Improving d-mannitol productivity of Escherichia coli: impact of NAD, CO2 and expression of a putative sugar permease from Leuconostoc pseudomesenteroides

The highly productive whole-cell biotransformation of D-fructose to D-mannitol with recombinant, resting cells of Escherichia coli BL21(DE3) requires the combined expression of mdh, fdh and glf which encode mannitol and formate dehydrogenases and a sugar facilitator, respectively. However, long-term...

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Veröffentlicht in:	Metabolic engineering 2009-05, Vol.11 (3), p.178-183
Hauptverfasser:	Heuser, Florian, Marin, Kay, Kaup, Björn, Bringer, Stephanie, Sahm, Hermann
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - genetics Bacterial Proteins - metabolism Biotransformation Carbon Dioxide - physiology Escherichia coli - genetics Escherichia coli - metabolism Formates - metabolism Leuconostoc - genetics Leuconostoc - metabolism Mannitol - metabolism Membrane Transport Proteins - metabolism NAD - physiology
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