Neopterin as a prognostic biomarker in intensive care unit patients
Abstract Purpose The present study was undertaken to evaluate urinary neopterin in intensive care unit patients. Materials and Methods Urinary neopterin levels were determined in systemic inflammatory response syndrome (n = 10), sepsis (n = 18), septic shock (n = 9), and multiple organ dysfunction s...
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| Veröffentlicht in: | Journal of critical care 2009-09, Vol.24 (3), p.318-321 |
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| creator | Baydar, Terken Yuksel, Osman Sahin, Tolga Tevfik Dikmen, Kursat Girgin, Gozde Sipahi, Hande Kurukahvecioglu, Osman Bostanci, Hasan Sare, Mustafa |
| description | Abstract Purpose The present study was undertaken to evaluate urinary neopterin in intensive care unit patients. Materials and Methods Urinary neopterin levels were determined in systemic inflammatory response syndrome (n = 10), sepsis (n = 18), septic shock (n = 9), and multiple organ dysfunction syndrome (n = 5). It was tested whether neopterin is a differential parameter among the patient groups. Furthermore, the results were also evaluated by comparing with a healthy control group (n = 30), and the relationship between neopterin and mortality or Acute Physiology and Chronic Health Evaluation II scores were investigated. Results Neopterin levels of the control group and patients were detected as 111 ± 11 and 3850 ± 1081 μ mol/mol creatinine, respectively ( P < .05). It was significantly increased in the sepsis and septic shock groups compared to the systemic inflammatory response syndrome group ( P < .05). Neopterin levels were significantly higher in the patients with mortality and lower Acute Physiology and Chronic Health Evaluation II scores. Conclusion This study showed that monitoring of urinary neopterin profile can be used in intensive care units to show the degree and prognosis of the disease. |
| doi_str_mv | 10.1016/j.jcrc.2008.06.013 |
| format | Article |
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Materials and Methods Urinary neopterin levels were determined in systemic inflammatory response syndrome (n = 10), sepsis (n = 18), septic shock (n = 9), and multiple organ dysfunction syndrome (n = 5). It was tested whether neopterin is a differential parameter among the patient groups. Furthermore, the results were also evaluated by comparing with a healthy control group (n = 30), and the relationship between neopterin and mortality or Acute Physiology and Chronic Health Evaluation II scores were investigated. Results Neopterin levels of the control group and patients were detected as 111 ± 11 and 3850 ± 1081 μ mol/mol creatinine, respectively ( P < .05). It was significantly increased in the sepsis and septic shock groups compared to the systemic inflammatory response syndrome group ( P < .05). Neopterin levels were significantly higher in the patients with mortality and lower Acute Physiology and Chronic Health Evaluation II scores. Conclusion This study showed that monitoring of urinary neopterin profile can be used in intensive care units to show the degree and prognosis of the disease.</description><identifier>ISSN: 0883-9441</identifier><identifier>EISSN: 1557-8615</identifier><identifier>DOI: 10.1016/j.jcrc.2008.06.013</identifier><identifier>PMID: 19327301</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; APACHE ; Bacterial infections ; Biomarkers - urine ; Critical Care ; Female ; Humans ; Immune system ; Intensive Care Units ; Male ; Middle Aged ; MODS ; Mortality ; Multiple Organ Failure - diagnosis ; Multiple Organ Failure - mortality ; Multiple Organ Failure - urine ; Neopterin ; Neopterin - urine ; Prognosis ; Sepsis ; Sepsis - diagnosis ; Sepsis - mortality ; Sepsis - urine ; Septic shock ; SIRS ; Systemic Inflammatory Response Syndrome - diagnosis ; Systemic Inflammatory Response Syndrome - mortality ; Systemic Inflammatory Response Syndrome - urine ; Viral infections</subject><ispartof>Journal of critical care, 2009-09, Vol.24 (3), p.318-321</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-7af1ba49f84583bb037f03ffe69371dbf3ad6cc761b2625f911f99aeb3d5728f3</citedby><cites>FETCH-LOGICAL-c504t-7af1ba49f84583bb037f03ffe69371dbf3ad6cc761b2625f911f99aeb3d5728f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1033238002?