Enhancement of vascular endothelial growth factor–mediated angiogenesis in tamoxifen-resistant breast cancer cells: role of Pin1 overexpression

Acquired resistance to tamoxifen (TAM) is a serious therapeutic problem in breast cancer patients. Here, we found that TAM-resistant MCF-7 cells (TAMR-MCF-7 cells) produced higher levels of vascular endothelial growth factor (VEGF) than control MCF-7 cells. Molecular analyses using reporter genes an...

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Veröffentlicht in:	Molecular cancer therapeutics 2009-08, Vol.8 (8), p.2163-2171
Hauptverfasser:	Kim, Mi Ra, Choi, Hong Seok, Yang, Jin Won, Park, Byung Chul, Kim, Jung-Ae, Kang, Keon Wook
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Antineoplastic Agents, Hormonal - pharmacology Breast Neoplasms - blood supply Breast Neoplasms - genetics Breast Neoplasms - metabolism c-Jun/AP-1 Cell Line, Tumor Drug Resistance, Neoplasm Female HIF-1α Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism NIMA-Interacting Peptidylprolyl Isomerase Peptidylprolyl Isomerase - genetics Peptidylprolyl Isomerase - metabolism Pin1 Tamoxifen - pharmacology tamoxifen-resistant breast cancer Transcription Factor AP-1 - genetics Transcription Factor AP-1 - metabolism Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism VEGF
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