Cutaneous distribution of plasmacytoid dendritic cells in lupus erythematosus. Selective tropism at the site of epithelial apoptotic damage

Abstract Recent evidences suggest a significant role of Plasmacytoid dendritic cells (PDC) role in the pathogenesis of lupus erythematosus (LE) via production of type I IFN. Taking advantage on the availability of multiple reagents (CD123, BDCA2, and CD2ap) specifically recognizing PDC on fixed tiss...

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Veröffentlicht in:	Immunobiology (1979) 2009-09, Vol.214 (9), p.877-886
Hauptverfasser:	Vermi, William, Lonardi, Silvia, Morassi, Mauro, Rossini, Cristina, Tardanico, Regina, Venturini, Marina, Sala, Raffaella, Tincani, Angela, Poliani, Pietro Luigi, Calzavara-Pinton, Pier Giacomo, Cerroni, Lorenzo, Santoro, Amerigo, Facchetti, Fabio
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Allergy and Immunology Apoptosis Cell Movement Chimerin Proteins - metabolism Cutaneous Dendritic Cells - immunology Dermis - immunology Dermis - pathology Humans Immunohistochemistry Interferon Interferon Type I - biosynthesis Kidney - immunology Kidney - pathology Lupus erythematosus Lupus Erythematosus, Cutaneous - immunology Lupus Erythematosus, Cutaneous - pathology Lysosomal Membrane Proteins - metabolism Neoplasm Proteins - metabolism Plasmacytoid dendritic cell Skin - immunology Skin - pathology T-Box Domain Proteins - metabolism
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