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978,64366,64368,64370,72220</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19327301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baydar, Terken</creatorcontrib><creatorcontrib>Yuksel, Osman</creatorcontrib><creatorcontrib>Sahin, Tolga Tevfik</creatorcontrib><creatorcontrib>Dikmen, Kursat</creatorcontrib><creatorcontrib>Girgin, Gozde</creatorcontrib><creatorcontrib>Sipahi, Hande</creatorcontrib><creatorcontrib>Kurukahvecioglu, Osman</creatorcontrib><creatorcontrib>Bostanci, Hasan</creatorcontrib><creatorcontrib>Sare, Mustafa</creatorcontrib><title>Neopterin as a prognostic biomarker in intensive care unit patients</title><title>Journal of critical care</title><addtitle>J Crit Care</addtitle><description>Abstract Purpose The present study was undertaken to evaluate urinary neopterin in intensive care unit patients. Materials and Methods Urinary neopterin levels were determined in systemic inflammatory response syndrome (n = 10), sepsis (n = 18), septic shock (n = 9), and multiple organ dysfunction syndrome (n = 5). It was tested whether neopterin is a differential parameter among the patient groups. Furthermore, the results were also evaluated by comparing with a healthy control group (n = 30), and the relationship between neopterin and mortality or Acute Physiology and Chronic Health Evaluation II scores were investigated. Results Neopterin levels of the control group and patients were detected as 111 ± 11 and 3850 ± 1081 μ mol/mol creatinine, respectively ( P < .05). It was significantly increased in the sepsis and septic shock groups compared to the systemic inflammatory response syndrome group ( P < .05). Neopterin levels were significantly higher in the patients with mortality and lower Acute Physiology and Chronic Health Evaluation II scores. Conclusion This study showed that monitoring of urinary neopterin profile can be used in intensive care units to show the degree and prognosis of the disease.</description><subject>Adult</subject><subject>Aged</subject><subject>APACHE</subject><subject>Bacterial infections</subject><subject>Biomarkers - urine</subject><subject>Critical Care</subject><subject>Female</subject><subject>Humans</subject><subject>Immune system</subject><subject>Intensive Care Units</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MODS</subject><subject>Mortality</subject><subject>Multiple Organ Failure - diagnosis</subject><subject>Multiple Organ Failure - mortality</subject><subject>Multiple Organ Failure - urine</subject><subject>Neopterin</subject><subject>Neopterin - urine</subject><subject>Prognosis</subject><subject>Sepsis</subject><subject>Sepsis - diagnosis</subject><subject>Sepsis - mortality</subject><subject>Sepsis - urine</subject><subject>Septic shock</subject><subject>SIRS</subject><subject>Systemic Inflammatory Response Syndrome - diagnosis</subject><subject>Systemic Inflammatory Response Syndrome - mortality</subject><subject>Systemic Inflammatory Response Syndrome - urine</subject><subject>Viral infections</subject><issn>0883-9441</issn><issn>1557-8615</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kcGK1TAUhoMoznX0BVxIwYWr1pOkSVoQYbjoKAy6UNchTU8knd70mqQD8_am3AsDs5hVFvn-w_m_Q8hbCg0FKj9OzWSjbRhA14BsgPJnZEeFUHUnqXhOdtB1vO7bll6QVylNAFRxLl6SC9pzpjjQHdn_wOWYMfpQmVSZ6hiXv2FJ2dtq8MvBxFuMVfn0IWNI_g4rayJWa_C5OprsMeT0mrxwZk745vxekj9fv_zef6tvfl5_31_d1FZAm2tlHB1M27uuFR0fBuDKAXcOZc8VHQfHzSitVZIOTDLhekpd3xsc-CgU6xy_JB9Oc8uS_1ZMWR98sjjPJuCyJl3K9VJyBYV8_4icljWGspymwDnjHQArFDtRNi4pRXT6GH2pfF8gvRnWk94M682wBqmL4RJ6dx69DgccHyJnpQX4dAKwqLjzGHWyRZPF0Ue0WY-Lf3r-50dxO_vgrZlv8R7TQw-dmAb9a7vxdmIolagA4P8BN1ygiw</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Baydar, Terken</creator><creator>Yuksel, Osman</creator><creator>Sahin, Tolga Tevfik</creator><creator>Dikmen, Kursat</creator><creator>Girgin, Gozde</creator><creator>Sipahi, Hande</creator><creator>Kurukahvecioglu, Osman</creator><creator>Bostanci, Hasan</creator><creator>Sare, Mustafa</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K6X</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20090901</creationdate><title>Neopterin as a prognostic biomarker in intensive care unit patients</title><author>Baydar, Terken ; Yuksel, Osman ; Sahin, Tolga Tevfik ; Dikmen, Kursat ; Girgin, Gozde ; Sipahi, Hande ; Kurukahvecioglu, Osman ; Bostanci, Hasan ; Sare, Mustafa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-7af1ba49f84583bb037f03ffe69371dbf3ad6cc761b2625f911f99aeb3d5728f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>APACHE</topic><topic>Bacterial infections</topic><topic>Biomarkers - urine</topic><topic>Critical Care</topic><topic>Female</topic><topic>Humans</topic><topic>Immune system</topic><topic>Intensive Care Units</topic><topic>Male</topic><topic>Middle Aged</topic><topic>MODS</topic><topic>Mortality</topic><topic>Multiple Organ Failure - diagnosis</topic><topic>Multiple Organ Failure - mortality</topic><topic>Multiple Organ Failure - urine</topic><topic>Neopterin</topic><topic>Neopterin - urine</topic><topic>Prognosis</topic><topic>Sepsis</topic><topic>Sepsis - diagnosis</topic><topic>Sepsis - mortality</topic><topic>Sepsis - urine</topic><topic>Septic shock</topic><topic>SIRS</topic><topic>Systemic Inflammatory Response Syndrome - diagnosis</topic><topic>Systemic Inflammatory Response Syndrome - mortality</topic><topic>Systemic Inflammatory Response Syndrome - urine</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baydar, Terken</creatorcontrib><creatorcontrib>Yuksel, Osman</creatorcontrib><creatorcontrib>Sahin, Tolga Tevfik</creatorcontrib><creatorcontrib>Dikmen, Kursat</creatorcontrib><creatorcontrib>Girgin, Gozde</creatorcontrib><creatorcontrib>Sipahi, Hande</creatorcontrib><creatorcontrib>Kurukahvecioglu, Osman</creatorcontrib><creatorcontrib>Bostanci, Hasan</creatorcontrib><creatorcontrib>Sare, Mustafa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of critical care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baydar, Terken</au><au>Yuksel, Osman</au><au>Sahin, Tolga Tevfik</au><au>Dikmen, Kursat</au><au>Girgin, Gozde</au><au>Sipahi, Hande</au><au>Kurukahvecioglu, Osman</au><au>Bostanci, Hasan</au><au>Sare, Mustafa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neopterin as a prognostic biomarker in intensive care unit patients</atitle><jtitle>Journal of critical care</jtitle><addtitle>J Crit Care</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>24</volume><issue>3</issue><spage>318</spage><epage>321</epage><pages>318-321</pages><issn>0883-9441</issn><eissn>1557-8615</eissn><abstract>Abstract Purpose The present study was undertaken to evaluate urinary neopterin in intensive care unit patients. Materials and Methods Urinary neopterin levels were determined in systemic inflammatory response syndrome (n = 10), sepsis (n = 18), septic shock (n = 9), and multiple organ dysfunction syndrome (n = 5). It was tested whether neopterin is a differential parameter among the patient groups. Furthermore, the results were also evaluated by comparing with a healthy control group (n = 30), and the relationship between neopterin and mortality or Acute Physiology and Chronic Health Evaluation II scores were investigated. Results Neopterin levels of the control group and patients were detected as 111 ± 11 and 3850 ± 1081 μ mol/mol creatinine, respectively ( P < .05). It was significantly increased in the sepsis and septic shock groups compared to the systemic inflammatory response syndrome group ( P < .05). Neopterin levels were significantly higher in the patients with mortality and lower Acute Physiology and Chronic Health Evaluation II scores. Conclusion This study showed that monitoring of urinary neopterin profile can be used in intensive care units to show the degree and prognosis of the disease.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19327301</pmid><doi>10.1016/j.jcrc.2008.06.013</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Aged APACHE Bacterial infections Biomarkers - urine Critical Care Female Humans Immune system Intensive Care Units Male Middle Aged MODS Mortality Multiple Organ Failure - diagnosis Multiple Organ Failure - mortality Multiple Organ Failure - urine Neopterin Neopterin - urine Prognosis Sepsis Sepsis - diagnosis Sepsis - mortality Sepsis - urine Septic shock SIRS Systemic Inflammatory Response Syndrome - diagnosis Systemic Inflammatory Response Syndrome - mortality Systemic Inflammatory Response Syndrome - urine Viral infections |
| title | Neopterin as a prognostic biomarker in intensive care unit patients |
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