Acrosyringium Is the Main Site of the Vesicle/Pustule Formation in Palmoplantar Pustulosis
Pustulosis palmaris et plantaris or palmoplantar pustulosis (PPP) is a refractory pustular eruption on the palms and soles with unknown etiology. Numerous eccrine sweat pores exist on the palms and soles, suggesting the involvement of eccrine sweating in the pathogenesis of PPP. To the best of our k...
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| Veröffentlicht in: | Journal of investigative dermatology 2010-08, Vol.130 (8), p.2010-2016 |
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| creator | Murakami, Masamoto Ohtake, Takaaki Horibe, Yoshimune Ishida-Yamamoto, Akemi Morhenn, Vera B. Gallo, Richard L. Iizuka, Hajime |
| description | Pustulosis palmaris et plantaris or palmoplantar pustulosis (PPP) is a refractory pustular eruption on the palms and soles with unknown etiology. Numerous eccrine sweat pores exist on the palms and soles, suggesting the involvement of eccrine sweating in the pathogenesis of PPP. To the best of our knowledge, however, no definite abnormality in sweating has been documented in PPP. Accordingly, we analyzed the eccrine sweat duct involvement in the mechanism of vesicle formation in PPP. Dermatoscopy showed that PPP vesicles are located on the top of the ridges but not in the furrows. The sweat secretion in the lesional area was much lower than that in the nonlesional area, with or without pain stimulation to induce sweating. Immunostaining of horizontal sections of the lesions using antibodies against gross cystic disease fluid protein-15 (GCDFP-15) and epithelial membrane antigen (EMA) showed that these markers were localized in the cells lining the intraepidermal vesicles. Although the sweat antimicrobial peptides, dermcidin and human cathelicidin antimicrobial peptide 18 (hCAP-18)/LL-37, were detected in the fluid of the vesicles/pustules, neither dermcidin nor hCAP-18/LL-37 were overexpressed by neighboring keratinocytes. These findings suggest that the acrosyringium may be involved as the main site of the vesicle formation in the pathomechanism of PPP. |
| doi_str_mv | 10.1038/jid.2010.87 |
| format | Article |
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Numerous eccrine sweat pores exist on the palms and soles, suggesting the involvement of eccrine sweating in the pathogenesis of PPP. To the best of our knowledge, however, no definite abnormality in sweating has been documented in PPP. Accordingly, we analyzed the eccrine sweat duct involvement in the mechanism of vesicle formation in PPP. Dermatoscopy showed that PPP vesicles are located on the top of the ridges but not in the furrows. The sweat secretion in the lesional area was much lower than that in the nonlesional area, with or without pain stimulation to induce sweating. Immunostaining of horizontal sections of the lesions using antibodies against gross cystic disease fluid protein-15 (GCDFP-15) and epithelial membrane antigen (EMA) showed that these markers were localized in the cells lining the intraepidermal vesicles. Although the sweat antimicrobial peptides, dermcidin and human cathelicidin antimicrobial peptide 18 (hCAP-18)/LL-37, were detected in the fluid of the vesicles/pustules, neither dermcidin nor hCAP-18/LL-37 were overexpressed by neighboring keratinocytes. These findings suggest that the acrosyringium may be involved as the main site of the vesicle formation in the pathomechanism of PPP.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1038/jid.2010.87</identifier><identifier>PMID: 20393482</identifier><identifier>CODEN: JIDEAE</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antimicrobial Cationic Peptides - genetics ; Antimicrobial Cationic Peptides - metabolism ; Biological and medical sciences ; Biomarkers - metabolism ; Bullous diseases of the skin ; Carrier Proteins - metabolism ; Dermatology ; Epidermis - metabolism ; Epidermis - pathology ; Female ; Glycoproteins - metabolism ; Humans ; Keratinocytes - metabolism ; Keratinocytes - pathology ; Male ; Medical sciences ; Membrane Transport Proteins ; Middle Aged ; Mucin-1 - metabolism ; Nerve Tissue Proteins - metabolism ; Peptides ; Psoriasis - etiology ; Psoriasis - metabolism ; Psoriasis - pathology ; RNA, Messenger - metabolism ; Sweat Glands - metabolism ; Sweat Glands - pathology ; Sweating - physiology ; Up-Regulation - physiology</subject><ispartof>Journal of investigative dermatology, 2010-08, Vol.130 (8), p.2010-2016</ispartof><rights>2010 The Society for Investigative Dermatology, Inc</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Aug 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-848273ca6872d607400d13d589cae592eeb18e2bd40d178c189a2b458816dbe73</citedby><cites>FETCH-LOGICAL-c562t-848273ca6872d607400d13d589cae592eeb18e2bd40d178c189a2b458816dbe73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/609951585?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,64366,64368,64370,72220</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23054702$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20393482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murakami, Masamoto</creatorcontrib><creatorcontrib>Ohtake, Takaaki</creatorcontrib><creatorcontrib>Horibe, Yoshimune</creatorcontrib><creatorcontrib>Ishida-Yamamoto, Akemi</creatorcontrib><creatorcontrib>Morhenn, Vera B.</creatorcontrib><creatorcontrib>Gallo, Richard L.