Oncogenic Activating Mutations Are Associated with Local Copy Gain

Although activating mutations and gains in copy number are key mechanisms for oncogene activation, the relationship between the two is not well understood. In this study, we focused on KRAS copy gains and mutations in non–small cell lung cancer. We found that KRAS copy gains occur more frequently in...

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Veröffentlicht in:	Molecular cancer research 2009-08, Vol.7 (8), p.1244-1252
Hauptverfasser:	Modrek, Barmak, Ge, Lin, Pandita, Ajay, Lin, Eva, Mohan, Sankar, Yue, Peng, Guerrero, Steve, Lin, William M, Pham, Thinh, Modrusan, Zora, Seshagiri, Somasekar, Stern, Howard M, Waring, Paul, Garraway, Levi A, Chant, John, Stokoe, David, Cavet, Guy
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Carcinoma, Non-Small-Cell Lung - genetics Cell Line, Tumor Chromosome Aberrations copy gain Gene Dosage - genetics Gene Expression Regulation, Neoplastic Humans In Situ Hybridization, Fluorescence KRAS Lung Neoplasms - genetics Mutant Proteins - metabolism Mutation - genetics Oncogenes - genetics Polymorphism, Single Nucleotide - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism ras Proteins - genetics ras Proteins - metabolism Receptor, Epidermal Growth Factor - genetics RNA, Messenger - genetics RNA, Messenger - metabolism somatic mutation
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