Aromatic Substitution Reaction of 2-Chloropyridines Catalyzed by Microsomal Glutathione S-Transferase 1

We investigated the substitution reaction of a series of 2-chloropyridine derivatives catalyzed by rat liver microsomal glutathione S-transferase 1. Various 2-chloropyridine derivatives were metabolized to the corresponding substituted glutathione conjugates via displacement of chlorine atom with gl...

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Veröffentlicht in:	Drug metabolism and disposition 2009-09, Vol.37 (9), p.1797-1800
Hauptverfasser:	Inoue, Kazuko, Ohe, Tomoyuki, Mori, Kenichi, Sagara, Takeshi, Ishii, Yasuyuki, Chiba, Masato
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chlorobenzenes - metabolism Chromatography, High Pressure Liquid Glutathione - metabolism Glutathione Transferase - metabolism Hydrocarbons, Aromatic - metabolism Mass Spectrometry Medical sciences Microsomes, Liver - enzymology Molecular Conformation Nitro Compounds - metabolism Pharmacology. Drug treatments Pyridines - chemistry Pyridines - metabolism Rats Spectrophotometry, Ultraviolet
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