</creatorcontrib><creatorcontrib>Iizuka, Hajime</creatorcontrib><title>Acrosyringium Is the Main Site of the Vesicle/Pustule Formation in Palmoplantar Pustulosis</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>Pustulosis palmaris et plantaris or palmoplantar pustulosis (PPP) is a refractory pustular eruption on the palms and soles with unknown etiology. Numerous eccrine sweat pores exist on the palms and soles, suggesting the involvement of eccrine sweating in the pathogenesis of PPP. To the best of our knowledge, however, no definite abnormality in sweating has been documented in PPP. Accordingly, we analyzed the eccrine sweat duct involvement in the mechanism of vesicle formation in PPP. Dermatoscopy showed that PPP vesicles are located on the top of the ridges but not in the furrows. The sweat secretion in the lesional area was much lower than that in the nonlesional area, with or without pain stimulation to induce sweating. Immunostaining of horizontal sections of the lesions using antibodies against gross cystic disease fluid protein-15 (GCDFP-15) and epithelial membrane antigen (EMA) showed that these markers were localized in the cells lining the intraepidermal vesicles. Although the sweat antimicrobial peptides, dermcidin and human cathelicidin antimicrobial peptide 18 (hCAP-18)/LL-37, were detected in the fluid of the vesicles/pustules, neither dermcidin nor hCAP-18/LL-37 were overexpressed by neighboring keratinocytes. These findings suggest that the acrosyringium may be involved as the main site of the vesicle formation in the pathomechanism of PPP.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antimicrobial Cationic Peptides - genetics</subject><subject>Antimicrobial Cationic Peptides - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - metabolism</subject><subject>Bullous diseases of the skin</subject><subject>Carrier Proteins - metabolism</subject><subject>Dermatology</subject><subject>Epidermis - metabolism</subject><subject>Epidermis - pathology</subject><subject>Female</subject><subject>Glycoproteins - metabolism</subject><subject>Humans</subject><subject>Keratinocytes - metabolism</subject><subject>Keratinocytes - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Transport Proteins</subject><subject>Middle Aged</subject><subject>Mucin-1 - metabolism</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Peptides</subject><subject>Psoriasis - etiology</subject><subject>Psoriasis - metabolism</subject><subject>Psoriasis - pathology</subject><subject>RNA, Messenger - metabolism</subject><subject>Sweat Glands - metabolism</subject><subject>Sweat Glands - pathology</subject><subject>Sweating - physiology</subject><subject>Up-Regulation - physiology</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpt0Etr3DAUBWBRUprJtKvsGxMoWRQneliWvBxCJw2kNNAHJRshS3daDbY1keRC_n3keJpC6UpIfNx7dBA6JvicYCYvts6eU5xvUrxAC8IpK4moxAFaYExpSTH9cYiOYtxiTOqKy1fokGLWsErSBbpbmeDjQ3DDTzf2xXUs0i8oPmk3FF9cgsJvnh6-Q3Smg4vbMaaxg2LtQ6-T80OR4a3uer_r9JB0KGbho4uv0cuN7iK82Z9L9G394evlx_Lm89X15eqmNLymqZQ5h2BG11JQW2NRYWwJs1w2RgNvKEBLJNDWVvldSENko2mb_yFJbVsQbInO5rm74O9HiEn1LhrociDwY1SCsUZSwlmWp__IrR_DkMOpGjcNJ1zyjN7PaComBtioXXC9Dg-KYDUVrnLhaipcyWn52_3Ise3BPts_DWfwbg90NLrbBD0YF_86hnkl8OROZjfoNAZ4BnnZtOtpFZ8F5DJ_OwgqGgeDAesCmKSsd_-N-Ai-daRs</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>Murakami, Masamoto</creator><creator>Ohtake, Takaaki</creator><creator>Horibe, Yoshimune</creator><creator>Ishida-Yamamoto, Akemi</creator><creator>Morhenn, Vera B.</creator><creator>Gallo, Richard L.</creator><creator>Iizuka, Hajime</creator><general>Elsevier Inc</general><general>Nature Publishing Group</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20100801</creationdate><title>Acrosyringium Is the Main Site of the Vesicle/Pustule Formation in Palmoplantar Pustulosis</title><author>Murakami, Masamoto ; 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Numerous eccrine sweat pores exist on the palms and soles, suggesting the involvement of eccrine sweating in the pathogenesis of PPP. To the best of our knowledge, however, no definite abnormality in sweating has been documented in PPP. Accordingly, we analyzed the eccrine sweat duct involvement in the mechanism of vesicle formation in PPP. Dermatoscopy showed that PPP vesicles are located on the top of the ridges but not in the furrows. The sweat secretion in the lesional area was much lower than that in the nonlesional area, with or without pain stimulation to induce sweating. Immunostaining of horizontal sections of the lesions using antibodies against gross cystic disease fluid protein-15 (GCDFP-15) and epithelial membrane antigen (EMA) showed that these markers were localized in the cells lining the intraepidermal vesicles. Although the sweat antimicrobial peptides, dermcidin and human cathelicidin antimicrobial peptide 18 (hCAP-18)/LL-37, were detected in the fluid of the vesicles/pustules, neither dermcidin nor hCAP-18/LL-37 were overexpressed by neighboring keratinocytes. These findings suggest that the acrosyringium may be involved as the main site of the vesicle formation in the pathomechanism of PPP.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>20393482</pmid><doi>10.1038/jid.2010.87</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Antimicrobial Cationic Peptides - genetics Antimicrobial Cationic Peptides - metabolism Biological and medical sciences Biomarkers - metabolism Bullous diseases of the skin Carrier Proteins - metabolism Dermatology Epidermis - metabolism Epidermis - pathology Female Glycoproteins - metabolism Humans Keratinocytes - metabolism Keratinocytes - pathology Male Medical sciences Membrane Transport Proteins Middle Aged Mucin-1 - metabolism Nerve Tissue Proteins - metabolism Peptides Psoriasis - etiology Psoriasis - metabolism Psoriasis - pathology RNA, Messenger - metabolism Sweat Glands - metabolism Sweat Glands - pathology Sweating - physiology Up-Regulation - physiology |
| title | Acrosyringium Is the Main Site of the Vesicle/Pustule Formation in Palmoplantar Pustulosis |
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