Subconjunctival gene delivery of the transcription factor GA-binding protein delays corneal neovascularization in a mouse model

Corneal neovascularization can reduce visual acuity. GA-binding protein (GABP) is a transcription factor that regulates the expression of target genes including vascular endothelial growth factor ( VEGF ) and roundabout4 ( Robo4 ), which participate in pathologic angiogenesis. We assessed whether in...

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Veröffentlicht in:	Gene therapy 2009-08, Vol.16 (8), p.973-981
Hauptverfasser:	Yoon, K C, Bae, J A, Park, H J, Im, S K, Oh, H J, Lin, X H, Kim, M Y, Lee, J H, Lee, S E, Ahn, K Y, Kim, K K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acuity Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Angiogenesis Animals Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Blood vessels Care and treatment Cell Biology Cornea Corneal Neovascularization - genetics Corneal Neovascularization - therapy Deoxyribonucleic acid Disease Models, Animal DNA DNA binding proteins Epithelial cells Epithelium Eye diseases Fundamental and applied biological sciences. Psychology GA-binding protein GA-Binding Protein Transcription Factor - genetics Gene Expression Gene Therapy Gene transfer Gene Transfer Techniques Genetic aspects Health aspects Health. Pharmaceutical industry Human Genetics Humans Industrial applications and implications. Economical aspects Injection Injections, Intraocular Injuries Medical sciences Mice Mice, Inbred C57BL Nanotechnology Neovascularization Nerve Tissue Proteins - metabolism original-article Physiological aspects Proteins Receptors, Immunologic - metabolism Time Factors Transcription factors Transfection Transfusions. Complications. Transfusion reactions. Cell and gene therapy Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascularization
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