Lower frequency of the 5/5 homozygous CNDP1 genotype in South Asian Surinamese
Abstract We investigated the frequency of the 5/5 homozygous CNDP1 (carnosinase) genotype, which was found to be associated with a reduced risk of developing diabetic nephropathy, in three ethnic groups in The Netherlands. Particularly interesting were the South Asian Surinamese, who have a high pre...
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| Veröffentlicht in: | Diabetes research and clinical practice 2009-09, Vol.85 (3), p.272-278 |
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| creator | Mooyaart, A.L van Valkengoed, I.G.M Shaw, P.K. Chandie Peters, V Baelde, H.J Rabelink, T.J Bruijn, J.A Stronks, K de Heer, E |
| description | Abstract We investigated the frequency of the 5/5 homozygous CNDP1 (carnosinase) genotype, which was found to be associated with a reduced risk of developing diabetic nephropathy, in three ethnic groups in The Netherlands. Particularly interesting were the South Asian Surinamese, who have a high prevalence of diabetic nephropathy. Furthermore, we investigated the association between this gene and carnosinase activity in South Asian Surinamese and whether carnosinase was expressed in the kidney. We genotyped 290 South Asian Surinamese, 532 African Surinamese, and 472 White Dutch in a cross-sectional population study. Furthermore, an independent cohort of South Asian Surinamese was genotyped. In this population, carnosinase activity was measured in serum. Immunostaining and in situ hybridization for CNDP1 were performed on kidney tissue. Both South Asian populations had lower frequencies of the 5/5 homozygous genotype than African Surinamese and White Dutch (23.0%, 27.2%, 38.2%, and 41.3%, respectively; chi-square, p < 0.001). This genotype showed a lower carnosinase activity in South Asian Surinamese (Wilcoxon rank-sum, p = 0.03). CNDP1 was expressed in the kidney. South Asian Surinamese have a lower frequency of the 5/5 homozygous genotype, which was associated with lower carnosinase activity. Our study provides an indication that South Asian Surinamese are genetically at risk for developing diabetic nephropathy. |
| doi_str_mv | 10.1016/j.diabres.2009.06.001 |
| format | Article |
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Chandie ; Peters, V ; Baelde, H.J ; Rabelink, T.J ; Bruijn, J.A ; Stronks, K ; de Heer, E</creator><creatorcontrib>Mooyaart, A.L ; van Valkengoed, I.G.M ; Shaw, P.K. Chandie ; Peters, V ; Baelde, H.J ; Rabelink, T.J ; Bruijn, J.A ; Stronks, K ; de Heer, E</creatorcontrib><description>Abstract We investigated the frequency of the 5/5 homozygous CNDP1 (carnosinase) genotype, which was found to be associated with a reduced risk of developing diabetic nephropathy, in three ethnic groups in The Netherlands. Particularly interesting were the South Asian Surinamese, who have a high prevalence of diabetic nephropathy. Furthermore, we investigated the association between this gene and carnosinase activity in South Asian Surinamese and whether carnosinase was expressed in the kidney. We genotyped 290 South Asian Surinamese, 532 African Surinamese, and 472 White Dutch in a cross-sectional population study. Furthermore, an independent cohort of South Asian Surinamese was genotyped. In this population, carnosinase activity was measured in serum. Immunostaining and in situ hybridization for CNDP1 were performed on kidney tissue. Both South Asian populations had lower frequencies of the 5/5 homozygous genotype than African Surinamese and White Dutch (23.0%, 27.2%, 38.2%, and 41.3%, respectively; chi-square, p < 0.001). This genotype showed a lower carnosinase activity in South Asian Surinamese (Wilcoxon rank-sum, p = 0.03). CNDP1 was expressed in the kidney. South Asian Surinamese have a lower frequency of the 5/5 homozygous genotype, which was associated with lower carnosinase activity. Our study provides an indication that South Asian Surinamese are genetically at risk for developing diabetic nephropathy.