Role of 11C-choline PET/CT in the restaging of prostate cancer patients showing a single lesion on bone scintigraphy
Aim To assess the utility of 11 C-choline PET/CT in the restaging of prostate cancer (PC) patients who showed a single finding on bone scintigraphy (BS) that was classified as equivocal or suspected for metastatic lesion. Materials and methods A total of 25 PC patients with biochemical failure (mean...
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| Veröffentlicht in: | Annals of nuclear medicine 2010-07, Vol.24 (6), p.485-492 |
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| creator | Fuccio, Chiara Castellucci, Paolo Schiavina, Riccardo Santi, Ivan Allegri, Vincenzo Pettinato, Vincenzina Boschi, Stefano Martorana, Giuseppe Al-Nahhas, Adil Rubello, Domenico Fanti, Stefano |
| description | Aim
To assess the utility of
11
C-choline PET/CT in the restaging of prostate cancer (PC) patients who showed a single finding on bone scintigraphy (BS) that was classified as equivocal or suspected for metastatic lesion.
Materials and methods
A total of 25 PC patients with biochemical failure (mean PSA value 11.1 ng/mL; median value 6.3 ng/mL; range 0.2–37.7 ng/mL) after primary treatment were included in this retrospective study. All of them showed a single lesion on BS reported as suspected for metastatic lesion or as equivocal finding. Patients underwent
11
C-choline PET/CT within 1–4 months from BS. Validation was established by follow-up for at least 6 months.
Results
On the basis of biopsy confirmation and/or 6-month follow-up, 22 of 25 patients were classified as positive for the presence of metastatic bone lesions: 13 with a single lesion and 9 with multiple lesions.
11
C-choline PET/CT was positive in 19/25 patients and, on a lesion basis, it showed 50 positive findings. BS results were confirmed in 8/25 (32%) patients.
11
C-choline PET/CT detected multiple sites of relapse in 11/25 (44%) patients: in 2/11, a single bone lesion associated with other extraosseous sites of relapse; in 6/11, multiple bone lesions; in 3/11, multiple bone lesions and other extraosseous localizations. Finally, 6/25 patients were negative on
11
C-choline PET/CT. In 3/6 patients, an osteoblastic lesion was seen on CT attenuation correction images (PET false negative; BS true positive), while in 3/6 patients only findings suggestive of the presence of degenerative disease were found (PET true negative; BS false positive). On a patient basis,
11
C-choline PET/CT showed a diagnostic sensitivity of 86% (19/22) and a specificity of 100% (19/19).
Conclusions
In our study,
11
C-choline PET/CT detected unknown lesions in 11/25 patients. Patients with a single equivocal finding on BS could have important additional information from
11
C-choline PET/CT study, especially in the detection of additional metastases, to choose an appropriate treatment. |
| doi_str_mv | 10.1007/s12149-010-0390-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733982942</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733982942</sourcerecordid><originalsourceid>FETCH-LOGICAL-c239x-14a970c1cd68f322f25bfb28574737461cda38bc60cb74f301907517116d99aa3</originalsourceid><addsrcrecordid>eNp1kcFqGzEQhkVJaZy0D9BLEbn0pGRGklerYzBpEgi0FPcstLLWVlhLjrQmzttXi9MWAoWBYZhvfs3oJ-QzwiUCqKuCHKVmgMBAaGCHd2SGbSNZI4U4ITPQKJnCVp2Ss1IeAXg7b_kHcsphLqXgYkbGn2nwNPUUccHcJg0hevrjZnm1WNIQ6bjxNPsy2nWI6wnb5VSr0VNno_OZ7uwYfBwLLZv0PDGWlpqq5uBLSJHW6FLVLC7EMayz3W1ePpL3vR2K__Saz8mvbzfLxR17-H57v7h-YI4LfWAorVbg0K2athec93ze9V29QUkllGxqw4q2cw24TsleAGpQc1SIzUpra8U5-XrUrVs_7esZZhuK88Ngo0_7YpQQuuVa8kpevCEf0z7HupxpJkFoG1EhPEKufkLJvje7HLY2vxgEMxlijoaYaoiZDDGHOvPlVXjfbf3q78QfByrAj0Cprbj2-d_L_1f9DQeClSA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>617110863</pqid></control><display><type>article</type><title>Role of 11C-choline PET/CT in the restaging of prostate cancer patients showing a single lesion on bone scintigraphy</title><source>MEDLINE</source><source>Springer Online Journals Complete</source><creator>Fuccio, Chiara ; Castellucci, Paolo ; Schiavina, Riccardo ; Santi, Ivan ; Allegri, Vincenzo ; Pettinato, Vincenzina ; Boschi, Stefano ; Martorana, Giuseppe ; Al-Nahhas, Adil ; Rubello, Domenico ; Fanti, Stefano</creator><creatorcontrib>Fuccio, Chiara ; Castellucci, Paolo ; Schiavina, Riccardo ; Santi, Ivan ; Allegri, Vincenzo ; Pettinato, Vincenzina ; Boschi, Stefano ; Martorana, Giuseppe ; Al-Nahhas, Adil ; Rubello, Domenico ; Fanti, Stefano</creatorcontrib><description>Aim
To assess the utility of
11
C-choline PET/CT in the restaging of prostate cancer (PC) patients who showed a single finding on bone scintigraphy (BS) that was classified as equivocal or suspected for metastatic lesion.
