Stimulation of cardiac fatty acid oxidation by leptin is mediated by a nitric oxide–p38 MAPK-dependent mechanism

Leptin has previously been shown to stimulate fatty acid oxidation independent of AMP-activated protein kinase (AMPK). Nitric oxide and p38 mitogen activated protein kinase (MAPK) are known effectors of leptin signaling. The aim of the present study was to determine whether nitric oxide and p38 MAPK...

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Veröffentlicht in:	European journal of pharmacology 2009-09, Vol.617 (1), p.113-117
Hauptverfasser:	Sharma, Vijay, Mustafa, Sally, Patel, Natasha, Wambolt, Richard, Allard, Michael F., McNeill, John H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Fatty acid oxidation Fatty Acids - metabolism Glucose - metabolism Heart Heart - drug effects In Vitro Techniques Lactic Acid - biosynthesis Leptin Leptin - pharmacology Male Medical sciences Mitochondria - drug effects Mitochondria - metabolism Myocardium - metabolism Nitrates - metabolism Nitric oxide Nitric Oxide - metabolism Nitrites - metabolism Oxidation-Reduction - drug effects p38 MAPK p38 Mitogen-Activated Protein Kinases - metabolism Pharmacology. Drug treatments Phosphorylation - drug effects Rats Rats, Sprague-Dawley STAT3 Transcription Factor - metabolism
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