Antagonism and synergism in Gardnerella vaginalis strains isolated from women with bacterial vaginosis
Antagonistic and synergistic substances are important for interactions between micro-organisms associated with human body surfaces, either in healthy or in diseased conditions. In the present study, such compounds produced by Gardnerella vaginalis strains isolated from women with bacterial vaginosis...
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| Veröffentlicht in: | Journal of medical microbiology 2010-08, Vol.59 (8), p.891-897 |
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| creator | TEIXEIRA, G. S SOARES-BRANDAO, K. L. K BRANCO, K. M. G. R SAMPAIO, J. L. M NARDI, R. M. D MENDONCA, M ALMEIDA, R. B FARIAS, L. M CARVALHO, M. A. R NICOLI, J. R |
| description | Antagonistic and synergistic substances are important for interactions between micro-organisms associated with human body surfaces, either in healthy or in diseased conditions. In the present study, such compounds produced by Gardnerella vaginalis strains isolated from women with bacterial vaginosis (BV) were detected in vitro and the antagonistic ones were partially characterized. Among 11 G. vaginalis strains tested, all showed antagonistic activity against at least one of the 22 indicator bacteria assayed. Interestingly, for some of these strains, antagonism reverted to synergism, favouring one of the indicator strains (Peptostreptococcus anaerobius) when the growth medium was changed. Partial characterization of antagonistic substances suggested a bacteriocin-like chemical nature. Depending on growth conditions, G. vaginalis isolated from women with BV produced antagonistic or synergistic compounds for other bacterial components of the vaginal ecosystem. This is the first report to our knowledge of the production of antagonistic and/or synergistic substances by G. vaginalis. This ability may be a pivotal factor in understanding BV and the ecological role of this bacterium in the vaginal environment. |
| doi_str_mv | 10.1099/jmm.0.019794-0 |
| format | Article |
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S ; SOARES-BRANDAO, K. L. K ; BRANCO, K. M. G. R ; SAMPAIO, J. L. M ; NARDI, R. M. D ; MENDONCA, M ; ALMEIDA, R. B ; FARIAS, L. M ; CARVALHO, M. A. R ; NICOLI, J. R</creator><creatorcontrib>TEIXEIRA, G. S ; SOARES-BRANDAO, K. L. K ; BRANCO, K. M. G. R ; SAMPAIO, J. L. M ; NARDI, R. M. D ; MENDONCA, M ; ALMEIDA, R. B ; FARIAS, L. M ; CARVALHO, M. A. R ; NICOLI, J. R</creatorcontrib><description>Antagonistic and synergistic substances are important for interactions between micro-organisms associated with human body surfaces, either in healthy or in diseased conditions. In the present study, such compounds produced by Gardnerella vaginalis strains isolated from women with bacterial vaginosis (BV) were detected in vitro and the antagonistic ones were partially characterized. Among 11 G. vaginalis strains tested, all showed antagonistic activity against at least one of the 22 indicator bacteria assayed. Interestingly, for some of these strains, antagonism reverted to synergism, favouring one of the indicator strains (Peptostreptococcus anaerobius) when the growth medium was changed. Partial characterization of antagonistic substances suggested a bacteriocin-like chemical nature. Depending on growth conditions, G. vaginalis isolated from women with BV produced antagonistic or synergistic compounds for other bacterial components of the vaginal ecosystem. This is the first report to our knowledge of the production of antagonistic and/or synergistic substances by G. vaginalis. 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S</creatorcontrib><creatorcontrib>SOARES-BRANDAO, K. L. K</creatorcontrib><creatorcontrib>BRANCO, K. M. G. R</creatorcontrib><creatorcontrib>SAMPAIO, J. L. M</creatorcontrib><creatorcontrib>NARDI, R. M. D</creatorcontrib><creatorcontrib>MENDONCA, M</creatorcontrib><creatorcontrib>ALMEIDA, R. B</creatorcontrib><creatorcontrib>FARIAS, L. M</creatorcontrib><creatorcontrib>CARVALHO, M. A. R</creatorcontrib><creatorcontrib>NICOLI, J. R</creatorcontrib><title>Antagonism and synergism in Gardnerella vaginalis strains isolated from women with bacterial vaginosis</title><title>Journal of medical microbiology</title><addtitle>J Med Microbiol</addtitle><description>Antagonistic and synergistic substances are important for interactions between micro-organisms associated with human body surfaces, either in healthy or in diseased conditions. In the present study, such compounds produced by Gardnerella vaginalis strains isolated from women with bacterial vaginosis (BV) were detected in vitro and the antagonistic ones were partially characterized. Among 11 G. vaginalis strains tested, all showed antagonistic activity against at least one of the 22 indicator bacteria assayed. Interestingly, for some of these strains, antagonism reverted to synergism, favouring one of the indicator strains (Peptostreptococcus anaerobius) when the growth medium was changed. Partial characterization of antagonistic substances suggested a bacteriocin-like chemical nature. Depending on growth conditions, G. vaginalis isolated from women with BV produced antagonistic or synergistic compounds for other bacterial components of the vaginal ecosystem. This is the first report to our knowledge of the production of antagonistic and/or synergistic substances by G. vaginalis. This ability may be a pivotal factor in understanding BV and the ecological role of this bacterium in the vaginal environment.</description><subject>Anti-Bacterial Agents - biosynthesis</subject><subject>Antibiosis</subject><subject>Bacteria - drug effects</subject><subject>Bacteriocins - biosynthesis</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Culture Media - chemistry</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gardnerella vaginalis - isolation & purification</subject><subject>Gardnerella vaginalis - pathogenicity</subject><subject>Gardnerella vaginalis - physiology</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Vaginosis, Bacterial - microbiology</subject><subject>Virulence</subject><issn>0022-2615</issn><issn>1473-5644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFP3DAQha2Kqmxprz0iX1BP2Y5jx2sfEQKKhNRLe7YmyXhrlDjgyYL4981ql3IaPel7T5pPiG8K1gq8__EwjmtYg_Ibbyr4IFbKbHTVWGNOxAqgrqvaquZUfGZ-AFAbrf0ncVqDsdYZtRLxMs-4nXLiUWLuJb9mKtt9SlneYumXSMOA8hm3KeOQWPJcMGWWiacBZ-plLNMoX6aRsnxJ81_ZYjdTSTgcShMn_iI-RhyYvh7vmfhzc_376md1_-v27uryvuq0NXPlI_QutqhabylaaIxtUJuGbE8RHFGjG-d07dBZbKzf9JGs1uSdqSPYVp-J74fdxzI97YjnMCbu9g9kmnYc9v875ZxdyPWB7MrEXCiGx5JGLK9BQdirDYvaAOGgNsBSOD9O79qR-v_4m8sFuDgCyB0OsWDuEr9zGqz1UOt_YTSDgw</recordid><startdate>20100801</startdate><enddate>20100801</enddate><creator>TEIXEIRA, G. 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| ispartof | Journal of medical microbiology, 2010-08, Vol.59 (8), p.891-897 |
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| subjects | Anti-Bacterial Agents - biosynthesis Antibiosis Bacteria - drug effects Bacteriocins - biosynthesis Bacteriology Biological and medical sciences Culture Media - chemistry Female Fundamental and applied biological sciences. Psychology Gardnerella vaginalis - isolation & purification Gardnerella vaginalis - pathogenicity Gardnerella vaginalis - physiology Humans Infectious diseases Medical sciences Microbiology Miscellaneous Vaginosis, Bacterial - microbiology Virulence |
| title | Antagonism and synergism in Gardnerella vaginalis strains isolated from women with bacterial vaginosis |
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