Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy

In most patients with hypertensive nephropathy and low glomerular filtration rate (GFR), the kidney function progressively declines despite the adequate control of the hypertension with angiotensin-converting enzyme inhibition. Previously we found that 2 years of oral sodium citrate slowed GFR decli...

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Veröffentlicht in:	Kidney international 2010-08, Vol.78 (3), p.303-309
Hauptverfasser:	Mahajan, Ashutosh, Simoni, Jan, Sheather, Simon J., Broglio, Kristine R., Rajab, M.H., Wesson, Donald E.
Format:	Artikel
Sprache:	eng
Schlagworte:	acidosis Administration, Oral Adult albuminuria Albuminuria - drug therapy Albuminuria - physiopathology Angiotensin-Converting Enzyme Inhibitors - pharmacology Angiotensin-Converting Enzyme Inhibitors - therapeutic use Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system chronic kidney disease chronic metabolic acidosis Cystatin C - blood Double-Blind Method Drug Therapy, Combination Female Glomerular Filtration Rate - drug effects Humans hypertension Hypertension - complications Hypertension - drug therapy Hypertension - physiopathology Kidney - drug effects Kidney - physiopathology Kidney Diseases - drug therapy Kidney Diseases - etiology Kidney Diseases - physiopathology Kidneys Longitudinal Studies Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Prospective Studies Sodium Bicarbonate - administration & dosage Sodium Bicarbonate - pharmacology Urinary system involvement in other diseases. Miscellaneous
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