Mechanism of Free Radical Oxygenation of Polyunsaturated Fatty Acids by Cyclooxygenases

This review considers the chemistry of fatty acid autoxidation and its parallels to PG biosynthesis and lays out the case for the formation of substrate- and protein- derived free radicals during catalysis.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical reviews 2003-06, Vol.103 (6), p.2239-2304
Hauptverfasser:	Rouzer, Carol A, Marnett, Lawrence J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Catalysis Fatty acids Fatty Acids, Unsaturated - chemistry Fatty Acids, Unsaturated - metabolism Free Radicals - chemistry Free Radicals - metabolism Humans Models, Molecular Oxidation Oxidation-Reduction Prostaglandin-Endoperoxide Synthases - chemistry Prostaglandin-Endoperoxide Synthases - metabolism Protein Conformation Substrate Specificity
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Beschreibung
Zusammenfassung:	This review considers the chemistry of fatty acid autoxidation and its parallels to PG biosynthesis and lays out the case for the formation of substrate- and protein- derived free radicals during catalysis.
ISSN:	0009-2665 1520-6890
DOI:	10.1021/cr000068x