Materials and methods
A total of 25 PC patients with biochemical failure (mean PSA value 11.1 ng/mL; median value 6.3 ng/mL; range 0.2–37.7 ng/mL) after primary treatment were included in this retrospective study. All of them showed a single lesion on BS reported as suspected for metastatic lesion or as equivocal finding. Patients underwent
11
C-choline PET/CT within 1–4 months from BS. Validation was established by follow-up for at least 6 months.
Results
On the basis of biopsy confirmation and/or 6-month follow-up, 22 of 25 patients were classified as positive for the presence of metastatic bone lesions: 13 with a single lesion and 9 with multiple lesions.
11
C-choline PET/CT was positive in 19/25 patients and, on a lesion basis, it showed 50 positive findings. BS results were confirmed in 8/25 (32%) patients.
11
C-choline PET/CT detected multiple sites of relapse in 11/25 (44%) patients: in 2/11, a single bone lesion associated with other extraosseous sites of relapse; in 6/11, multiple bone lesions; in 3/11, multiple bone lesions and other extraosseous localizations. Finally, 6/25 patients were negative on
11
C-choline PET/CT. In 3/6 patients, an osteoblastic lesion was seen on CT attenuation correction images (PET false negative; BS true positive), while in 3/6 patients only findings suggestive of the presence of degenerative disease were found (PET true negative; BS false positive). On a patient basis,
11
C-choline PET/CT showed a diagnostic sensitivity of 86% (19/22) and a specificity of 100% (19/19).
Conclusions
In our study,
11
C-choline PET/CT detected unknown lesions in 11/25 patients. Patients with a single equivocal finding on BS could have important additional information from
11
C-choline PET/CT study, especially in the detection of additional metastases, to choose an appropriate treatment.</description><identifier>ISSN: 0914-7187</identifier><identifier>EISSN: 1864-6433</identifier><identifier>DOI: 10.1007/s12149-010-0390-x</identifier><identifier>PMID: 20544323</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Aged ; Aged, 80 and over ; Bone Neoplasms - diagnostic imaging ; Bone Neoplasms - secondary ; Carbon Radioisotopes ; Choline ; Humans ; Imaging ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Staging ; Nuclear Medicine ; Original Article ; Positron-Emission Tomography ; Prostatic Neoplasms - diagnosis ; Prostatic Neoplasms - diagnostic imaging ; Prostatic Neoplasms - pathology ; Radiology ; Retrospective Studies ; Tomography, X-Ray Computed</subject><ispartof>Annals of nuclear medicine, 2010-07, Vol.24 (6), p.485-492</ispartof><rights>The Japanese Society of Nuclear Medicine 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c239x-14a970c1cd68f322f25bfb28574737461cda38bc60cb74f301907517116d99aa3</citedby><cites>FETCH-LOGICAL-c239x-14a970c1cd68f322f25bfb28574737461cda38bc60cb74f301907517116d99aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12149-010-0390-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12149-010-0390-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20544323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fuccio, Chiara</creatorcontrib><creatorcontrib>Castellucci, Paolo</creatorcontrib><creatorcontrib>Schiavina, Riccardo</creatorcontrib><creatorcontrib>Santi, Ivan</creatorcontrib><creatorcontrib>Allegri, Vincenzo</creatorcontrib><creatorcontrib>Pettinato, Vincenzina</creatorcontrib><creatorcontrib>Boschi, Stefano</creatorcontrib><creatorcontrib>Martorana, Giuseppe</creatorcontrib><creatorcontrib>Al-Nahhas, Adil</creatorcontrib><creatorcontrib>Rubello, Domenico</creatorcontrib><creatorcontrib>Fanti, Stefano</creatorcontrib><title>Role of 11C-choline PET/CT in the restaging of prostate cancer patients showing a single lesion on bone scintigraphy</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><addtitle>Ann Nucl Med</addtitle><description>Aim
To assess the utility of
11
C-choline PET/CT in the restaging of prostate cancer (PC) patients who showed a single finding on bone scintigraphy (BS) that was classified as equivocal or suspected for metastatic lesion.