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2009.06.001</identifier><identifier>PMID: 19577318</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Asian Continental Ancestry Group - genetics ; Cadaver ; Carnosinase ; CNDP1 ; Diabetic Nephropathies - epidemiology ; Diabetic Nephropathies - genetics ; Diabetic nephropathy ; Dipeptidases - blood ; Dipeptidases - genetics ; DNA Primers ; Endocrinology & Metabolism ; Exons ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Homozygote ; Humans ; Kidney - physiology ; Kidney - physiopathology ; Polymorphism ; Risk Factors ; RNA - genetics ; South Asian Surinamese ; Suriname - epidemiology ; Trinucleotide Repeats</subject><ispartof>Diabetes research and clinical practice, 2009-09, Vol.85 (3), p.272-278</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2009 Elsevier Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-35ab55cf20d7d6203974ef2931ae8a147197eb0c369bdaa7a83d0884d0dd31f93</citedby><cites>FETCH-LOGICAL-c485t-35ab55cf20d7d6203974ef2931ae8a147197eb0c369bdaa7a83d0884d0dd31f93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168822709002484$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19577318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mooyaart, A.L</creatorcontrib><creatorcontrib>van Valkengoed, I.G.M</creatorcontrib><creatorcontrib>Shaw, P.K. Chandie</creatorcontrib><creatorcontrib>Peters, V</creatorcontrib><creatorcontrib>Baelde, H.J</creatorcontrib><creatorcontrib>Rabelink, T.J</creatorcontrib><creatorcontrib>Bruijn, J.A</creatorcontrib><creatorcontrib>Stronks, K</creatorcontrib><creatorcontrib>de Heer, E</creatorcontrib><title>Lower frequency of the 5/5 homozygous CNDP1 genotype in South Asian Surinamese</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>Abstract We investigated the frequency of the 5/5 homozygous CNDP1 (carnosinase) genotype, which was found to be associated with a reduced risk of developing diabetic nephropathy, in three ethnic groups in The Netherlands. Particularly interesting were the South Asian Surinamese, who have a high prevalence of diabetic nephropathy. Furthermore, we investigated the association between this gene and carnosinase activity in South Asian Surinamese and whether carnosinase was expressed in the kidney. We genotyped 290 South Asian Surinamese, 532 African Surinamese, and 472 White Dutch in a cross-sectional population study. Furthermore, an independent cohort of South Asian Surinamese was genotyped. In this population, carnosinase activity was measured in serum. Immunostaining and in situ hybridization for CNDP1 were performed on kidney tissue. Both South Asian populations had lower frequencies of the 5/5 homozygous genotype than African Surinamese and White Dutch (23.0%, 27.2%, 38.2%, and 41.3%, respectively; chi-square, p < 0.001). This genotype showed a lower carnosinase activity in South Asian Surinamese (Wilcoxon rank-sum, p = 0.03). CNDP1 was expressed in the kidney. South Asian Surinamese have a lower frequency of the 5/5 homozygous genotype, which was associated with lower carnosinase activity. Our study provides an indication that South Asian Surinamese are genetically at risk for developing diabetic nephropathy.</description><subject>Asian Continental Ancestry Group - genetics</subject><subject>Cadaver</subject><subject>Carnosinase</subject><subject>CNDP1</subject><subject>Diabetic Nephropathies - epidemiology</subject><subject>Diabetic Nephropathies - genetics</subject><subject>Diabetic nephropathy</subject><subject>Dipeptidases - blood</subject><subject>Dipeptidases - genetics</subject><subject>DNA Primers</subject><subject>Endocrinology & Metabolism</subject><subject>Exons</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Kidney - physiology</subject><subject>Kidney - physiopathology</subject><subject>Polymorphism</subject><subject>Risk Factors</subject><subject>RNA - genetics</subject><subject>South Asian Surinamese</subject><subject>Suriname - epidemiology</subject><subject>Trinucleotide Repeats</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P0zAQQC0EYrsLPwHkG6dmx3ES2xfQqsCCVC1IC2fLsSdblyQudgIKvx6XVkLiwmnm8ObrDSEvGBQMWHO9L5w3bcRUlACqgKYAYI_IiklRrmVZisdklTn5J78glyntAaDhVf2UXDBVC8GZXJG7bfiJkXYRv8842oWGjk47pPV1TXdhCL-WhzAnurl7-5nRBxzDtByQ-pHeh3na0ZvkTc7n6EczYMJn5Eln-oTPz_GKfH3_7svmw3r76fbj5ma7tpWspzWvTVvXtivBCdeUwJWosCsVZwalYZVgSmALljeqdcYII7kDKSsHznHWKX5FXp36HmLIi6dJDz5Z7HszYt5XC85V0yioM1mfSBtDShE7fYh-MHHRDPTRpN7rs0l9NKmh0dlkrnt5njC3A7q_VWd1GXhzAjDf-cNj1Mn6rBCdj2gn7YL_74jX_3SwvR-9Nf03XDDtwxzHLFEznUoN-v74zuM3QQGUlaz4b5eKmuQ</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Mooyaart, A.L</creator><creator>van Valkengoed, I.G.M</creator><creator>Shaw, P.K. Chandie</creator><creator>Peters, V</creator><creator>Baelde, H.J</creator><creator>Rabelink, T.J</creator><creator>Bruijn, J.A</creator><creator>Stronks, K</creator><creator>de Heer, E</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>Lower frequency of the 5/5 homozygous CNDP1 genotype in South