Calcium metabolism in eight dogs with hypoadrenocorticism
Hypoadrenocorticism is a well-described endocrinopathy in dogs that results from deficient production and secretion of glucocorticoids and/or mineralocorticoids. Although hyperkalaemia, hyponatraemia and hypochloraemia are the most common electrolyte disturbances, hypercalcaemia also occurs in appro...
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| Veröffentlicht in: | Journal of small animal practice 2009-08, Vol.50 (8), p.426-430 |
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| creator | Gow, A.G Gow, D.J Bell, R Simpson, J.W Chandler, M.L Evans, H Berry, J.L Herrtage, M.E Mellanby, R.J |
| description | Hypoadrenocorticism is a well-described endocrinopathy in dogs that results from deficient production and secretion of glucocorticoids and/or mineralocorticoids. Although hyperkalaemia, hyponatraemia and hypochloraemia are the most common electrolyte disturbances, hypercalcaemia also occurs in approximately 30 per cent of cases. The pathogenesis of hypercalcaemia in dogs with hypoadrenocorticism is unknown. This case series reports ionised calcium, parathyroid hormone, parathyroid hormone-related protein and vitamin D metabolite concentrations that were measured in eight dogs with concurrent hypercalcaemia and hypoadrenocorticism. Ionised calcium was increased in five of seven dogs with hypercalcaemia associated with hypoadrenocorticism. Parathyroid hormone, parathyroid hormone-related protein and 1,25 dihydroxyvitamin D concentrations were within their reference ranges in seven of eight dogs, six of seven cases and six of seven dogs, respectively. This case series highlights that hypercalcaemia associated with hypoadrenocorticism is rarely associated with increases in plasma parathyroid hormone, parathyroid hormone-related protein or serum 1,25 dihydroxyvitamin D concentrations. |
| doi_str_mv | 10.1111/j.1748-5827.2009.00757.x |
| format | Article |
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Although hyperkalaemia, hyponatraemia and hypochloraemia are the most common electrolyte disturbances, hypercalcaemia also occurs in approximately 30 per cent of cases. The pathogenesis of hypercalcaemia in dogs with hypoadrenocorticism is unknown. This case series reports ionised calcium, parathyroid hormone, parathyroid hormone-related protein and vitamin D metabolite concentrations that were measured in eight dogs with concurrent hypercalcaemia and hypoadrenocorticism. Ionised calcium was increased in five of seven dogs with hypercalcaemia associated with hypoadrenocorticism. Parathyroid hormone, parathyroid hormone-related protein and 1,25 dihydroxyvitamin D concentrations were within their reference ranges in seven of eight dogs, six of seven cases and six of seven dogs, respectively. This case series highlights that hypercalcaemia associated with hypoadrenocorticism is rarely associated with increases in plasma parathyroid hormone, parathyroid hormone-related protein or serum 1,25 dihydroxyvitamin D concentrations.</description><identifier>ISSN: 0022-4510</identifier><identifier>EISSN: 1748-5827</identifier><identifier>DOI: 10.1111/j.1748-5827.2009.00757.x</identifier><identifier>PMID: 19689671</identifier><language>eng</language><publisher>Oxford, UK: Oxford, UK : Blackwell Publishing Ltd</publisher><subject>adrenal glands ; Adrenal Insufficiency - metabolism ; Adrenal Insufficiency - veterinary ; Adrenocorticotropic Hormone - blood ; Animals ; calcium ; Calcium - blood ; Calcium - metabolism ; case studies ; deficiency diseases ; dihydroxyvitamin D ; dog diseases ; Dog Diseases - metabolism ; Dogs ; electrolytes ; Female ; glucocorticoids ; Hydrocortisone - blood ; hypercalcemia ; hyperkalemia ; hypoadrenocorticism ; hypochloremia ; hyponatremia ; ionization ; Male ; metabolism ; metabolites ; mineralocorticoids ; parathyroid hormone ; Parathyroid Hormone - blood ; pathogenesis ; vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood</subject><ispartof>Journal of small animal practice, 2009-08, Vol.50 (8), p.426-430</ispartof><rights>2009 British Small Animal Veterinary Association</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4617-8a6dac8a1182946e50fd1c9d293c9c7b7317724cf106d85fd0b6020bab48f75a3</citedby><cites>FETCH-LOGICAL-c4617-8a6dac8a1182946e50fd1c9d293c9c7b7317724cf106d85fd0b6020bab48f75a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1748-5827.2009.00757.