Allopregnanolone effects on astrogliosis induced by hypoxia in organotypic cultures of striatum, hippocampus, and neocortex

Abstract Perinatal asphyxia occurs in approximately 0.3% full-term newborn babies, and this percentage has not decreased despite medical advances. There are now evidences indicating that neurosteroids are important in neurodevelopment showing neuroprotective effects. We studied the potential protect...

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Veröffentlicht in:	Brain research 2009-11, Vol.1303, p.1-7
Hauptverfasser:	Kruse, María Sol, Rey, Mariana, Barutta, Joaquín, Coirini, Héctor
Format:	Artikel
Sprache:	eng
Schlagworte:	Allopregnanolone Animals Animals, Newborn Astrocytes - drug effects Astrocytes - metabolism Biological and medical sciences Biomarkers - analysis Biomarkers - metabolism Cell Survival - drug effects Cell Survival - physiology Corpus Striatum - drug effects Corpus Striatum - metabolism Corpus Striatum - physiopathology Cytoprotection - drug effects Cytoprotection - physiology Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Glial Fibrillary Acidic Protein - analysis Glial Fibrillary Acidic Protein - metabolism Gliosis - drug therapy Gliosis - metabolism Gliosis - physiopathology Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiopathology Hypoxia Hypoxia, Brain - drug therapy Hypoxia, Brain - metabolism Hypoxia, Brain - physiopathology Isolated neuron and nerve. Neuroglia L-Lactate Dehydrogenase - drug effects L-Lactate Dehydrogenase - metabolism Neocortex Neocortex - drug effects Neocortex - metabolism Neocortex - physiopathology Nerve Degeneration - drug therapy Nerve Degeneration - metabolism Nerve Degeneration - physiopathology Neurology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Organ Culture Techniques Organotypic culture Pregnanolone - pharmacology Pregnanolone - therapeutic use Prosencephalon - drug effects Prosencephalon - metabolism Prosencephalon - physiopathology Rats Rats, Sprague-Dawley Striatum Vertebrates: nervous system and sense organs
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