Effect of caerulein on expression of the immediate-early genes c- fos and zif/268 in the rat brain
The effect of caerulein, an analog of cholecystokinin-8, on expression of the immediate-early genes c- fos and zif/268 was studied in the rat brain using Northern blot analysis and an in situ hybridization technique. Intraperitoneal injection of caerulein did not change the basal c- fos and zif/268...
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| Veröffentlicht in: | Neuroscience letters 1992-01, Vol.145 (2), p.205-208 |
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| container_title | Neuroscience letters |
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| creator | Miyoshi, Rie Kito, Shozo Muraki, Takamura Weiser, Michael Joh, Tong H. |
| description | The effect of caerulein, an analog of cholecystokinin-8, on expression of the immediate-early genes c-
fos and zif/268 was studied in the rat brain using Northern blot analysis and an in situ hybridization technique. Intraperitoneal injection of caerulein did not change the basal c-
fos and zif/268 expression. Administration of the convulsant, pentylenetetrazole (PTZ), caused a dramatic increase of c-
fos and zif/268 mRNAs in the hippocampus and dentate gyrus. Pretreatment with caerulein suppressed the PTZ-induced c-
fos and zif/268 expression. It is considered that systemically administrated caerulein modifies neuronal activities by exerting a suppressed effect on induction of the immediate-early genes. |
| doi_str_mv | 10.1016/0304-3940(92)90023-Z |
| format | Article |
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fos and zif/268 was studied in the rat brain using Northern blot analysis and an in situ hybridization technique. Intraperitoneal injection of caerulein did not change the basal c-
fos and zif/268 expression. Administration of the convulsant, pentylenetetrazole (PTZ), caused a dramatic increase of c-
fos and zif/268 mRNAs in the hippocampus and dentate gyrus. Pretreatment with caerulein suppressed the PTZ-induced c-
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fos and zif/268 was studied in the rat brain using Northern blot analysis and an in situ hybridization technique. Intraperitoneal injection of caerulein did not change the basal c-
fos and zif/268 expression. Administration of the convulsant, pentylenetetrazole (PTZ), caused a dramatic increase of c-
fos and zif/268 mRNAs in the hippocampus and dentate gyrus. Pretreatment with caerulein suppressed the PTZ-induced c-
fos and zif/268 expression. It is considered that systemically administrated caerulein modifies neuronal activities by exerting a suppressed effect on induction of the immediate-early genes.</description><subject>Animals</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Autoradiography</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Blotting, Northern</subject><subject>Brain Chemistry - drug effects</subject><subject>c- fos mRNA</subject><subject>Caerulein</subject><subject>Ceruletide - pharmacology</subject><subject>DNA Probes</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Genes, fos - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>In Situ Hybridization</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Neuropharmacology</subject><subject>Pentylenetetrazole</subject><subject>Pentylenetetrazole - pharmacology</subject><subject>Pharmacology. 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fos and zif/268 was studied in the rat brain using Northern blot analysis and an in situ hybridization technique. Intraperitoneal injection of caerulein did not change the basal c-
fos and zif/268 expression. Administration of the convulsant, pentylenetetrazole (PTZ), caused a dramatic increase of c-
fos and zif/268 mRNAs in the hippocampus and dentate gyrus. Pretreatment with caerulein suppressed the PTZ-induced c-
fos and zif/268 expression. It is considered that systemically administrated caerulein modifies neuronal activities by exerting a suppressed effect on induction of the immediate-early genes.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>1465218</pmid><doi>10.1016/0304-3940(92)90023-Z</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroscience letters, 1992-01, Vol.145 (2), p.205-208 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Autoradiography Base Sequence Biological and medical sciences Blotting, Northern Brain Chemistry - drug effects c- fos mRNA Caerulein Ceruletide - pharmacology DNA Probes Gene Expression Regulation - drug effects Genes, fos - drug effects Hippocampus - metabolism In Situ Hybridization Male Medical sciences Molecular Sequence Data Neuropharmacology Pentylenetetrazole Pentylenetetrazole - pharmacology Pharmacology. Drug treatments Rat Rats Rats, Wistar zif/268 mRNA |
| title | Effect of caerulein on expression of the immediate-early genes c- fos and zif/268 in the rat brain |
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