Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells

Apoptosis induced by most stimuli proceeds through the mitochondrial pathway. One such stimulus is nutrient deprivation. In this study we studied death induced by glucose deprivation in cells deficient in Bax and Bak. These cells cannot undergo mitochondrial outer membrane permeabilization (MOMP) du...

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Veröffentlicht in:	Cell death and differentiation 2010-08, Vol.17 (8), p.1335-1344
Hauptverfasser:	Caro-Maldonado, A, Tait, S W G, Ramírez-Peinado, S, Ricci, J-E, Fabregat, I, Green, D R, Muñoz-Pinedo, C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/319 631/45/607/1164 631/80/82/23 Apoptosis bcl-2 Homologous Antagonist-Killer Protein - deficiency bcl-2 Homologous Antagonist-Killer Protein - genetics bcl-2 Homologous Antagonist-Killer Protein - metabolism bcl-2-Associated X Protein - deficiency bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Biochemistry Biomedical and Life Sciences CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism Caspase 8 - genetics Caspase 8 - metabolism Caspase 9 - genetics Caspase 9 - metabolism Cell Biology Cell Cycle Analysis Cell death Cell Membrane Permeability - physiology Cytochrome Gene Knockdown Techniques Glucose Glucose - physiology HeLa Cells Humans Life Sciences Morphology original-paper Proteins Receptor-Interacting Protein Serine-Threonine Kinases - genetics Receptor-Interacting Protein Serine-Threonine Kinases - metabolism RNA Interference RNA, Small Interfering - metabolism Serpins - metabolism Stem Cells Viral Proteins - metabolism
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