In Vitro to In Vivo Comparison of the Substrate Characteristics of Sorafenib Tosylate toward P-Glycoprotein

Sorafenib (Nexavar) is a novel oral Raf kinase and vascular endothelial growth factor receptor inhibitor. Most anticancer drugs are substrates for ATP-binding cassette efflux pumps especially for P-glycoprotein (P-gp). To evaluate the influence of P-gp on the pharmacokinetics of sorafenib substrate...

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Veröffentlicht in:	Drug metabolism and disposition 2010-08, Vol.38 (8), p.1341-1346
Hauptverfasser:	Gnoth, M.J., Sandmann, S., Engel, K., Radtke, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Arrhythmia Agents - metabolism Anti-Arrhythmia Agents - pharmacokinetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism ATP-Binding Cassette, Sub-Family B, Member 1 - pharmacokinetics Benzenesulfonates - blood Benzenesulfonates - metabolism Benzenesulfonates - pharmacokinetics Biological and medical sciences Brain - metabolism Caco-2 Cells Digoxin - metabolism Digoxin - pharmacokinetics Humans LLC-PK1 Cells Male Medical sciences Mice Mice, Knockout Niacinamide - analogs & derivatives Permeability Pharmacology. Drug treatments Phenylurea Compounds Protein Kinase Inhibitors - blood Protein Kinase Inhibitors - metabolism Protein Kinase Inhibitors - pharmacokinetics Pyridines - blood Pyridines - metabolism Pyridines - pharmacokinetics Swine
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