Exploring the mechanism of endothelial involvement in acidosis-induced vasodilatation of aortic tissues from normal and diabetic rats

Acidosis modulates physiologic and pathophysiologic processes but the mechanism of acidotic vasodilatation remains unclear. We therefore explored this in aortic rings from normal and streptozotocin-induced diabetic Sprague–Dawley rats. Phenylephrine (PE)-induced contraction in endothelium-intact and...

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Veröffentlicht in:	European journal of pharmacology 2010-09, Vol.642 (1), p.99-106
Hauptverfasser:	Yeo, Jian Loong, Tan, Boris Teng Chuan, Achike, Francis I.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine - pharmacology Acidosis Acidosis - physiopathology Animals Aorta - drug effects Aorta - pathology Aorta - physiopathology Barium Compounds - pharmacology Biological and medical sciences Chlorides - pharmacology Diabetes mellitus Diabetes Mellitus - pathology Diabetes Mellitus - physiopathology Diabetes. Impaired glucose tolerance EDRF Endocrine pancreas. Apud cells (diseases) Endocrinopathies Endothelium, Vascular - drug effects Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology Etiopathogenesis. Screening. Investigations. Target tissue resistance Glucose Clamp Technique Glyburide - pharmacology Indomethacin - pharmacology Male Medical sciences Methylene Blue - pharmacology NG-Nitroarginine Methyl Ester - pharmacology Peptides - pharmacology Pharmacology. Drug treatments Potassium channels Rats Rats, Sprague-Dawley Tetraethylammonium - pharmacology Vasodilation - drug effects
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