Crushed Clopidogrel Administered via Nasogastric Tube Has Faster and Greater Absorption than Oral Whole Tablets

Objectives: To compare the absorption of 300 mg clopidogrel administered crushed via nasogastric (NG) tube versus whole tablets taken orally in healthy volunteers. Background: Earlier antiplatelet therapy has proven benefits in treatment of myocardial infarction and in patients undergoing PCI. Aspir...

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Veröffentlicht in:	Journal of interventional cardiology 2009-08, Vol.22 (4), p.385-389
Hauptverfasser:	ZAFAR, M. UROOJ, FARKOUH, MICHAEL E., FUSTER, VALENTIN, CHESEBRO, JAMES H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Area Under Curve Biological Availability Confidence Intervals Female Humans Intubation, Gastrointestinal Male Odds Ratio Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - pharmacokinetics Platelet Aggregation Inhibitors - therapeutic use Tablets Ticlopidine - administration & dosage Ticlopidine - analogs & derivatives Ticlopidine - pharmacokinetics Ticlopidine - therapeutic use
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