Materials and methods
A total of 25 PC patients with biochemical failure (mean PSA value 11.1 ng/mL; median value 6.3 ng/mL; range 0.2–37.7 ng/mL) after primary treatment were included in this retrospective study. All of them showed a single lesion on BS reported as suspected for metastatic lesion or as equivocal finding. Patients underwent
11
C-choline PET/CT within 1–4 months from BS. Validation was established by follow-up for at least 6 months.
Results
On the basis of biopsy confirmation and/or 6-month follow-up, 22 of 25 patients were classified as positive for the presence of metastatic bone lesions: 13 with a single lesion and 9 with multiple lesions.
11
C-choline PET/CT was positive in 19/25 patients and, on a lesion basis, it showed 50 positive findings. BS results were confirmed in 8/25 (32%) patients.
11
C-choline PET/CT detected multiple sites of relapse in 11/25 (44%) patients: in 2/11, a single bone lesion associated with other extraosseous sites of relapse; in 6/11, multiple bone lesions; in 3/11, multiple bone lesions and other extraosseous localizations. Finally, 6/25 patients were negative on
11
C-choline PET/CT. In 3/6 patients, an osteoblastic lesion was seen on CT attenuation correction images (PET false negative; BS true positive), while in 3/6 patients only findings suggestive of the presence of degenerative disease were found (PET true negative; BS false positive). On a patient basis,
11
C-choline PET/CT showed a diagnostic sensitivity of 86% (19/22) and a specificity of 100% (19/19).
Conclusions
In our study,
11
C-choline PET/CT detected unknown lesions in 11/25 patients. Patients with a single equivocal finding on BS could have important additional information from
11
C-choline PET/CT study, especially in the detection of additional metastases, to choose an appropriate treatment.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bone Neoplasms - diagnostic imaging</subject><subject>Bone Neoplasms - secondary</subject><subject>Carbon Radioisotopes</subject><subject>Choline</subject><subject>Humans</subject><subject>Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Nuclear Medicine</subject><subject>Original Article</subject><subject>Positron-Emission Tomography</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Prostatic Neoplasms - diagnostic imaging</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Tomography, X-Ray Computed</subject><issn>0914-7187</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kcFqGzEQhkVJaZy0D9BLEbn0pGRGklerYzBpEgi0FPcstLLWVlhLjrQmzttXi9MWAoWBYZhvfs3oJ-QzwiUCqKuCHKVmgMBAaGCHd2SGbSNZI4U4ITPQKJnCVp2Ss1IeAXg7b_kHcsphLqXgYkbGn2nwNPUUccHcJg0hevrjZnm1WNIQ6bjxNPsy2nWI6wnb5VSr0VNno_OZ7uwYfBwLLZv0PDGWlpqq5uBLSJHW6FLVLC7EMayz3W1ePpL3vR2K__Saz8mvbzfLxR17-H57v7h-YI4LfWAorVbg0K2athec93ze9V29QUkllGxqw4q2cw24TsleAGpQc1SIzUpra8U5-XrUrVs_7esZZhuK88Ngo0_7YpQQuuVa8kpevCEf0z7HupxpJkFoG1EhPEKufkLJvje7HLY2vxgEMxlijoaYaoiZDDGHOvPlVXjfbf3q78QfByrAj0Cprbj2-d_L_1f9DQeClSA</recordid><startdate>201007</startdate><enddate>201007</enddate><creator>Fuccio, Chiara</creator><creator>Castellucci, Paolo</creator><creator>Schiavina, Riccardo</creator><creator>Santi, Ivan</creator><creator>Allegri, Vincenzo</creator><creator>Pettinato, Vincenzina</creator><creator>Boschi, Stefano</creator><creator>Martorana, Giuseppe</creator><creator>Al-Nahhas, Adil</creator><creator>Rubello, Domenico</creator><creator>Fanti, Stefano</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>201007</creationdate><title>Role of 11C-choline PET/CT in the restaging of prostate cancer patients showing a single lesion on bone scintigraphy</title><author>Fuccio, Chiara ; Castellucci, Paolo ; Schiavina, Riccardo ; Santi, Ivan ; Allegri, Vincenzo ; Pettinato, Vincenzina ; Boschi, Stefano ; Martorana, Giuseppe ; Al-Nahhas, Adil ; Rubello, Domenico ; Fanti, Stefano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c239x-14a970c1cd68f322f25bfb28574737461cda38bc60cb74f301907517116d99aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bone Neoplasms - diagnostic imaging</topic><topic>Bone Neoplasms - secondary</topic><topic>Carbon Radioisotopes</topic><topic>Choline</topic><topic>Humans</topic><topic>Imaging</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Nuclear Medicine</topic><topic>Original Article</topic><topic>Positron-Emission Tomography</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Prostatic Neoplasms - diagnostic