Studies on the location of catecholamine receptors in canine sympathetic ganglia
Receptors mediating catecholamine-induced inhibition were studied in cardiac ganglia of pentobarbital-anesthetized dogs. Using selective agonists and antagonists the presence of three receptor subtypes was verified: α 1- and α 2-adrenoceptors and dopamine D 2 receptors. Activation of α 1-adrenocepto...
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| Veröffentlicht in: | European journal of pharmacology 1992-12, Vol.224 (2), p.103-107 |
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| container_title | European journal of pharmacology |
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| creator | Horn, Patrick T. Kohli, Jai D. |
| description | Receptors mediating catecholamine-induced inhibition were studied in cardiac ganglia of pentobarbital-anesthetized dogs. Using selective agonists and antagonists the presence of three receptor subtypes was verified:
α
1- and
α
2-adrenoceptors and dopamine D
2 receptors. Activation of
α
1-adrenoceptors or dopamine D
2 receptors reduced the response to preganglionic nerve stimulation but not to direct stimulation of the nicotinic acetylcholine receptors of the principal ganglion cells: response to both types of stimulation were reduced by activation of ganglionic
α
2-adrenoceptors. These results suggested that two inhibitory systems were present in canine sympathetic ganglia and mediated the effects of exogenous catecholamines. One system involved
α
1-adrenoceptors and dopamine D
2 receptors located proximal to the synapse of the pre- and postganglionic neurons and the other involved
α
2-adrenoceptors located distal to the intraganglionic synapse. |
| doi_str_mv | 10.1016/0014-2999(92)90793-4 |
| format | Article |
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α
1- and
α
2-adrenoceptors and dopamine D
2 receptors. Activation of
α
1-adrenoceptors or dopamine D
2 receptors reduced the response to preganglionic nerve stimulation but not to direct stimulation of the nicotinic acetylcholine receptors of the principal ganglion cells: response to both types of stimulation were reduced by activation of ganglionic
α
2-adrenoceptors. These results suggested that two inhibitory systems were present in canine sympathetic ganglia and mediated the effects of exogenous catecholamines. One system involved
α
1-adrenoceptors and dopamine D
2 receptors located proximal to the synapse of the pre- and postganglionic neurons and the other involved
α
2-adrenoceptors located distal to the intraganglionic synapse.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(92)90793-4</identifier><identifier>PMID: 1361445</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adrenergic alpha-Agonists - pharmacology ; Adrenergic alpha-Antagonists - pharmacology ; Animals ; Biological and medical sciences ; Catecholamine receptors ; Dimethylphenylpiperazinium Iodide - pharmacology ; Dogs ; Dopamine receptors ; Electric Stimulation ; Fundamental and applied biological sciences. Psychology ; Ganglia, Sympathetic - chemistry ; Ganglia, Sympathetic - drug effects ; Heart - innervation ; Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ ; Receptors, Adrenergic, alpha - analysis ; Receptors, Adrenergic, alpha - drug effects ; Receptors, Adrenergic, alpha - metabolism ; Receptors, Dopamine D2 - analysis ; Receptors, Dopamine D2 - drug effects ; Receptors, Dopamine D2 - metabolism ; Sympathetic ganglia ; Synaptic Transmission - physiology ; Vertebrates: nervous system and sense organs ; α-Adrenoceptors</subject><ispartof>European journal of pharmacology, 1992-12, Vol.224 (2), p.103-107</ispartof><rights>1992</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-3b9956e53036d3bd81ccfb381a01a5f565ac4453868517760f89e13d0e718ea3</citedby><cites>FETCH-LOGICAL-c483t-3b9956e53036d3bd81ccfb381a01a5f565ac4453868517760f89e13d0e718ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0014-2999(92)90793-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4472720$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1361445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horn, Patrick T.</creatorcontrib><creatorcontrib>Kohli, Jai D.</creatorcontrib><title>Studies on the location of catecholamine receptors in canine sympathetic ganglia</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Receptors mediating catecholamine-induced inhibition were studied in cardiac ganglia of pentobarbital-anesthetized dogs. Using selective agonists and antagonists the presence of three receptor subtypes was verified:
α
1- and
α
2-adrenoceptors and dopamine D
2 receptors. Activation of
α
1-adrenoceptors or dopamine D
2 receptors reduced the response to preganglionic nerve stimulation but not to direct stimulation of the nicotinic acetylcholine receptors of the principal ganglion cells: response to both types of stimulation were reduced by activation of ganglionic
α
2-adrenoceptors. These results suggested that two inhibitory systems were present in canine sympathetic ganglia and mediated the effects of exogenous catecholamines. One system involved
α
1-adrenoceptors and dopamine D
2 receptors located proximal to the synapse of the pre- and postganglionic neurons and the other involved
α
