Antiretroviral therapy initiation during primary HIV infection enhances both CD127 expression and the proliferative capacity of HIV-specific CD8+ T cells

HIV-specific CD8+ T cells from patients with primary HIV infection (PHI) and after antiretroviral therapy initiation were evaluated for CD127 expression and proliferative capacity and were compared with cells from chronically-infected patients, including long-term nonprogressors and HIV controllers....

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Veröffentlicht in:	AIDS (London) 2009-08, Vol.23 (13), p.1649-1658
Hauptverfasser:	LECUROUX, Camille, GIRAULT, Isabelle, SINET, Martine, VENET, Alain, BOUTBOUL, François, URRUTIA, Alejandra, GOUJARD, Cécile, MEYER, Laurence, LAMBOTTE, Olivier, CHAIX, Marie-Laure, MARTINEZ, Valérie, AUTRAN, Brigitte
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease AIDS/HIV Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences CD4 Lymphocyte Count CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell Differentiation - immunology Cell Proliferation - drug effects Chronic Disease Disease Progression HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV Long-Term Survivors Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Immunophenotyping Infectious diseases Interleukin-7 Receptor alpha Subunit - blood Lymphocyte Activation - immunology Medical sciences Pharmacology. Drug treatments Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Viremia - immunology
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