The pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma

Antiapoptotic Bcl-2 family members suppress both apoptosis and autophagy and are of major importance for therapy resistance of malignant gliomas. To target these molecules, we used BH3 mimetics and analyzed the molecular mechanisms of cell death induced thereby. Glioma cells displayed only limited s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular cancer research 2010-07, Vol.8 (7), p.1002-1016
Hauptverfasser:	Voss, Valerie, Senft, Christian, Lang, Verena, Ronellenfitsch, Michael W, Steinbach, Joachim P, Seifert, Volker, Kögel, Donat
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Autophagy - drug effects Caspases - metabolism Cell Line, Tumor Dacarbazine - analogs & derivatives Dacarbazine - pharmacology DNA Modification Methylases - metabolism DNA Repair Enzymes - metabolism Enzyme Activation Glioma - drug therapy Glioma - genetics Glioma - metabolism Glioma - pathology Gossypol - pharmacology Humans Mitochondria - drug effects Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors Rats Rats, Wistar Signal Transduction - drug effects Transfection Tumor Suppressor Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!