Fenofibrate attenuates endothelial monocyte adhesion in chronic heart failure: an in vitro study

Background Inflammation is implicated in chronic heart failure (CHF). In this study, the potential inhibitory effect of peroxisome proliferator‐activated receptor‐α (PPARα) activator fenofibrate on monocyte adhesion in CHF patients was investigated in vitro. Materials and methods Isolated peripher...

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Veröffentlicht in:	European journal of clinical investigation 2009-09, Vol.39 (9), p.775-783
Hauptverfasser:	Huang, W. P., Yin, W. H., Chen, J. W., Jen, H. L., Young, M. S., Lin, S. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aorta Biological and medical sciences Blotting, Western Cardiology. Vascular system Cell Adhesion - drug effects Cell adhesion molecules Chronic Disease chronic heart failure Endothelial cells endothelial monocyte adhesion Female Fenofibrate Fenofibrate - pharmacology Gene expression General aspects Heart Heart diseases Heart Failure - pathology Heart failure, cardiogenic pulmonary edema, cardiac enlargement Humans Inflammation Inflammation - pathology intercellular adhesion molecule 1 Leukocytes (mononuclear) Male Medical sciences Middle Aged Monocytes Monocytes - physiology Peripheral blood mononuclear cells peroxisome proliferator-activated receptor Peroxisome proliferator-activated receptor-a Tumor necrosis factor-a vascular cell adhesion molecule 1 Vascular Cell Adhesion Molecule-1 - biosynthesis Vascular Cell Adhesion Molecule-1 - drug effects Vascular system
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