The effects of non-steroidal anti-inflammatory compounds on human myometrial contractility

Objective: To investigate the effects of inhibitors of COX-1 or COX-2 on myometrial prostaglandin synthesis and on spontaneous contractions in human myometrium. Methods: Cultured myometrial cells were incubated with SC 58560 (COX-1 selective inhibitor) or SC 58236 (COX-2 selective inhibitor), and th...

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Veröffentlicht in:	European journal of obstetrics & gynecology and reproductive biology 2003-07, Vol.109 (1), p.33-40
Hauptverfasser:	Sawdy, Robert J, Sullivan, Mark H.F, Bennett, Phillip R
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Cells, Cultured Cyclo-oxygenase-2 Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology Female Genital system. Mammary gland Humans Indomethacin - pharmacology Investigative techniques, diagnostic techniques (general aspects) Isoenzymes - antagonists & inhibitors Medical sciences Meloxicam Membrane Proteins Myometrium Myometrium - drug effects Myometrium - metabolism NSAID Organic Chemicals Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pregnancy Prostaglandin-Endoperoxide Synthases Prostaglandins Prostaglandins - biosynthesis Pyrazoles Sulfonamides - pharmacology Thiazines - pharmacology Thiazoles - pharmacology Uterine Contraction - drug effects
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