Effect of Perioperative Administration of a Drug Regimen on the Primary Function of Human Renal Allografts
Abstract Delayed graft function (DGF) has one of the greatest effects on short- and long-term outcomes of cadaveric renal allografts. Ischemia reperfusion injury in the context of cold ischemia time and acute calcineurin inhibitor (CNI) nephrotoxicity is a major factor predisposing to DGF. A drug re...
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| Veröffentlicht in: | Transplantation proceedings 2010-06, Vol.42 (5), p.1523-1525 |
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| creator | Brauer, R.B Marx, T Ulm, K Stangl, M.J |
| description | Abstract Delayed graft function (DGF) has one of the greatest effects on short- and long-term outcomes of cadaveric renal allografts. Ischemia reperfusion injury in the context of cold ischemia time and acute calcineurin inhibitor (CNI) nephrotoxicity is a major factor predisposing to DGF. A drug regimen consisting of prostaglandin E1 (PGE1 ) furosemide and dopamine has been used to reduce DGF after kidney transplantation. Prostaglandin E1 has multiple anti-ischemic and tissue-protective abilities, furosemide improves diuresis, and dopamine augments renal blood flow and urinary volume. To evaluate a potential positive effect of this drug regimen on the primary function of cadaveric renal allografts, we performed a retrospective single-center study that compared 100 patients who received this regimen with a control group. The results showed no significant improvement in renal function. In contrast, plasma levels of creatinine and urea were increased in the drug regimen group. Thus, the effectiveness of PGE1 in combination with high-dose furosemide and dopamine in diminishing DGF was not demonstrated in this trial. |
| doi_str_mv | 10.1016/j.transproceed.2010.01.057 |
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Ischemia reperfusion injury in the context of cold ischemia time and acute calcineurin inhibitor (CNI) nephrotoxicity is a major factor predisposing to DGF. A drug regimen consisting of prostaglandin E1 (PGE1 ) furosemide and dopamine has been used to reduce DGF after kidney transplantation. Prostaglandin E1 has multiple anti-ischemic and tissue-protective abilities, furosemide improves diuresis, and dopamine augments renal blood flow and urinary volume. To evaluate a potential positive effect of this drug regimen on the primary function of cadaveric renal allografts, we performed a retrospective single-center study that compared 100 patients who received this regimen with a control group. The results showed no significant improvement in renal function. In contrast, plasma levels of creatinine and urea were increased in the drug regimen group. Thus, the effectiveness of PGE1 in combination with high-dose furosemide and dopamine in diminishing DGF was not demonstrated in this trial.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2010.01.057</identifier><identifier>PMID: 20620467</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject><![CDATA[Adult ; Alprostadil - administration & dosage ; Alprostadil - therapeutic use ; Biological and medical sciences ; Cadaver ; Diuretics - administration & dosage ; Diuretics - therapeutic use ; Dopamine - administration & dosage ; Dopamine - therapeutic use ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Furosemide - administration & dosage ; Furosemide - therapeutic use ; Graft Rejection - epidemiology ; Graft Rejection - prevention & control ; Humans ; Intraoperative Period ; Kidney Transplantation - physiology ; Male ; Medical sciences ; Middle Aged ; Renal Dialysis - statistics & numerical data ; Retrospective Studies ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. 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Ischemia reperfusion injury in the context of cold ischemia time and acute calcineurin inhibitor (CNI) nephrotoxicity is a major factor predisposing to DGF. A drug regimen consisting of prostaglandin E1 (PGE1 ) furosemide and dopamine has been used to reduce DGF after kidney transplantation. Prostaglandin E1 has multiple anti-ischemic and tissue-protective abilities, furosemide improves diuresis, and dopamine augments renal blood flow and urinary volume. To evaluate a potential positive effect of this drug regimen on the primary function of cadaveric renal allografts, we performed a retrospective single-center study that compared 100 patients who received this regimen with a control group. The results showed no significant improvement in renal function. In contrast, plasma levels of creatinine and urea were increased in the drug regimen group. Thus, the effectiveness of PGE1 in combination with high-dose furosemide and dopamine in diminishing DGF was not demonstrated in this trial.