Effects of deep-frying oil on blood pressure and oxidative stress in spontaneously hypertensive and normotensive rats
Abstract Objective Ingestion of deep-frying oil has been reported to cause physiologic and histologic changes in experimental animals' tissue, increase the oxidative stress, and possibly lead to death. The purpose of this study was to investigate the effect of deep-frying oil on oxidative stres...
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| Veröffentlicht in: | Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2010-03, Vol.26 (3), p.331-336 |
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| creator | Yen, Pei-Ling, M.S Chen, Bing-Huei, Ph.D Yang, Feili Lo, Ph.D Lu, Yi-Fa, Ph.D |
| description | Abstract Objective Ingestion of deep-frying oil has been reported to cause physiologic and histologic changes in experimental animals' tissue, increase the oxidative stress, and possibly lead to death. The purpose of this study was to investigate the effect of deep-frying oil on oxidative stress and blood pressure in spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats. Methods Deep-frying oil was prepared by frying fresh soybean oil at 180 ± 5°C for 8 h each day, for 4 consecutive days. Male SHR and WKY rats were fed diets containing 15% fresh soybean oil or deep-frying oil (DO) for 10 wk. Results Rats ingesting the DO diet had lower feed efficiency and higher relative liver and kidney weights but deep frying had no significant influence on blood pressure in WKY or SHR rats. The DO diet had no effect on plasma renin activity, aldosterone content, or tissue angiotension-I–converting enzyme activity. WKY rats fed the DO diet showed significantly increased urinary thromboxane B2 and 8-iso-prostaglandin F2α excretion, but not urinary 6-keto-prostaglandin F1α excretion. Diets containing deep-frying oil resulted in increased plasma thiobarbituric acid-reactive substances and nitric oxide contents and decreased plasma total antioxidant capacity in SHR and WKY rats. Conclusion The ingestion of deep-frying oil seemed not to influence blood pressure or its related parameters, but altered eicosanoid metabolism and elevated oxidative stress in SHR and WKY rats. |
| doi_str_mv | 10.1016/j.nut.2009.04.020 |
| format | Article |
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The purpose of this study was to investigate the effect of deep-frying oil on oxidative stress and blood pressure in spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats. Methods Deep-frying oil was prepared by frying fresh soybean oil at 180 ± 5°C for 8 h each day, for 4 consecutive days. Male SHR and WKY rats were fed diets containing 15% fresh soybean oil or deep-frying oil (DO) for 10 wk. Results Rats ingesting the DO diet had lower feed efficiency and higher relative liver and kidney weights but deep frying had no significant influence on blood pressure in WKY or SHR rats. The DO diet had no effect on plasma renin activity, aldosterone content, or tissue angiotension-I–converting enzyme activity. WKY rats fed the DO diet showed significantly increased urinary thromboxane B2 and 8-iso-prostaglandin F2α excretion, but not urinary 6-keto-prostaglandin F1α excretion. Diets containing deep-frying oil resulted in increased plasma thiobarbituric acid-reactive substances and nitric oxide contents and decreased plasma total antioxidant capacity in SHR and WKY rats. Conclusion The ingestion of deep-frying oil seemed not to influence blood pressure or its related parameters, but altered eicosanoid metabolism and elevated oxidative stress in SHR and WKY rats.</description><identifier>ISSN: 0899-9007</identifier><identifier>EISSN: 1873-1244</identifier><identifier>DOI: 10.1016/j.nut.2009.04.020</identifier><identifier>PMID: 19592221</identifier><identifier>CODEN: NUTRER</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Antioxidants ; Antioxidants - metabolism ; Biological and medical sciences ; Blood pressure ; Blood Pressure - drug effects ; Cooking ; Deep-frying oil ; Diet ; Dietary Fats - administration & dosage ; Eicosanoids ; Energy Metabolism - drug effects ; Enzymatic activity ; Excretion ; Feed conversion ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; Glycine max - chemistry ; Hot Temperature ; Hypertension ; Hypertension - metabolism ; Hypertension - physiopathology ; Ingestion ; Kidney - drug effects ; Liver - drug effects ; Male ; Nitric oxide ; Nitric Oxide - blood ; Oils & fats ; Organ Size - drug effects ; Oxidative stress ; Oxidative Stress - drug effects ; Prostaglandins F, Synthetic - urine ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Reference Values ; Rodents ; Soybean oil ; Soybean Oil - pharmacology ; Soybeans ; Spontaneously hypertensive rats ; Thiobarbituric Acid Reactive Substances ; Thromboxane B2 - urine ; Vegetable oils ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Nutrition (Burbank, Los Angeles County, Calif.), 2010-03, Vol.26 (3), p.331-336</ispartof><rights>2010</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010. Published by Elsevier Inc.</rights><rights>Copyright Elsevier Limited Mar 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-e205e7204726a0a0b04d309b0edf4ff39d0988ba41a0cab53136d69e3b27781e3</citedby><cites>FETCH-LOGICAL-c465t-e205e7204726a0a0b04d309b0edf4ff39d0988ba41a0cab53136d69e3b27781e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1130249756?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993,64383,64385,64387,72239</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22400584$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19592221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yen, Pei-Ling, M.S</creatorcontrib><creatorcontrib>Chen, Bing-Huei, Ph.D</creatorcontrib><creatorcontrib>Yang, Feili Lo, Ph.D</creatorcontrib><creatorcontrib>Lu, Yi-Fa, Ph.D</creatorcontrib><title>Effects of deep-frying oil on blood pressure and oxidative stress in spontaneously hypertensive and normotensive rats</title><title>Nutrition (Burbank, Los Angeles County, Calif.)