Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma
Abstract Purpose The study aimed to analyze the expression of bone morphogenetic protein-2/4 (BMP-2/4) and its receptor BMPR-IA (BMP receptor type IA) in metastatic and nonmetastatic oral squamous cell carcinoma (OSCC) and its implications for disease prognosis. Materials and methods The experimenta...
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| Veröffentlicht in: | American journal of otolaryngology 2010-07, Vol.31 (4), p.266-271 |
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| creator | Soares, Andréa Ferreira, DDs, MSc, PhD Xavier, Ruth Lopes de Freitas, DDs, MSc da Costa Miguel, Márcia Cristina, DDs, MSc, PhD de Souza, Lélia Batista, DDs, MSc, PhD Pinto, Leão Pereira, DDs, MSc, PhD |
| description | Abstract Purpose The study aimed to analyze the expression of bone morphogenetic protein-2/4 (BMP-2/4) and its receptor BMPR-IA (BMP receptor type IA) in metastatic and nonmetastatic oral squamous cell carcinoma (OSCC) and its implications for disease prognosis. Materials and methods The experimental group included 16 cases of OSCC without metastasis and 7 cases of OSCC with metastasis. The presence or absence of nodal metastasis was used as a parameter for the evaluation of disease prognosis. Ten cases of oral fibroepithelial hyperplasia were selected as the control group. The expression of BMP-2/4 and BMPR-IA was analyzed by immunohistochemistry. Results In the experimental group with metastasis, strong expression of BMP-2/4 was observed in most cases (71.4%), whereas BMPR-IA exhibited weak expression (85.7%). In the experimental group without metastasis, there was strong expression of BMP-2/4 (62.5%) and BMPR-IA (100%). A significant association was observed between the prognosis of OSCC and the intensity of BMP-2/4 staining ( P = .002). Weak immunoreactivity to BMP-2/4 and BMPR-IA was observed in all control specimens. Conclusions The results suggest that strong expression of BMP-2/4, associated with low expression of BMPR-IA, observed in metastatic OSCC has a prognostic value, with the loss of responsiveness to BMPs through the loss of expression of their receptors being indicative of the development of metastasis. |
| doi_str_mv | 10.1016/j.amjoto.2009.03.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733980214</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0196070909000520</els_id><sourcerecordid>733980214</sourcerecordid><originalsourceid>FETCH-LOGICAL-c520t-6fa78f9ef111ae0d2d5c5e5008f1184e5f1f064381c2fae8c11f8a6098be834c3</originalsourceid><addsrcrecordid>eNqFkt-K1DAUxoMo7rj6BiIBEa_aPUnaTnoj7C7-WVjwQgXvQiY91dQ26SapOC_i85oyoysLIrkIJL_v5Dv5DiFPGZQMWHM2lHoafPIlB2hLECUAv0c2rBa8kEx-vk82wNqmgC20J-RRjAMAiErUD8lJlrB622w35OeFd0gnH-av_gs6TNbQOfiE1hX8rKLadXT3T4QGNDgnH2jaz0ivzin-mAPGaL2j-XrCpGPSq2It5Lz768QHPdJ4s-jJL5EaHEdqdDDW-Uk_Jg96PUZ8ctxPyac3rz9eviuu37-9ujy_LkzNIRVNr7eyb7FnjGmEjne1qbEGkPlEVlj3rIemEpIZ3muUhrFe6gZauUMpKiNOyctD3dzQzYIxqcnG1Yp2mF2prRCtBM6qTD6_Qw5-CS6bUwwEE41oOWSqOlAm-BgD9moOdtJhnyG1xqYGdYhNrbEpECrHlmXPjsWX3YTdH9HvnDLw4gjoaPTYB-2MjbecyFEDbzL36sBh_rTvFoOKxqIz2NkcVVKdt_9zcreAGa2z-c1vuMd427OKXIH6sI7YOmF5AeRMxC-YKM8H</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1031363920</pqid></control><display><type>article</type><title>Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Soares, Andréa Ferreira, DDs, MSc, PhD ; Xavier, Ruth Lopes de Freitas, DDs, MSc ; da Costa Miguel, Márcia Cristina, DDs, MSc, PhD ; de Souza, Lélia Batista, DDs, MSc, PhD ; Pinto, Leão Pereira, DDs, MSc, PhD</creator><creatorcontrib>Soares, Andréa Ferreira, DDs, MSc, PhD ; Xavier, Ruth Lopes de Freitas, DDs, MSc ; da Costa Miguel, Márcia Cristina, DDs, MSc, PhD ; de Souza, Lélia Batista, DDs, MSc, PhD ; Pinto, Leão