Postinfarct Treatment With Oxytocin Improves Cardiac Function and Remodeling via Activating Cell-survival Signals and Angiogenesis

BACKGROUND:We investigated whether postinfarct treatment with oxytocin (OT) improves left ventricular (LV) function and remodeling via cardiac repair of myocardial ischemia-reperfusion injury. METHODS AND RESULTS:Experiments were performed with 30 minutes of coronary occlusion and 2 or 14 days of re...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2009-12, Vol.54 (6), p.510-519
Hauptverfasser:	Kobayashi, Hiroyuki, Yasuda, Shinji, Bao, Narentuoya, Iwasa, Masamitsu, Kawamura, Itta, Yamada, Yoshihisa, Yamaki, Takahiko, Sumi, Syohei, Ushikoshi, Hiroaki, Nishigaki, Kazuhiko, Takemura, Genzou, Fujiwara, Takako, Fujiwara, Hisayoshi, Minatoguchi, Shinya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure - drug effects Blood Pressure - physiology Cyclin D1 - metabolism Disease Models, Animal Echocardiography Extracellular Signal-Regulated MAP Kinases - metabolism Heart - drug effects Heart - physiopathology Heart Rate - drug effects Heart Rate - physiology Male Matrix Metalloproteinase 1 - metabolism Microvessels - anatomy & histology Microvessels - metabolism Myocardial Infarction - drug therapy Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardium - metabolism Myocardium - pathology Neovascularization, Physiologic - drug effects Nitric Oxide Synthase Type III - metabolism Oxytocin - pharmacology Oxytocin - therapeutic use Phosphorylation - drug effects Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Proto-Oncogene Proteins c-akt - metabolism Rabbits Receptors, Oxytocin - metabolism Signal Transduction - drug effects STAT3 Transcription Factor - metabolism Stroke Volume - drug effects Stroke Volume - physiology Vascular Endothelial Growth Factor A - metabolism Ventricular Dysfunction, Left - drug therapy Ventricular Dysfunction, Left - pathology Ventricular Dysfunction, Left - physiopathology Ventricular Function, Left - drug effects Ventricular Function, Left - physiology Ventricular Remodeling - drug effects Ventricular Remodeling - physiology
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