Reduced cyclic stretch, endothelial dysfunction, and oxidative stress: an ex vivo model

Abstract Background The objective of this study was to investigate whether reduction of cyclic circumferential stretch will impair endothelial function and elevate basal levels of oxidative stress, both known risk factors linked to cardiovascular disease. Methods Ex vivo and in vitro models were use...

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Veröffentlicht in:	Cardiovascular pathology 2010-07, Vol.19 (4), p.e91-e98
Hauptverfasser:	Thacher, Tyler, Gambillara, Veronica, da Silva, Rafaela F, Silacci, Paolo, Stergiopulos, Nikos
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Animals Arterial compliance Bradykinin - drug effects Carotid Artery, Internal - drug effects Carotid Artery, Internal - physiology Cells, Cultured Compliance - drug effects Compliance - physiology Endothelial dysfunction Endothelium, Vascular - cytology Endothelium, Vascular - drug effects Endothelium, Vascular - physiology eNOS Mechanotransduction, Cellular - drug effects Mechanotransduction, Cellular - physiology Models, Animal NADPH Oxidases - biosynthesis Nitric Oxide Synthase Type III - metabolism Oxidative Stress Pathology Pulsatile Flow Reactive Oxygen Species - metabolism Shear Strength - drug effects Shear Strength - physiology Stress, Mechanical Swine Tensile Strength - drug effects Tensile Strength - physiology Up-Regulation Vasodilation - drug effects Vasodilation - physiology
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