Neural stem cells adopt tumorigenic properties by constitutively activated NF-kappaB and subsequent VEGF up-regulation

One of the challenges in stem cell research is to avoid transformation during cultivation. We studied high passage subventricular zone derived neural stem cells (NSCs) cultures of adult rats in the absence of growth factors epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF). We...

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Veröffentlicht in:	Stem cells and development 2010-07, Vol.19 (7), p.999-1015
Hauptverfasser:	Kaus, Aljoscha, Widera, Darius, Kassmer, Susannah, Peter, Jan, Zaenker, Kurt, Kaltschmidt, Christian, Kaltschmidt, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - metabolism Cell Culture Techniques Cell Differentiation Cell Proliferation Cells, Cultured Humans Microarray Analysis Neurons - cytology Neurons - physiology NF-kappa B - metabolism Phenotype Rats Rats, Wistar Stem Cells - cytology Stem Cells - physiology Tumor Suppressor Protein p53 - metabolism Up-Regulation Vascular Endothelial Growth Factor A - metabolism
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