2-adrenoceptors located distal to the intraganglionic synapse.</description><subject>Adrenergic alpha-Agonists - pharmacology</subject><subject>Adrenergic alpha-Antagonists - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Catecholamine receptors</subject><subject>Dimethylphenylpiperazinium Iodide - pharmacology</subject><subject>Dogs</subject><subject>Dopamine receptors</subject><subject>Electric Stimulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganglia, Sympathetic - chemistry</subject><subject>Ganglia, Sympathetic - drug effects</subject><subject>Heart - innervation</subject><subject>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</subject><subject>Receptors, Adrenergic, alpha - analysis</subject><subject>Receptors, Adrenergic, alpha - drug effects</subject><subject>Receptors, Adrenergic, alpha - metabolism</subject><subject>Receptors, Dopamine D2 - analysis</subject><subject>Receptors, Dopamine D2 - drug effects</subject><subject>Receptors, Dopamine D2 - metabolism</subject><subject>Sympathetic ganglia</subject><subject>Synaptic Transmission - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>α-Adrenoceptors</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotVbfQGEWIroYTSb3jSDFGwgKdh_SzBmNzExqMhV8e1NbdKerXP7vXPgQOiT4nGAiLjAmrKy01qe6OtNYalqyLTQmSuoSS1Jto_EPsov2UnrDGHNd8REaESoIY3yMnp6HZe0hFaEvhlco2uDs4PMjNEW-gXsNre18D0UEB4shxFT4Pkf96i99dgubywbvihfbv7Te7qOdxrYJDjbnBM1urmfTu_Lh8fZ-evVQOqboUNK51lwAp5iKms5rRZxr5lQRi4nlDRfcurwgVUJxIqXAjdJAaI1BEgWWTtDJuu0ihvclpMF0PjloW9tDWCYjKdWiUupfkAhOpcqTJoitQRdDShEas4i-s_HTEGxWws3KplnZNLoy38INy2VHm_7LeQf1b9HacM6PN7lNzrZNtL3z6QdjTFaywhm7XGOQnX14iCY5D72D2mfxg6mD_3uPLxZem4E</recordid><startdate>19921202</startdate><enddate>19921202</enddate><creator>Horn, Patrick T.</creator><creator>Kohli, Jai D.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19921202</creationdate><title>Studies on the location of catecholamine receptors in canine sympathetic ganglia</title><author>Horn, Patrick T. ; Kohli, Jai D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-3b9956e53036d3bd81ccfb381a01a5f565ac4453868517760f89e13d0e718ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adrenergic alpha-Agonists - pharmacology</topic><topic>Adrenergic alpha-Antagonists - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Catecholamine receptors</topic><topic>Dimethylphenylpiperazinium Iodide - pharmacology</topic><topic>Dogs</topic><topic>Dopamine receptors</topic><topic>Electric Stimulation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglia, Sympathetic - chemistry</topic><topic>Ganglia, Sympathetic - drug effects</topic><topic>Heart - innervation</topic><topic>Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ</topic><topic>Receptors, Adrenergic, alpha - analysis</topic><topic>Receptors, Adrenergic, alpha - drug effects</topic><topic>Receptors, Adrenergic, alpha - metabolism</topic><topic>Receptors, Dopamine D2 - analysis</topic><topic>Receptors, Dopamine D2 - drug effects</topic><topic>Receptors, Dopamine D2 - metabolism</topic><topic>Sympathetic ganglia</topic><topic>Synaptic Transmission - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>α-Adrenoceptors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horn, Patrick T.</creatorcontrib><creatorcontrib>Kohli, Jai D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horn, Patrick T.</au><au>Kohli, Jai D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on the location of catecholamine receptors in canine sympathetic ganglia</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1992-12-02</date><risdate>1992</risdate><volume>224</volume><issue>2</issue><spage>103</spage><epage>107</epage><pages>103-107</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Receptors mediating catecholamine-induced inhibition were studied in cardiac ganglia of pentobarbital-anesthetized dogs. Using selective agonists and antagonists the presence of three receptor subtypes was verified:
α
1- and
α
2-adrenoceptors and dopamine D
2 receptors. Activation of
α
1-adrenoceptors or dopamine D
2 receptors reduced the response to preganglionic nerve stimulation but not to direct stimulation of the nicotinic acetylcholine receptors of the principal ganglion cells: response to both types of stimulation were reduced by activation of ganglionic
α
2-adrenoceptors. These results suggested that two inhibitory systems were present in canine sympathetic ganglia and mediated the effects of exogenous catecholamines. One system involved
α
1-adrenoceptors and dopamine D
2 receptors located proximal to the synapse of the pre- and postganglionic neurons and the other involved
α
2-adrenoceptors located distal to the intraganglionic synapse.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1361445</pmid><doi>10.1016/0014-2999(92)90793-4</doi><tpages>5</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1992-12, Vol.224 (2), p.103-107 |
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| language | eng |
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| subjects | Adrenergic alpha-Agonists - pharmacology Adrenergic alpha-Antagonists - pharmacology Animals Biological and medical sciences Catecholamine receptors Dimethylphenylpiperazinium Iodide - pharmacology Dogs Dopamine receptors Electric Stimulation Fundamental and applied biological sciences. Psychology Ganglia, Sympathetic - chemistry Ganglia, Sympathetic - drug effects Heart - innervation Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ Receptors, Adrenergic, alpha - analysis Receptors, Adrenergic, alpha - drug effects Receptors, Adrenergic, alpha - metabolism Receptors, Dopamine D2 - analysis Receptors, Dopamine D2 - drug effects Receptors, Dopamine D2 - metabolism Sympathetic ganglia Synaptic Transmission - physiology Vertebrates: nervous system and sense organs α-Adrenoceptors |
| title | Studies on the location of catecholamine receptors in canine sympathetic ganglia |
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