
= 0.041 vs. baseline). Body composition analysis showed a relative increase in FFM and a reduction of fat mass at 25% WL. A significant reduction in blood glucose, insulin, homeostasis model assessment index was observed. Ultrasonography showed a marked decrease in the signs of hepatic steatosis.
Conclusion
In conclusion, our study confirms that LGBP is a safe procedure in well-selected severely obese patients and has early favorable effects on both metabolic parameters and body composition. Longer-term observations are required for in-depth evaluation of body composition changes.</description><subject>Abdomen</subject><subject>Abdominal Fat - physiology</subject><subject>Adult</subject><subject>Anthropometry - methods</subject><subject>Body fat</subject><subject>Body Mass Index</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastrointestinal surgery</subject><subject>Gastroplasty</subject><subject>Humans</subject><subject>Laparoscopy</subject><subject>Liver</subject><subject>Liver - physiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obesity</subject><subject>Obesity, Morbid - surgery</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Ultrasonic imaging</subject><subject>Weight</subject><subject>Weight Loss</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kcFu1DAQhiMEokvhAbggiwunwNjexPGxrLoFKaKVKOJoOc5k11U2Dp5k230aXhWXXakSEgdrDv7-3_J8WfaWw0cOoD4R56UucgCd60rz_OFZtuAKqhyWonqeLUCXkFdayLPsFdEdgOClEC-zM64LUQoFi-z3tzD4YW_J75Fd7m0_28mHgYWOXTRt2PnB9mxtJ2aHltUJimy1tcMGia1D34d7P2zYTQybiPS34yf6zXZidSBifmDfMUWwP7DrBgnZTWrHYSJ2G9FO2LJ7P21ZbUcbA7kweseuLE0xzc-H0RK9zl50tid8c5rn2Y_15e3qS15fX31dXdS5kwqmvJO64ctlpRy21mHVQKtcU3WiaQsOCh1oDVLpsluWEhxg56wq0qm4Kxtt5Xn24dg7xvBrRprMzpPDvrcDhpmMkjKtuJI6ke__Ie_CHNOayAghBecaigTxI-TSvyhiZ8bodzYeDAfz6M4c3Znkzjy6Mw8p8-5UPDc7bJ8SJ1kJEEeA0lVSEJ9e_n_rH-GxqCY</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>del Genio, Federica</creator><creator>del Genio, Gianmattia</creator><creator>De Sio, Ilario</creator><creator>Marra, Maurizio</creator><creator>Alfonsi, Lucia</creator><creator>Finelli, Carmine</creator><creator>Contaldo, Franco</creator><creator>Pasanisi, Fabrizio</creator><general>Springer New York</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20091201</creationdate><title>Noninvasive Evaluation of Abdominal Fat and Liver Changes Following Progressive Weight Loss in Severely Obese Patients Treated with Laparoscopic Gastric Bypass</title><author>del Genio, Federica ; del Genio, Gianmattia ; De Sio, Ilario ; Marra, Maurizio ; Alfonsi, Lucia ; Finelli, Carmine ; Contaldo, Franco ; Pasanisi, Fabrizio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-f39b14487cedace8b0d7cb8f2bd5107ec09903796f4630c0efca75ca781c6b9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Abdomen</topic><topic>Abdominal Fat - physiology</topic><topic>Adult</topic><topic>Anthropometry - methods</topic><topic>Body fat</topic><topic>Body Mass Index</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastrointestinal surgery</topic><topic>Gastroplasty</topic><topic>Humans</topic><topic>Laparoscopy</topic><topic>Liver</topic><topic>Liver - physiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obesity</topic><topic>Obesity, Morbid - surgery</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><topic>Ultrasonic imaging</topic><topic>Weight</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>del Genio, Federica</creatorcontrib><creatorcontrib>del Genio, Gianmattia</creatorcontrib><creatorcontrib>De Sio, Ilario</creatorcontrib><creatorcontrib>Marra, Maurizio</creatorcontrib><creatorcontrib>Alfonsi, Lucia</creatorcontrib><creatorcontrib>Finelli, Carmine</creatorcontrib><creatorcontrib>Contaldo, Franco</creatorcontrib><creatorcontrib>Pasanisi, Fabrizio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>del Genio, Federica</au><au>del Genio, Gianmattia</au><au>De Sio, Ilario</au><au>Marra, Maurizio</au><au>Alfonsi, Lucia</au><au>Finelli, Carmine</au><au>Contaldo, Franco</au><au>Pasanisi, Fabrizio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Noninvasive Evaluation of Abdominal Fat and Liver Changes Following Progressive Weight Loss in Severely Obese Patients Treated with Laparoscopic Gastric Bypass</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>19</volume><issue>12</issue><spage>1664</spage><epage>1671</epage><pages>1664-1671</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Background
Obesity is a chronic complex disease, consequence of an unbalance between energy intake and expenditure and of the interaction between predisposing genotype and facilitating environmental factors. The aim of the study was to evaluate body composition, abdominal fat, and metabolic changes in a group of severely obese patients before and after laparoscopic gastric bypass (LGBP) at standardized (10% and 25%) total weight loss.
Methods
Twenty-eight patients (14 M, 14 F; age 41.71 ± 6.9 years; body mass index (BMI) 49.76 ± 5.8 kg/m
2
) were treated with laparoscopic gastric bypass. All evaluations before surgery and after achieving ~10% and ~25% weight loss (WL). Body composition was assessed by bioimpedance analysis; resting metabolic rate (RMR) was measured by indirect calorimetry.
Results
Body weight, BMI, and waist circumference significantly decreased at 10% and 25% WL. We observed a significant reduction of both RMR (2,492 ± 388 at entry vs. 2,098 ± 346.6 at 10% WL vs. 2,035 ± 312 kcal per 24 h at 25% WL,
p
= 0.001 vs. baseline) as well as of RMR corrected for fat-free mass (FFM; 35.7 ± 6.7 vs. 34.9 ± 9.0 at 10% WL vs. 33.5 ± 5.4 at 25% WL kilocalorie per kilogram FFM × 24 h,
p
= 0.041 vs. baseline). Body composition analysis showed a relative increase in FFM and a reduction of fat mass at 25% WL. A significant reduction in blood glucose, insulin, homeostasis model assessment index was observed. Ultrasonography showed a marked decrease in the signs of hepatic steatosis.
Conclusion
In conclusion, our study confirms that LGBP is a safe procedure in well-selected severely obese patients and has early favorable effects on both metabolic parameters and body composition. Longer-term observations are required for in-depth evaluation of body composition changes.</abstract><cop>New York</cop><pub>Springer New York</pub><pmid>19526270</pmid><doi>10.1007/s11695-009-9891-x</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Abdomen Abdominal Fat - physiology Adult Anthropometry - methods Body fat Body Mass Index Female Follow-Up Studies Gastrointestinal surgery Gastroplasty Humans Laparoscopy Liver Liver - physiology Male Medicine Medicine & Public Health Obesity Obesity, Morbid - surgery Surgery Treatment Outcome Ultrasonic imaging Weight Weight Loss |
| title | Noninvasive Evaluation of Abdominal Fat and Liver Changes Following Progressive Weight Loss in Severely Obese Patients Treated with Laparoscopic Gastric Bypass |
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