Asian Surinamese</title><author>Mooyaart, A.L ; van Valkengoed, I.G.M ; Shaw, P.K. Chandie ; Peters, V ; Baelde, H.J ; Rabelink, T.J ; Bruijn, J.A ; Stronks, K ; de Heer, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-35ab55cf20d7d6203974ef2931ae8a147197eb0c369bdaa7a83d0884d0dd31f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Asian Continental Ancestry Group - genetics</topic><topic>Cadaver</topic><topic>Carnosinase</topic><topic>CNDP1</topic><topic>Diabetic Nephropathies - epidemiology</topic><topic>Diabetic Nephropathies - genetics</topic><topic>Diabetic nephropathy</topic><topic>Dipeptidases - blood</topic><topic>Dipeptidases - genetics</topic><topic>DNA Primers</topic><topic>Endocrinology & Metabolism</topic><topic>Exons</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Homozygote</topic><topic>Humans</topic><topic>Kidney - physiology</topic><topic>Kidney - physiopathology</topic><topic>Polymorphism</topic><topic>Risk Factors</topic><topic>RNA - genetics</topic><topic>South Asian Surinamese</topic><topic>Suriname - epidemiology</topic><topic>Trinucleotide Repeats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mooyaart, A.L</creatorcontrib><creatorcontrib>van Valkengoed, I.G.M</creatorcontrib><creatorcontrib>Shaw, P.K. Chandie</creatorcontrib><creatorcontrib>Peters, V</creatorcontrib><creatorcontrib>Baelde, H.J</creatorcontrib><creatorcontrib>Rabelink, T.J</creatorcontrib><creatorcontrib>Bruijn, J.A</creatorcontrib><creatorcontrib>Stronks, K</creatorcontrib><creatorcontrib>de Heer, E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mooyaart, A.L</au><au>van Valkengoed, I.G.M</au><au>Shaw, P.K. Chandie</au><au>Peters, V</au><au>Baelde, H.J</au><au>Rabelink, T.J</au><au>Bruijn, J.A</au><au>Stronks, K</au><au>de Heer, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lower frequency of the 5/5 homozygous CNDP1 genotype in South Asian Surinamese</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>85</volume><issue>3</issue><spage>272</spage><epage>278</epage><pages>272-278</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>Abstract We investigated the frequency of the 5/5 homozygous CNDP1 (carnosinase) genotype, which was found to be associated with a reduced risk of developing diabetic nephropathy, in three ethnic groups in The Netherlands. Particularly interesting were the South Asian Surinamese, who have a high prevalence of diabetic nephropathy. Furthermore, we investigated the association between this gene and carnosinase activity in South Asian Surinamese and whether carnosinase was expressed in the kidney. We genotyped 290 South Asian Surinamese, 532 African Surinamese, and 472 White Dutch in a cross-sectional population study. Furthermore, an independent cohort of South Asian Surinamese was genotyped. In this population, carnosinase activity was measured in serum. Immunostaining and in situ hybridization for CNDP1 were performed on kidney tissue. Both South Asian populations had lower frequencies of the 5/5 homozygous genotype than African Surinamese and White Dutch (23.0%, 27.2%, 38.2%, and 41.3%, respectively; chi-square, p < 0.001). This genotype showed a lower carnosinase activity in South Asian Surinamese (Wilcoxon rank-sum, p = 0.03). CNDP1 was expressed in the kidney. South Asian Surinamese have a lower frequency of the 5/5 homozygous genotype, which was associated with lower carnosinase activity. Our study provides an indication that South Asian Surinamese are genetically at risk for developing diabetic nephropathy.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>19577318</pmid><doi>10.1016/j.diabres.2009.06.001</doi><tpages>7</tpages></addata></record> |
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| ispartof | Diabetes research and clinical practice, 2009-09, Vol.85 (3), p.272-278 |
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| subjects | Asian Continental Ancestry Group - genetics Cadaver Carnosinase CNDP1 Diabetic Nephropathies - epidemiology Diabetic Nephropathies - genetics Diabetic nephropathy Dipeptidases - blood Dipeptidases - genetics DNA Primers Endocrinology & Metabolism Exons Gene Frequency Genetic Predisposition to Disease Genotype Homozygote Humans Kidney - physiology Kidney - physiopathology Polymorphism Risk Factors RNA - genetics South Asian Surinamese Suriname - epidemiology Trinucleotide Repeats |
| title | Lower frequency of the 5/5 homozygous CNDP1 genotype in South Asian Surinamese |
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