Pereira, DDs, MSc, PhD</creatorcontrib><description>Abstract Purpose The study aimed to analyze the expression of bone morphogenetic protein-2/4 (BMP-2/4) and its receptor BMPR-IA (BMP receptor type IA) in metastatic and nonmetastatic oral squamous cell carcinoma (OSCC) and its implications for disease prognosis. Materials and methods The experimental group included 16 cases of OSCC without metastasis and 7 cases of OSCC with metastasis. The presence or absence of nodal metastasis was used as a parameter for the evaluation of disease prognosis. Ten cases of oral fibroepithelial hyperplasia were selected as the control group. The expression of BMP-2/4 and BMPR-IA was analyzed by immunohistochemistry. Results In the experimental group with metastasis, strong expression of BMP-2/4 was observed in most cases (71.4%), whereas BMPR-IA exhibited weak expression (85.7%). In the experimental group without metastasis, there was strong expression of BMP-2/4 (62.5%) and BMPR-IA (100%). A significant association was observed between the prognosis of OSCC and the intensity of BMP-2/4 staining ( P = .002). Weak immunoreactivity to BMP-2/4 and BMPR-IA was observed in all control specimens. Conclusions The results suggest that strong expression of BMP-2/4, associated with low expression of BMPR-IA, observed in metastatic OSCC has a prognostic value, with the loss of responsiveness to BMPs through the loss of expression of their receptors being indicative of the development of metastasis.</description><identifier>ISSN: 0196-0709</identifier><identifier>EISSN: 1532-818X</identifier><identifier>DOI: 10.1016/j.amjoto.2009.03.002</identifier><identifier>PMID: 20015767</identifier><identifier>CODEN: AJOTDP</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Biomarkers, Tumor - biosynthesis ; Bone Morphogenetic Protein 4 - biosynthesis ; Bone Morphogenetic Protein Receptors, Type I - biosynthesis ; Cancer ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - secondary ; Disease Progression ; Humans ; Immunohistochemistry ; Medical sciences ; Mouth Neoplasms - metabolism ; Mouth Neoplasms - pathology ; Neoplasm Metastasis ; Otolaryngology ; Otorhinolaryngology. Stomatology ; Pathology ; Prognosis ; Proteins ; Retrospective Studies ; Studies ; Surgery ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>American journal of otolaryngology, 2010-07, Vol.31 (4), p.266-271</ispartof><rights>2010</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010. Published by Elsevier Inc.</rights><rights>Copyright Elsevier Limited 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-6fa78f9ef111ae0d2d5c5e5008f1184e5f1f064381c2fae8c11f8a6098be834c3</citedby><cites>FETCH-LOGICAL-c520t-6fa78f9ef111ae0d2d5c5e5008f1184e5f1f064381c2fae8c11f8a6098be834c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.amjoto.2009.03.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23019026$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20015767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soares, Andréa Ferreira, DDs, MSc, PhD</creatorcontrib><creatorcontrib>Xavier, Ruth Lopes de Freitas, DDs, MSc</creatorcontrib><creatorcontrib>da Costa Miguel, Márcia Cristina, DDs, MSc, PhD</creatorcontrib><creatorcontrib>de Souza, Lélia Batista, DDs, MSc, PhD</creatorcontrib><creatorcontrib>Pinto, Leão Pereira, DDs, MSc, PhD</creatorcontrib><title>Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma</title><title>American journal of otolaryngology</title><addtitle>Am J Otolaryngol</addtitle><description>Abstract Purpose The study aimed to analyze the expression of bone morphogenetic protein-2/4 (BMP-2/4) and its receptor BMPR-IA (BMP receptor type IA) in metastatic and nonmetastatic oral squamous cell carcinoma (OSCC) and its implications for