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1748-5827.2009.00757.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19689671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gow, A.G</creatorcontrib><creatorcontrib>Gow, D.J</creatorcontrib><creatorcontrib>Bell, R</creatorcontrib><creatorcontrib>Simpson, J.W</creatorcontrib><creatorcontrib>Chandler, M.L</creatorcontrib><creatorcontrib>Evans, H</creatorcontrib><creatorcontrib>Berry, J.L</creatorcontrib><creatorcontrib>Herrtage, M.E</creatorcontrib><creatorcontrib>Mellanby, R.J</creatorcontrib><title>Calcium metabolism in eight dogs with hypoadrenocorticism</title><title>Journal of small animal practice</title><addtitle>J Small Anim Pract</addtitle><description>Hypoadrenocorticism is a well-described endocrinopathy in dogs that results from deficient production and secretion of glucocorticoids and/or mineralocorticoids. Although hyperkalaemia, hyponatraemia and hypochloraemia are the most common electrolyte disturbances, hypercalcaemia also occurs in approximately 30 per cent of cases. The pathogenesis of hypercalcaemia in dogs with hypoadrenocorticism is unknown. This case series reports ionised calcium, parathyroid hormone, parathyroid hormone-related protein and vitamin D metabolite concentrations that were measured in eight dogs with concurrent hypercalcaemia and hypoadrenocorticism. Ionised calcium was increased in five of seven dogs with hypercalcaemia associated with hypoadrenocorticism. Parathyroid hormone, parathyroid hormone-related protein and 1,25 dihydroxyvitamin D concentrations were within their reference ranges in seven of eight dogs, six of seven cases and six of seven dogs, respectively. This case series highlights that hypercalcaemia associated with hypoadrenocorticism is rarely associated with increases in plasma parathyroid hormone, parathyroid hormone-related protein or serum 1,25 dihydroxyvitamin D concentrations.</description><subject>adrenal glands</subject><subject>Adrenal Insufficiency - metabolism</subject><subject>Adrenal Insufficiency - veterinary</subject><subject>Adrenocorticotropic Hormone - blood</subject><subject>Animals</subject><subject>calcium</subject><subject>Calcium - blood</subject><subject>Calcium - metabolism</subject><subject>case studies</subject><subject>deficiency diseases</subject><subject>dihydroxyvitamin D</subject><subject>dog diseases</subject><subject>Dog Diseases - metabolism</subject><subject>Dogs</subject><subject>electrolytes</subject><subject>Female</subject><subject>glucocorticoids</subject><subject>Hydrocortisone - blood</subject><subject>hypercalcemia</subject><subject>hyperkalemia</subject><subject>hypoadrenocorticism</subject><subject>hypochloremia</subject><subject>hyponatremia</subject><subject>ionization</subject><subject>Male</subject><subject>metabolism</subject><subject>metabolites</subject><subject>mineralocorticoids</subject><subject>parathyroid hormone</subject><subject>Parathyroid Hormone - blood</subject><subject>pathogenesis</subject><subject>vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><issn>0022-4510</issn><issn>1748-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v0zAYgC0EYt3gL0BO7JTw-iP-OHCYKjY-JkAqE0fLcZzWJamLnWrtv59LqnGb8MW2_DyvpQehAkOF83q_rrBgsqwlERUBUBWAqEW1f4Zmjw_P0QyAkJLVGM7QeUrrfOVMwEt0hhWXigs8Q2pueut3QzG40TSh92ko_KZwfrkaizYsU3Hvx1WxOmyDaaPbBBvi6G3GXqEXnemTe33aL9Dd9cef80_l7febz_Or29IyjkUpDW-NlQZjSRTjroauxVa1RFGrrGgExUIQZjsMvJV110LDgUBjGiY7URt6gS6nudsY_uxcGvXgk3V9bzYu7JIWlCoBTPJMvnuSJCAk5ZhkUE6gjSGl6Dq9jX4w8aAx6GNgvdbHjvrYUR8D67-B9T6rb05_7JrBtf_EU9EMfJiAe9-7w38P1l8WVz_yKfvl5Ps0uv2jb-JvzQUVtf717UbDQi0Yhmv9NfNvJ74zQZtl9EnfLQhgCphzWgtGHwCMv6D4</recordid><startdate>200908</startdate><enddate>200908</enddate><creator>Gow, A.G</creator><creator>Gow, D.J</creator><creator>Bell, R</creator><creator>Simpson, J.W</creator><creator>Chandler, M.L</creator><creator>Evans, H</creator><creator>Berry, J.L</creator><creator>Herrtage, M.E</creator><creator>Mellanby, R.J</creator><general>Oxford, UK : Blackwell Publishing Ltd</general><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>200908</creationdate><title>Calcium metabolism in eight dogs with hypoadrenocorticism</title><author>Gow, A.G ; Gow, D.J ; Bell, R ; Simpson, J.W ; Chandler, M.L ; Evans, H ; Berry, J.L ; Herrtage, M.E ; Mellanby, R.