</description><subject>Adult</subject><subject>Alprostadil - administration & dosage</subject><subject>Alprostadil - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cadaver</subject><subject>Diuretics - administration & dosage</subject><subject>Diuretics - therapeutic use</subject><subject>Dopamine - administration & dosage</subject><subject>Dopamine - therapeutic use</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Furosemide - administration & dosage</subject><subject>Furosemide - therapeutic use</subject><subject>Graft Rejection - epidemiology</subject><subject>Graft Rejection - prevention & control</subject><subject>Humans</subject><subject>Intraoperative Period</subject><subject>Kidney Transplantation - physiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Renal Dialysis - statistics & numerical data</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue Donors</subject><subject>Tissue, organ and graft immunology</subject><subject>Transplantation, Homologous</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkt2L1DAQwIMo3nr6L0gR5J66Tj6atD4Iy314woGH3ntIs5M1tW3WpD24_96U3UXxyaeQzG8myW-GkHcU1hSo_NCtp2jGtI_BIm7XDHIA6Boq9YysaK14ySTjz8kKQNCSclGdkVcpdZD3TPCX5IyBZCCkWpHu2jm0UxFccY_Rhz1GM_lHLDbbwY8-Tcs2jEvcFFdx3hXfcOcHzCdjMf3A4j76wcSn4mYe7Ym8nQczZnA0fbHp-7CLxk3pNXnhTJ_wzXE9Jw831w-Xt-Xd189fLjd3pRVSTCWrJVbGSVmJtrWmrmupJFIAVSkukFmHKKCBuqmtRdnWIAWvoOGWVY62_JxcHMpmP79mTJMefLLY92bEMCetOG-UYkpl8uOBtDGkFNHp_eEzmoJeTOtO_21aL6Y1UJ1N5-S3x2vmdsixU-pJbQbeHwGTrOldLmR9-sOxRgCteOauDhxmJ48eo07W42hx62PujN4G_3_v-fRPGdvnBuabf-ITpi7MMbcjaaoT06C_L7OxjEYWCxVIzn8DzYi35g</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Brauer, R.B</creator><creator>Marx, T</creator><creator>Ulm, K</creator><creator>Stangl, M.J</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100601</creationdate><title>Effect of Perioperative Administration of a Drug Regimen on the Primary Function of Human Renal Allografts</title><author>Brauer, R.B ; Marx, T ; Ulm, K ; Stangl, M.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-286e5af6654bbca888676e10075734e2cfee4090898cce6b806435093c25f1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Alprostadil - administration & dosage</topic><topic>Alprostadil - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cadaver</topic><topic>Diuretics - administration & dosage</topic><topic>Diuretics - therapeutic use</topic><topic>Dopamine - administration & dosage</topic><topic>Dopamine - therapeutic use</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Furosemide - administration & dosage</topic><topic>Furosemide - therapeutic use</topic><topic>Graft Rejection - epidemiology</topic><topic>Graft Rejection - prevention & control</topic><topic>Humans</topic><topic>Intraoperative Period</topic><topic>Kidney Transplantation - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Renal Dialysis - statistics & numerical data</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue Donors</topic><topic>Tissue, organ and graft immunology</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brauer, R.B</creatorcontrib><creatorcontrib>Marx, T</creatorcontrib><creatorcontrib>Ulm, K</creatorcontrib><creatorcontrib>Stangl, M.J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brauer, R.B</au><au>Marx, T</au><au>Ulm, K</au><au>Stangl, M.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Perioperative Administration of a Drug Regimen on the Primary Function of Human Renal Allografts</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>42</volume><issue>5</issue><spage>1523</spage><epage>1525</epage><pages>1523-1525</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Abstract Delayed graft function (DGF) has one of the greatest effects on short- and long-term outcomes of cadaveric renal allografts. Ischemia reperfusion injury in the context of cold ischemia time and acute calcineurin inhibitor (CNI) nephrotoxicity is a major factor predisposing to DGF. A drug regimen consisting of prostaglandin E1 (PGE1 ) furosemide and dopamine has been used to reduce DGF after kidney transplantation. Prostaglandin E1 has multiple anti-ischemic and tissue-protective abilities, furosemide improves diuresis, and dopamine augments renal blood flow and urinary volume. To evaluate a potential positive effect of this drug regimen on the primary function of cadaveric renal allografts, we performed a retrospective single-center study that compared 100 patients who received this regimen with a control group. The results showed no significant improvement in renal function. In contrast, plasma levels of creatinine and urea were increased in the drug regimen group. 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| subjects | Adult Alprostadil - administration & dosage Alprostadil - therapeutic use Biological and medical sciences Cadaver Diuretics - administration & dosage Diuretics - therapeutic use Dopamine - administration & dosage Dopamine - therapeutic use Female Fundamental and applied biological sciences. Psychology Fundamental immunology Furosemide - administration & dosage Furosemide - therapeutic use Graft Rejection - epidemiology Graft Rejection - prevention & control Humans Intraoperative Period Kidney Transplantation - physiology Male Medical sciences Middle Aged Renal Dialysis - statistics & numerical data Retrospective Studies Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue Donors Tissue, organ and graft immunology Transplantation, Homologous |
| title | Effect of Perioperative Administration of a Drug Regimen on the Primary Function of Human Renal Allografts |
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