Studies towards the total synthesis of lycoposerramine A. Synthesis of a model for the tetracyclic core

Lycoposerramine A (1) is a pentacyclic alkaloid isolated in 2001 by Takayama and co-workers. A concise synthesis of a model compound 8 for the tetracyclic core of this natural product is described. Key steps include the desymmetrising free-radical cyclisation of compound 7 to give compound 18 and sp...

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Veröffentlicht in:	Organic & biomolecular chemistry 2009-01, Vol.7 (17), p.3455-3462
Hauptverfasser:	Elliott, Mark C, Paine, James S
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemical synthesis Biological Products - chemical synthesis Cyclization Free Radicals - chemistry Models, Molecular Oxadiazoles - chemical synthesis Spiro Compounds - chemistry
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