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4617-8a6dac8a1182946e50fd1c9d293c9c7b7317724cf106d85fd0b6020bab48f75a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>adrenal glands</topic><topic>Adrenal Insufficiency - metabolism</topic><topic>Adrenal Insufficiency - veterinary</topic><topic>Adrenocorticotropic Hormone - blood</topic><topic>Animals</topic><topic>calcium</topic><topic>Calcium - blood</topic><topic>Calcium - metabolism</topic><topic>case studies</topic><topic>deficiency diseases</topic><topic>dihydroxyvitamin D</topic><topic>dog diseases</topic><topic>Dog Diseases - metabolism</topic><topic>Dogs</topic><topic>electrolytes</topic><topic>Female</topic><topic>glucocorticoids</topic><topic>Hydrocortisone - blood</topic><topic>hypercalcemia</topic><topic>hyperkalemia</topic><topic>hypoadrenocorticism</topic><topic>hypochloremia</topic><topic>hyponatremia</topic><topic>ionization</topic><topic>Male</topic><topic>metabolism</topic><topic>metabolites</topic><topic>mineralocorticoids</topic><topic>parathyroid hormone</topic><topic>Parathyroid Hormone - blood</topic><topic>pathogenesis</topic><topic>vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gow, A.G</creatorcontrib><creatorcontrib>Gow, D.J</creatorcontrib><creatorcontrib>Bell, R</creatorcontrib><creatorcontrib>Simpson, J.W</creatorcontrib><creatorcontrib>Chandler, M.L</creatorcontrib><creatorcontrib>Evans, H</creatorcontrib><creatorcontrib>Berry, J.L</creatorcontrib><creatorcontrib>Herrtage, M.E</creatorcontrib><creatorcontrib>Mellanby, R.J</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of small animal practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gow, A.G</au><au>Gow, D.J</au><au>Bell, R</au><au>Simpson, J.W</au><au>Chandler, M.L</au><au>Evans, H</au><au>Berry, J.L</au><au>Herrtage, M.E</au><au>Mellanby, R.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Calcium metabolism in eight dogs with hypoadrenocorticism</atitle><jtitle>Journal of small animal practice</jtitle><addtitle>J Small Anim Pract</addtitle><date>2009-08</date><risdate>2009</risdate><volume>50</volume><issue>8</issue><spage>426</spage><epage>430</epage><pages>426-430</pages><issn>0022-4510</issn><eissn>1748-5827</eissn><abstract>Hypoadrenocorticism is a well-described endocrinopathy in dogs that results from deficient production and secretion of glucocorticoids and/or mineralocorticoids. Although hyperkalaemia, hyponatraemia and hypochloraemia are the most common electrolyte disturbances, hypercalcaemia also occurs in approximately 30 per cent of cases. The pathogenesis of hypercalcaemia in dogs with hypoadrenocorticism is unknown. This case series reports ionised calcium, parathyroid hormone, parathyroid hormone-related protein and vitamin D metabolite concentrations that were measured in eight dogs with concurrent hypercalcaemia and hypoadrenocorticism. Ionised calcium was increased in five of seven dogs with hypercalcaemia associated with hypoadrenocorticism. Parathyroid hormone, parathyroid hormone-related protein and 1,25 dihydroxyvitamin D concentrations were within their reference ranges in seven of eight dogs, six of seven cases and six of seven dogs, respectively. 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| subjects | adrenal glands Adrenal Insufficiency - metabolism Adrenal Insufficiency - veterinary Adrenocorticotropic Hormone - blood Animals calcium Calcium - blood Calcium - metabolism case studies deficiency diseases dihydroxyvitamin D dog diseases Dog Diseases - metabolism Dogs electrolytes Female glucocorticoids Hydrocortisone - blood hypercalcemia hyperkalemia hypoadrenocorticism hypochloremia hyponatremia ionization Male metabolism metabolites mineralocorticoids parathyroid hormone Parathyroid Hormone - blood pathogenesis vitamin D Vitamin D - analogs & derivatives Vitamin D - blood |
| title | Calcium metabolism in eight dogs with hypoadrenocorticism |
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