imaging</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fuccio, Chiara</creatorcontrib><creatorcontrib>Castellucci, Paolo</creatorcontrib><creatorcontrib>Schiavina, Riccardo</creatorcontrib><creatorcontrib>Santi, Ivan</creatorcontrib><creatorcontrib>Allegri, Vincenzo</creatorcontrib><creatorcontrib>Pettinato, Vincenzina</creatorcontrib><creatorcontrib>Boschi, Stefano</creatorcontrib><creatorcontrib>Martorana, Giuseppe</creatorcontrib><creatorcontrib>Al-Nahhas, Adil</creatorcontrib><creatorcontrib>Rubello, Domenico</creatorcontrib><creatorcontrib>Fanti, Stefano</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fuccio, Chiara</au><au>Castellucci, Paolo</au><au>Schiavina, Riccardo</au><au>Santi, Ivan</au><au>Allegri, Vincenzo</au><au>Pettinato, Vincenzina</au><au>Boschi, Stefano</au><au>Martorana, Giuseppe</au><au>Al-Nahhas, Adil</au><au>Rubello, Domenico</au><au>Fanti, Stefano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of 11C-choline PET/CT in the restaging of prostate cancer patients showing a single lesion on bone scintigraphy</atitle><jtitle>Annals of nuclear medicine</jtitle><stitle>Ann Nucl Med</stitle><addtitle>Ann Nucl Med</addtitle><date>2010-07</date><risdate>2010</risdate><volume>24</volume><issue>6</issue><spage>485</spage><epage>492</epage><pages>485-492</pages><issn>0914-7187</issn><eissn>1864-6433</eissn><abstract>Aim
To assess the utility of
11
C-choline PET/CT in the restaging of prostate cancer (PC) patients who showed a single finding on bone scintigraphy (BS) that was classified as equivocal or suspected for metastatic lesion.
Materials and methods
A total of 25 PC patients with biochemical failure (mean PSA value 11.1 ng/mL; median value 6.3 ng/mL; range 0.2–37.7 ng/mL) after primary treatment were included in this retrospective study. All of them showed a single lesion on BS reported as suspected for metastatic lesion or as equivocal finding. Patients underwent
11
C-choline PET/CT within 1–4 months from BS. Validation was established by follow-up for at least 6 months.
Results
On the basis of biopsy confirmation and/or 6-month follow-up, 22 of 25 patients were classified as positive for the presence of metastatic bone lesions: 13 with a single lesion and 9 with multiple lesions.
11
C-choline PET/CT was positive in 19/25 patients and, on a lesion basis, it showed 50 positive findings. BS results were confirmed in 8/25 (32%) patients.
11
C-choline PET/CT detected multiple sites of relapse in 11/25 (44%) patients: in 2/11, a single bone lesion associated with other extraosseous sites of relapse; in 6/11, multiple bone lesions; in 3/11, multiple bone lesions and other extraosseous localizations. Finally, 6/25 patients were negative on
11
C-choline PET/CT. In 3/6 patients, an osteoblastic lesion was seen on CT attenuation correction images (PET false negative; BS true positive), while in 3/6 patients only findings suggestive of the presence of degenerative disease were found (PET true negative; BS false positive). On a patient basis,
11
C-choline PET/CT showed a diagnostic sensitivity of 86% (19/22) and a specificity of 100% (19/19).
Conclusions
In our study,
11
C-choline PET/CT detected unknown lesions in 11/25 patients. Patients with a single equivocal finding on BS could have important additional information from
11
C-choline PET/CT study, especially in the detection of additional metastases, to choose an appropriate treatment.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>20544323</pmid><doi>10.1007/s12149-010-0390-x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Annals of nuclear medicine, 2010-07, Vol.24 (6), p.485-492 |
| issn | 0914-7187 1864-6433 |
| language | eng |
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| source | MEDLINE; Springer Online Journals Complete |
| subjects | Aged Aged, 80 and over Bone Neoplasms - diagnostic imaging Bone Neoplasms - secondary Carbon Radioisotopes Choline Humans Imaging Male Medicine Medicine & Public Health Middle Aged Neoplasm Staging Nuclear Medicine Original Article Positron-Emission Tomography Prostatic Neoplasms - diagnosis Prostatic Neoplasms - diagnostic imaging Prostatic Neoplasms - pathology Radiology Retrospective Studies Tomography, X-Ray Computed |
| title | Role of 11C-choline PET/CT in the restaging of prostate cancer patients showing a single lesion on bone scintigraphy |
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