disease prognosis. Materials and methods The experimental group included 16 cases of OSCC without metastasis and 7 cases of OSCC with metastasis. The presence or absence of nodal metastasis was used as a parameter for the evaluation of disease prognosis. Ten cases of oral fibroepithelial hyperplasia were selected as the control group. The expression of BMP-2/4 and BMPR-IA was analyzed by immunohistochemistry. Results In the experimental group with metastasis, strong expression of BMP-2/4 was observed in most cases (71.4%), whereas BMPR-IA exhibited weak expression (85.7%). In the experimental group without metastasis, there was strong expression of BMP-2/4 (62.5%) and BMPR-IA (100%). A significant association was observed between the prognosis of OSCC and the intensity of BMP-2/4 staining ( P = .002). Weak immunoreactivity to BMP-2/4 and BMPR-IA was observed in all control specimens. Conclusions The results suggest that strong expression of BMP-2/4, associated with low expression of BMPR-IA, observed in metastatic OSCC has a prognostic value, with the loss of responsiveness to BMPs through the loss of expression of their receptors being indicative of the development of metastasis.</description><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - biosynthesis</subject><subject>Bone Morphogenetic Protein 4 - biosynthesis</subject><subject>Bone Morphogenetic Protein Receptors, Type I - biosynthesis</subject><subject>Cancer</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Disease Progression</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Medical sciences</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Mouth Neoplasms - pathology</subject><subject>Neoplasm Metastasis</subject><subject>Otolaryngology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Pathology</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Retrospective Studies</subject><subject>Studies</subject><subject>Surgery</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0196-0709</issn><issn>1532-818X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt-K1DAUxoMo7rj6BiIBEa_aPUnaTnoj7C7-WVjwQgXvQiY91dQ26SapOC_i85oyoysLIrkIJL_v5Dv5DiFPGZQMWHM2lHoafPIlB2hLECUAv0c2rBa8kEx-vk82wNqmgC20J-RRjAMAiErUD8lJlrB622w35OeFd0gnH-av_gs6TNbQOfiE1hX8rKLadXT3T4QGNDgnH2jaz0ivzin-mAPGaL2j-XrCpGPSq2It5Lz768QHPdJ4s-jJL5EaHEdqdDDW-Uk_Jg96PUZ8ctxPyac3rz9eviuu37-9ujy_LkzNIRVNr7eyb7FnjGmEjne1qbEGkPlEVlj3rIemEpIZ3muUhrFe6gZauUMpKiNOyctD3dzQzYIxqcnG1Yp2mF2prRCtBM6qTD6_Qw5-CS6bUwwEE41oOWSqOlAm-BgD9moOdtJhnyG1xqYGdYhNrbEpECrHlmXPjsWX3YTdH9HvnDLw4gjoaPTYB-2MjbecyFEDbzL36sBh_rTvFoOKxqIz2NkcVVKdt_9zcreAGa2z-c1vuMd427OKXIH6sI7YOmF5AeRMxC-YKM8H</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Soares, Andréa Ferreira, DDs, MSc, PhD</creator><creator>Xavier, Ruth Lopes de Freitas, DDs, MSc</creator><creator>da Costa Miguel, Márcia Cristina, DDs, MSc, PhD</creator><creator>de Souza, Lélia Batista, DDs, MSc, PhD</creator><creator>Pinto, Leão Pereira, DDs, MSc, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20100701</creationdate><title>Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma</title><author>Soares, Andréa Ferreira, DDs, MSc, PhD ; Xavier, Ruth Lopes de Freitas, DDs, MSc ; da Costa Miguel, Márcia Cristina, DDs, MSc, PhD ; de Souza, Lélia Batista, DDs, MSc, PhD ; Pinto, Leão Pereira, DDs, MSc, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-6fa78f9ef111ae0d2d5c5e5008f1184e5f1f064381c2fae8c11f8a6098be834c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - biosynthesis</topic><topic>Bone Morphogenetic Protein 4 - biosynthesis</topic><topic>Bone Morphogenetic Protein Receptors, Type I - biosynthesis</topic><topic>Cancer</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Disease Progression</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Medical