Development of a novel expression, ZI MAX/K ZI, for determination of the counter-anion effect on the antimicrobial activity of tetrabutylammonium salts
Due to the increasing number of strains of drug-resistant bacteria, the development of new antibiotics has become increasingly important. The antibacterial properties of quaternary amines and their derivatives on both Gram-positive and Gram-negative bacteria are well known. However, an encompassing...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2009-09, Vol.19 (17), p.4984-4987 |
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| container_issue | 17 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Ingalsbe, Michelle L. Denis, Jeffrey D.St McGahan, Megan E. Steiner, Walter W. Priefer, Ronny |
| description | Due to the increasing number of strains of drug-resistant bacteria, the development of new antibiotics has become increasingly important. The antibacterial properties of quaternary amines and their derivatives on both Gram-positive and Gram-negative bacteria are well known. However, an encompassing study with specific emphasis on the role of the counter-anion has not been reported in the literature. By monitoring the Zone of Inhibition of various concentrations of tetrabutylammonium (TBA) salts, we observed that the counter anion plays a significant role in activity. We developed a novel method of reporting activity using zone of inhibition tests (ZI
MAX/K
ZI) and found it to be strongly correlated with the minimum inhibitory concentration (MIC). |
| doi_str_mv | 10.1016/j.bmcl.2009.07.066 |
| format | Article |
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MAX/K
ZI) and found it to be strongly correlated with the minimum inhibitory concentration (MIC).</description><subject>Anions - chemistry</subject><subject>Anions - pharmacology</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antimicrobial</subject><subject>Counter anion</subject><subject>Disk Diffusion Antimicrobial Tests</subject><subject>Quaternary Ammonium Compounds - chemistry</subject><subject>Quaternary Ammonium Compounds - pharmacology</subject><subject>Quaternary ammonium salts</subject><subject>Structure-Activity Relationship</subject><subject>Tetrabutylammonium</subject><subject>ZI MAX/K ZI</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UU1v1DAQtRCILoU_wAH5xqXZOrHjbCQuVfmqKOICUsXFmthj4VVsL7azYn8JfxenLacZvY_R6D1CXrds27JWXu63k9fztmNs3LJhy6R8QjatkKLhgvVPyYaNkjW7UdydkRc57xlrBRPiOTlrRynZKOSG_H2PR5zjwWMoNFoKNMQKUPxzSJizi-GC_ryhX6_uLr_U5YLamKjBgsm7AKXyq6v8QqrjEircQFhBtBZ1vRjuOQjFeadTnBzMFHRxR1dO904sCaalnGbwPga3eJphLvkleWZhzvjqcZ6THx8_fL_-3Nx--3RzfXXbYMt2sunB9sbwke-mrust4Gg1MjEAN6yDCYQRcpy00N2kpeQ7MD0KIbuus2AEt_ycvH24e0jx94K5KO-yxnmGgHHJauB8lMPQs6p886hcJo9GHZLzkE7qf5ZV8O5BgPXfo8OksnYYNBqXahbKRKdaptbq1F6t1am1OsUGVavj_wBOo472</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Ingalsbe, Michelle L.</creator><creator>Denis, Jeffrey D.St</creator><creator>McGahan, Megan E.</creator><creator>Steiner, Walter W.</creator><creator>Priefer, Ronny</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>Development of a novel expression, ZI MAX/K ZI, for determination of the counter-anion effect on the antimicrobial activity of tetrabutylammonium salts</title><author>Ingalsbe, Michelle L. ; Denis, Jeffrey D.St ; McGahan, Megan E. ; Steiner, Walter W. ; Priefer, Ronny</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e1086-5af5dd3938b225fae9fce047a3d02aba4d469bc4c2bc6638ad5e446222fad43f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Anions - chemistry</topic><topic>Anions - pharmacology</topic><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antimicrobial</topic><topic>Counter anion</topic><topic>Disk Diffusion Antimicrobial Tests</topic><topic>Quaternary Ammonium Compounds - chemistry</topic><topic>Quaternary Ammonium Compounds - pharmacology</topic><topic>Quaternary ammonium salts</topic><topic>Structure-Activity Relationship</topic><topic>Tetrabutylammonium</topic><topic>ZI MAX/K ZI</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ingalsbe, Michelle L.</creatorcontrib><creatorcontrib>Denis, Jeffrey D.St</creatorcontrib><creatorcontrib>McGahan, Megan E.</creatorcontrib><creatorcontrib>Steiner, Walter W.</creatorcontrib><creatorcontrib>Priefer, Ronny</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ingalsbe, Michelle L.</au><au>Denis, Jeffrey D.St</au><au>McGahan, Megan E.</au><au>Steiner, Walter W.</au><au>Priefer, Ronny</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of a novel expression, ZI MAX/K ZI, for determination of the counter-anion effect on the antimicrobial activity of tetrabutylammonium salts</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>19</volume><issue>17</issue><spage>4984</spage><epage>4987</epage><pages>4984-4987</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>Due to the increasing number of strains of drug-resistant bacteria, the development of new antibiotics has become increasingly important. The antibacterial properties of quaternary amines and their derivatives on both Gram-positive and Gram-negative bacteria are well known. However, an encompassing study with specific emphasis on the role of the counter-anion has not been reported in the literature. By monitoring the Zone of Inhibition of various concentrations of tetrabutylammonium (TBA) salts, we observed that the counter anion plays a significant role in activity. We developed a novel method of reporting activity using zone of inhibition tests (ZI
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| ispartof | Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.4984-4987 |
| issn | 0960-894X 1464-3405 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Anions - chemistry Anions - pharmacology Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antimicrobial Counter anion Disk Diffusion Antimicrobial Tests Quaternary Ammonium Compounds - chemistry Quaternary Ammonium Compounds - pharmacology Quaternary ammonium salts Structure-Activity Relationship Tetrabutylammonium ZI MAX/K ZI |
| title | Development of a novel expression, ZI MAX/K ZI, for determination of the counter-anion effect on the antimicrobial activity of tetrabutylammonium salts |
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