Determination of fenofibric acid in human plasma by ultra performance liquid chromatography-electrospray ionization mass spectrometry: application to a bioequivalence study

A rapid, specific and sensitive ultra‐performance liquid chromatography tandem mass spectrometry method was developed for the determination of fenofibric acid in human plasma. The method involves simple, one‐step liquid–liquid extraction procedure coupled with an Acquity UPLCTM BEH C18 column (50 ×...

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Veröffentlicht in:	Biomedical chromatography 2009-09, Vol.23 (9), p.922-928
Hauptverfasser:	Bhavesh, Dasandi, Shah, Sanjay, Shivprakash
Format:	Artikel
Sprache:	eng
Schlagworte:	acquity Calibration Chromatography, High Pressure Liquid - methods Drug Stability Fenofibrate - analogs & derivatives Fenofibrate - blood fenofibric acid human plasma Humans LC-MS/MS Least-Squares Analysis Linear Models Male mefenamic acid Mefenamic Acid - analysis Reproducibility of Results Sensitivity and Specificity Spectrometry, Mass, Electrospray Ionization - methods Therapeutic Equivalency UPLC
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