</title><addtitle>Nutrition</addtitle><description>Abstract Objective Ingestion of deep-frying oil has been reported to cause physiologic and histologic changes in experimental animals' tissue, increase the oxidative stress, and possibly lead to death. The purpose of this study was to investigate the effect of deep-frying oil on oxidative stress and blood pressure in spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats. Methods Deep-frying oil was prepared by frying fresh soybean oil at 180 ± 5°C for 8 h each day, for 4 consecutive days. Male SHR and WKY rats were fed diets containing 15% fresh soybean oil or deep-frying oil (DO) for 10 wk. Results Rats ingesting the DO diet had lower feed efficiency and higher relative liver and kidney weights but deep frying had no significant influence on blood pressure in WKY or SHR rats. The DO diet had no effect on plasma renin activity, aldosterone content, or tissue angiotension-I–converting enzyme activity. WKY rats fed the DO diet showed significantly increased urinary thromboxane B2 and 8-iso-prostaglandin F2α excretion, but not urinary 6-keto-prostaglandin F1α excretion. Diets containing deep-frying oil resulted in increased plasma thiobarbituric acid-reactive substances and nitric oxide contents and decreased plasma total antioxidant capacity in SHR and WKY rats. Conclusion The ingestion of deep-frying oil seemed not to influence blood pressure or its related parameters, but altered eicosanoid metabolism and elevated oxidative stress in SHR and WKY rats.</description><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Cooking</subject><subject>Deep-frying oil</subject><subject>Diet</subject><subject>Dietary Fats - administration & dosage</subject><subject>Eicosanoids</subject><subject>Energy Metabolism - drug effects</subject><subject>Enzymatic activity</subject><subject>Excretion</subject><subject>Feed conversion</subject><subject>Feeding. 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Academic</collection><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yen, Pei-Ling, M.S</au><au>Chen, Bing-Huei, Ph.D</au><au>Yang, Feili Lo, Ph.D</au><au>Lu, Yi-Fa, Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of deep-frying oil on blood pressure and oxidative stress in spontaneously hypertensive and normotensive rats</atitle><jtitle>Nutrition (Burbank, Los Angeles County, Calif.)</jtitle><addtitle>Nutrition</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>26</volume><issue>3</issue><spage>331</spage><epage>336</epage><pages>331-336</pages><issn>0899-9007</issn><eissn>1873-1244</eissn><coden>NUTRER</coden><abstract>Abstract Objective Ingestion of deep-frying oil has been reported to cause physiologic and histologic changes in experimental animals' tissue, increase the oxidative stress, and possibly lead to death. The purpose of this study was to investigate the effect of deep-frying oil on oxidative stress and blood pressure in spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats. Methods Deep-frying oil was prepared by frying fresh soybean oil at 180 ± 5°C for 8 h each day, for 4 consecutive days. Male SHR and WKY rats were fed diets containing 15% fresh soybean oil or deep-frying oil (DO) for 10 wk. Results Rats ingesting the DO diet had lower feed efficiency and higher relative liver and kidney weights but deep frying had no significant influence on blood pressure in WKY or SHR rats. The DO diet had no effect on plasma renin activity, aldosterone content, or tissue angiotension-I–converting enzyme activity. WKY rats fed the DO diet showed significantly increased urinary thromboxane B2 and 8-iso-prostaglandin F2α excretion, but not urinary 6-keto-prostaglandin F1α excretion. Diets containing deep-frying oil resulted in increased plasma thiobarbituric acid-reactive substances and nitric oxide contents and decreased plasma total antioxidant capacity in SHR and WKY rats. Conclusion The ingestion of deep-frying oil seemed not to influence blood pressure or its related parameters, but altered eicosanoid metabolism and elevated oxidative stress in SHR and WKY rats.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>19592221</pmid><doi>10.1016/j.nut.2009.04.020</doi><tpages>6</tpages></addata></record> |
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| ispartof | Nutrition (Burbank, Los Angeles County, Calif.), 2010-03, Vol.26 (3), p.331-336 |
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| subjects | Animals Antioxidants Antioxidants - metabolism Biological and medical sciences Blood pressure Blood Pressure - drug effects Cooking Deep-frying oil Diet Dietary Fats - administration & dosage Eicosanoids Energy Metabolism - drug effects Enzymatic activity Excretion Feed conversion Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology Glycine max - chemistry Hot Temperature Hypertension Hypertension - metabolism Hypertension - physiopathology Ingestion Kidney - drug effects Liver - drug effects Male Nitric oxide Nitric Oxide - blood Oils & fats Organ Size - drug effects Oxidative stress Oxidative Stress - drug effects Prostaglandins F, Synthetic - urine Rats Rats, Inbred SHR Rats, Inbred WKY Reference Values Rodents Soybean oil Soybean Oil - pharmacology Soybeans Spontaneously hypertensive rats Thiobarbituric Acid Reactive Substances Thromboxane B2 - urine Vegetable oils Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Effects of deep-frying oil on blood pressure and oxidative stress in spontaneously hypertensive and normotensive rats |
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