Effect of carvedilol on ryanodine receptor in heart failure

The release of intracellular stores of Ca(2+) occurs virtually in all types of cells by a means of amplifying external signals that modulate intracellular signaling events. In cardiac myocytes, type 2 ryanodine receptor (RyR(2)) is activated during excitation-contraction (E-C) coupling by Ca(2+)-ind...

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Veröffentlicht in:	Zhonghua er ke za zhi 2005-08, Vol.43 (8), p.603-607
Hauptverfasser:	Li, Rong, Yi, Qi-jian, Qian, Yong-ru, Liu, Xiao-yan
Format:	Artikel
Sprache:	chi
Schlagworte:	Adrenergic beta-Antagonists - pharmacology Animals Animals, Newborn Calcium - metabolism Calcium Signaling - drug effects Calcium-Transporting ATPases - antagonists & inhibitors Carbazoles - pharmacology Disease Models, Animal Heart Failure - diagnostic imaging Heart Failure - drug therapy Heart Failure - metabolism Myocardial Contraction - drug effects Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Propanolamines - pharmacology Rats Rats, Wistar Ryanodine Receptor Calcium Release Channel - metabolism Sarcoplasmic Reticulum - drug effects Sarcoplasmic Reticulum - metabolism Spectrometry, Fluorescence Thapsigargin - pharmacology Ultrasonography
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