Effect of ginsenoside Rb3 on myocardial injury and heart function impairment induced by isoproterenol in rats
The present study was designed to evaluate the effect of ginsenoside Rb3 on myocardial injury and heart function impairment induced by isoproterenol in rats. To induce myocardial ischemia, Sprague–Dawley rats were subcutaneously injected with isoproterenol (20 mg/kg). Cardiac marker enzymes and anti...
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| Veröffentlicht in: | European journal of pharmacology 2010-06, Vol.636 (1), p.121-125 |
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| description | The present study was designed to evaluate the effect of ginsenoside Rb3 on myocardial injury and heart function impairment induced by isoproterenol in rats. To induce myocardial ischemia, Sprague–Dawley rats were subcutaneously injected with isoproterenol (20
mg/kg). Cardiac marker enzymes and antioxidative parameters in left ventricles were measured. Hemodynamic parameters were monitored and recorded as well. Histopathological examination of left ventricles was performed. It was found that the levels of creatine kinase and lactate dehydrogenase in isoproterenol-treated rats were significantly increased. The rats administrated with isoproterenol showed the declines in left ventricular systolic pressure, positive and negative maximal values of the first derivative of left ventricular pressure, and an elevation of left ventricular end diastolic pressure. Isoproterenol enhanced the content of malondialdehyde and decreased the activities of superoxide dismutase, catalase in left ventricles. Administration of ginsenoside Rb3 significantly ameliorated myocardial injury and heart function impairment induced by isoproterenol. The cardioprotective effect of ginsenoside Rb3 was further confirmed by histopathological examination. Ginsenoside Rb3 also alleviated the increase of malondialdehyde content and decrease of superoxide dismutase and catalase activities in left ventricles. The results indicated that ginsenoside Rb3 possesses the effect against isoproterenol-induced myocardial injury and heart function impairment, and that the mechanism of pharmacological action was related to the antioxidant activity of ginsenoside Rb3 at least in part. |
| doi_str_mv | 10.1016/j.ejphar.2010.03.035 |
| format | Article |
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mg/kg). Cardiac marker enzymes and antioxidative parameters in left ventricles were measured. Hemodynamic parameters were monitored and recorded as well. Histopathological examination of left ventricles was performed. It was found that the levels of creatine kinase and lactate dehydrogenase in isoproterenol-treated rats were significantly increased. The rats administrated with isoproterenol showed the declines in left ventricular systolic pressure, positive and negative maximal values of the first derivative of left ventricular pressure, and an elevation of left ventricular end diastolic pressure. Isoproterenol enhanced the content of malondialdehyde and decreased the activities of superoxide dismutase, catalase in left ventricles. Administration of ginsenoside Rb3 significantly ameliorated myocardial injury and heart function impairment induced by isoproterenol. The cardioprotective effect of ginsenoside Rb3 was further confirmed by histopathological examination. Ginsenoside Rb3 also alleviated the increase of malondialdehyde content and decrease of superoxide dismutase and catalase activities in left ventricles. The results indicated that ginsenoside Rb3 possesses the effect against isoproterenol-induced myocardial injury and heart function impairment, and that the mechanism of pharmacological action was related to the antioxidant activity of ginsenoside Rb3 at least in part.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2010.03.035</identifier><identifier>PMID: 20371232</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiomyopathies ; Catalase - metabolism ; Coronary heart disease ; Creatine Kinase - metabolism ; Ginsenoside Rb3 ; Ginsenosides - pharmacology ; Heart ; Heart - drug effects ; Heart - physiopathology ; Heart function ; Heart Injuries - chemically induced ; Heart Injuries - metabolism ; Heart Injuries - pathology ; Heart Injuries - physiopathology ; Heart Ventricles - drug effects ; Heart Ventricles - pathology ; Isoproterenol ; Isoproterenol - pharmacology ; L-Lactate Dehydrogenase - metabolism ; Male ; Malondialdehyde - metabolism ; Medical sciences ; Myocardial ischemia ; Myocarditis. Cardiomyopathies ; Myocardium - enzymology ; Myocardium - metabolism ; Myocardium - pathology ; Pharmacology. Drug treatments ; Rats ; Rats, Sprague-Dawley ; Superoxide Dismutase - metabolism</subject><ispartof>European journal of pharmacology, 2010-06, Vol.636 (1), p.121-125</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>(c) 2010 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-40f08901ef18dce1a431305258b3accd4f3bd2b399a992b110298148ec6d9843</citedby><cites>FETCH-LOGICAL-c457t-40f08901ef18dce1a431305258b3accd4f3bd2b399a992b110298148ec6d9843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejphar.2010.03.035$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22798534$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20371232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Tian</creatorcontrib><creatorcontrib>Yu, Xiaofeng</creatorcontrib><creatorcontrib>Qu, Shaochun</creatorcontrib><creatorcontrib>Xu, Huali</creatorcontrib><creatorcontrib>Han, Bing</creatorcontrib><creatorcontrib>Sui, Dayuan</creatorcontrib><title>Effect of ginsenoside Rb3 on myocardial injury and heart function impairment induced by isoproterenol in rats</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The present study was designed to evaluate the effect of ginsenoside Rb3 on myocardial injury and heart function impairment induced by isoproterenol in rats. To induce myocardial ischemia, Sprague–Dawley rats were subcutaneously injected with isoproterenol (20
mg/kg). Cardiac marker enzymes and antioxidative parameters in left ventricles were measured. Hemodynamic parameters were monitored and recorded as well. Histopathological examination of left ventricles was performed. It was found that the levels of creatine kinase and lactate dehydrogenase in isoproterenol-treated rats were significantly increased. The rats administrated with isoproterenol showed the declines in left ventricular systolic pressure, positive and negative maximal values of the first derivative of left ventricular pressure, and an elevation of left ventricular end diastolic pressure. Isoproterenol enhanced the content of malondialdehyde and decreased the activities of superoxide dismutase, catalase in left ventricles. Administration of ginsenoside Rb3 significantly ameliorated myocardial injury and heart function impairment induced by isoproterenol. The cardioprotective effect of ginsenoside Rb3 was further confirmed by histopathological examination. Ginsenoside Rb3 also alleviated the increase of malondialdehyde content and decrease of superoxide dismutase and catalase activities in left ventricles. The results indicated that ginsenoside Rb3 possesses the effect against isoproterenol-induced myocardial injury and heart function impairment, and that the mechanism of pharmacological action was related to the antioxidant activity of ginsenoside Rb3 at least in part.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiomyopathies</subject><subject>Catalase - metabolism</subject><subject>Coronary heart disease</subject><subject>Creatine Kinase - metabolism</subject><subject>Ginsenoside Rb3</subject><subject>Ginsenosides - pharmacology</subject><subject>Heart</subject><subject>Heart - drug effects</subject><subject>Heart - physiopathology</subject><subject>Heart function</subject><subject>Heart Injuries - chemically induced</subject><subject>Heart Injuries - metabolism</subject><subject>Heart Injuries - pathology</subject><subject>Heart Injuries - physiopathology</subject><subject>Heart Ventricles - drug effects</subject><subject>Heart Ventricles - pathology</subject><subject>Isoproterenol</subject><subject>Isoproterenol - pharmacology</subject><subject>L-Lactate Dehydrogenase - metabolism</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Medical sciences</subject><subject>Myocardial ischemia</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Myocardium - enzymology</subject><subject>Myocardium - metabolism</subject><subject>Myocardium - pathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Superoxide Dismutase - metabolism</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEURoMoTjv6BiLZiKtqb5LKVLIRZBh_YECQ2YdUcuOkqErapErotzdNt7oTLgTC-W4-Tgh5zWDPgN28n_Y4HR5t2XNoVyDayCdkx9SgOxgYf0p2AKzvuNb6iryodQIAqbl8Tq44iEYIviPLXQjoVpoD_RFTxZRr9Ei_j4LmRJdjdrb4aGca07SVI7XJ00e0ZaVhS26NDYrLwcayYFob5DeHno5HGms-lLxiaStPaVrsWl-SZ8HOFV9dzmvy8Onu4fZLd__t89fbj_ed6-Wwdj0EUBoYBqa8Q2Z7wQRILtUorHO-D2L0fBRaW635yBhwrViv0N14rXpxTd6d17YGPzesq1lidTjPNmHeqhmE0FIrrRvZn0lXcq0FgzmUuNhyNAzMSbOZzFmzOWk2INrIFntzeWAbF_R_Q3-8NuDtBbDV2TkUm1ys_zg-aCXFqemHM4fNxq-IxVQXMTWHsbRvMT7H_zf5Dewynd4</recordid><startdate>20100625</startdate><enddate>20100625</enddate><creator>Wang, Tian</creator><creator>Yu, Xiaofeng</creator><creator>Qu, Shaochun</creator><creator>Xu, Huali</creator><creator>Han, Bing</creator><creator>Sui, Dayuan</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100625</creationdate><title>Effect of ginsenoside Rb3 on myocardial injury and heart function impairment induced by isoproterenol in rats</title><author>Wang, Tian ; Yu, Xiaofeng ; Qu, Shaochun ; Xu, Huali ; Han, Bing ; Sui, Dayuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-40f08901ef18dce1a431305258b3accd4f3bd2b399a992b110298148ec6d9843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cardiomyopathies</topic><topic>Catalase - metabolism</topic><topic>Coronary heart disease</topic><topic>Creatine Kinase - metabolism</topic><topic>Ginsenoside Rb3</topic><topic>Ginsenosides - pharmacology</topic><topic>Heart</topic><topic>Heart - drug effects</topic><topic>Heart - physiopathology</topic><topic>Heart function</topic><topic>Heart Injuries - chemically induced</topic><topic>Heart Injuries - metabolism</topic><topic>Heart Injuries - pathology</topic><topic>Heart Injuries - physiopathology</topic><topic>Heart Ventricles - drug effects</topic><topic>Heart Ventricles - pathology</topic><topic>Isoproterenol</topic><topic>Isoproterenol - pharmacology</topic><topic>L-Lactate Dehydrogenase - metabolism</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Medical sciences</topic><topic>Myocardial ischemia</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Myocardium - enzymology</topic><topic>Myocardium - metabolism</topic><topic>Myocardium - pathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Superoxide Dismutase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Tian</creatorcontrib><creatorcontrib>Yu, Xiaofeng</creatorcontrib><creatorcontrib>Qu, Shaochun</creatorcontrib><creatorcontrib>Xu, Huali</creatorcontrib><creatorcontrib>Han, Bing</creatorcontrib><creatorcontrib>Sui, Dayuan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Tian</au><au>Yu, Xiaofeng</au><au>Qu, Shaochun</au><au>Xu, Huali</au><au>Han, Bing</au><au>Sui, Dayuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of ginsenoside Rb3 on myocardial injury and heart function impairment induced by isoproterenol in rats</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2010-06-25</date><risdate>2010</risdate><volume>636</volume><issue>1</issue><spage>121</spage><epage>125</epage><pages>121-125</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The present study was designed to evaluate the effect of ginsenoside Rb3 on myocardial injury and heart function impairment induced by isoproterenol in rats. To induce myocardial ischemia, Sprague–Dawley rats were subcutaneously injected with isoproterenol (20
mg/kg). Cardiac marker enzymes and antioxidative parameters in left ventricles were measured. Hemodynamic parameters were monitored and recorded as well. Histopathological examination of left ventricles was performed. It was found that the levels of creatine kinase and lactate dehydrogenase in isoproterenol-treated rats were significantly increased. The rats administrated with isoproterenol showed the declines in left ventricular systolic pressure, positive and negative maximal values of the first derivative of left ventricular pressure, and an elevation of left ventricular end diastolic pressure. Isoproterenol enhanced the content of malondialdehyde and decreased the activities of superoxide dismutase, catalase in left ventricles. Administration of ginsenoside Rb3 significantly ameliorated myocardial injury and heart function impairment induced by isoproterenol. The cardioprotective effect of ginsenoside Rb3 was further confirmed by histopathological examination. Ginsenoside Rb3 also alleviated the increase of malondialdehyde content and decrease of superoxide dismutase and catalase activities in left ventricles. The results indicated that ginsenoside Rb3 possesses the effect against isoproterenol-induced myocardial injury and heart function impairment, and that the mechanism of pharmacological action was related to the antioxidant activity of ginsenoside Rb3 at least in part.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>20371232</pmid><doi>10.1016/j.ejphar.2010.03.035</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Cardiology. Vascular system Cardiomyopathies Catalase - metabolism Coronary heart disease Creatine Kinase - metabolism Ginsenoside Rb3 Ginsenosides - pharmacology Heart Heart - drug effects Heart - physiopathology Heart function Heart Injuries - chemically induced Heart Injuries - metabolism Heart Injuries - pathology Heart Injuries - physiopathology Heart Ventricles - drug effects Heart Ventricles - pathology Isoproterenol Isoproterenol - pharmacology L-Lactate Dehydrogenase - metabolism Male Malondialdehyde - metabolism Medical sciences Myocardial ischemia Myocarditis. Cardiomyopathies Myocardium - enzymology Myocardium - metabolism Myocardium - pathology Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Superoxide Dismutase - metabolism |
| title | Effect of ginsenoside Rb3 on myocardial injury and heart function impairment induced by isoproterenol in rats |
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