Activation of Adenosine A2A Receptor Attenuates Inflammatory Response in a Rat Model of Small-for-Size Liver Transplantation

Abstract Objective To investigate the effects of adenosine A2A receptor (A2AR) activation on inflammatory responses in small-for-size liver transplantation. Materials and Methods A rat orthotopic liver transplantation model was established using 35% grafts. Expression of A2AR in liver grafts was ass...

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Veröffentlicht in:	Transplantation proceedings 2010-06, Vol.42 (5), p.1915-1920
Hauptverfasser:	Tang, L.-M, Zhu, J.-F, Wang, F, Qian, J, Zhu, J, Mo, Q, Lu, H.-H, Li, G.-Q, Wang, X.-H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine A2 Receptor Agonists Adenosine A2 Receptor Antagonists Alanine Transaminase - blood Animals Biological and medical sciences Chemokine CXCL2 - metabolism Cytokines - metabolism Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Fundamental immunology Inflammation - prevention & control Intercellular Adhesion Molecule-1 - metabolism Liver - anatomy & histology Liver - enzymology Liver Transplantation - methods Liver Transplantation - physiology Liver, biliary tract, pancreas, portal circulation, spleen Male Medical sciences NF-kappa B - metabolism Organ Size Peroxidase - metabolism Phenethylamines - pharmacology Phosphorylation Rats Rats, Inbred Lew Receptor, Adenosine A2A - genetics Receptor, Adenosine A2A - metabolism Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Tissue, organ and graft immunology Triazines - pharmacology Triazoles - pharmacology Tumor Necrosis Factor-alpha - metabolism
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