sciences</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Mouth Neoplasms - pathology</topic><topic>Neoplasm Metastasis</topic><topic>Otolaryngology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Pathology</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Retrospective Studies</topic><topic>Studies</topic><topic>Surgery</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Soares, Andréa Ferreira, DDs, MSc, PhD</creatorcontrib><creatorcontrib>Xavier, Ruth Lopes de Freitas, DDs, MSc</creatorcontrib><creatorcontrib>da Costa Miguel, Márcia Cristina, DDs, MSc, PhD</creatorcontrib><creatorcontrib>de Souza, Lélia Batista, DDs, MSc, PhD</creatorcontrib><creatorcontrib>Pinto, Leão Pereira, DDs, MSc, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of otolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Soares, Andréa Ferreira, DDs, MSc, PhD</au><au>Xavier, Ruth Lopes de Freitas, DDs, MSc</au><au>da Costa Miguel, Márcia Cristina, DDs, MSc, PhD</au><au>de Souza, Lélia Batista, DDs, MSc, PhD</au><au>Pinto, Leão Pereira, DDs, MSc, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma</atitle><jtitle>American journal of otolaryngology</jtitle><addtitle>Am J Otolaryngol</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>31</volume><issue>4</issue><spage>266</spage><epage>271</epage><pages>266-271</pages><issn>0196-0709</issn><eissn>1532-818X</eissn><coden>AJOTDP</coden><abstract>Abstract Purpose The study aimed to analyze the expression of bone morphogenetic protein-2/4 (BMP-2/4) and its receptor BMPR-IA (BMP receptor type IA) in metastatic and nonmetastatic oral squamous cell carcinoma (OSCC) and its implications for disease prognosis. Materials and methods The experimental group included 16 cases of OSCC without metastasis and 7 cases of OSCC with metastasis. The presence or absence of nodal metastasis was used as a parameter for the evaluation of disease prognosis. Ten cases of oral fibroepithelial hyperplasia were selected as the control group. The expression of BMP-2/4 and BMPR-IA was analyzed by immunohistochemistry. Results In the experimental group with metastasis, strong expression of BMP-2/4 was observed in most cases (71.4%), whereas BMPR-IA exhibited weak expression (85.7%). In the experimental group without metastasis, there was strong expression of BMP-2/4 (62.5%) and BMPR-IA (100%). A significant association was observed between the prognosis of OSCC and the intensity of BMP-2/4 staining ( P = .002). Weak immunoreactivity to BMP-2/4 and BMPR-IA was observed in all control specimens. Conclusions The results suggest that strong expression of BMP-2/4, associated with low expression of BMPR-IA, observed in metastatic OSCC has a prognostic value, with the loss of responsiveness to BMPs through the loss of expression of their receptors being indicative of the development of metastasis.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>20015767</pmid><doi>10.1016/j.amjoto.2009.03.002</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Biomarkers, Tumor - biosynthesis Bone Morphogenetic Protein 4 - biosynthesis Bone Morphogenetic Protein Receptors, Type I - biosynthesis Cancer Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - secondary Disease Progression Humans Immunohistochemistry Medical sciences Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Neoplasm Metastasis Otolaryngology Otorhinolaryngology. Stomatology Pathology Prognosis Proteins Retrospective Studies Studies Surgery Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Bone morphogenetic protein-2/4 and bone morphogenetic protein receptor type IA expression in metastatic and nonmetastatic oral squamous cell carcinoma |
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