Protein oxidation biomarkers in plasma of type 2 diabetic patients
To evaluate oxidative stress and the extent of oxidation of plasma proteins in type 2 diabetic patients. Study was carried out on blood from 31 diabetic patients of both sexes (mean age = 58 ± 7; duration of diabetes 12 ± 5 years) and healthy age and sex matched normal subjects. Biomarkers of protei...
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| Veröffentlicht in: | Clinical biochemistry 2010-03, Vol.43 (4), p.508-511 |
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| creator | Pandey, Kanti Bhooshan Mishra, Neetu Rizvi, Syed Ibrahim |
| description | To evaluate oxidative stress and the extent of oxidation of plasma proteins in type 2 diabetic patients.
Study was carried out on blood from 31 diabetic patients of both sexes (mean age
=
58
±
7; duration of diabetes 12
±
5 years) and healthy age and sex matched normal subjects. Biomarkers of protein oxidation; plasma protein carbonyls (PCO), advanced oxidation protein products (AOPPs) and –SH group and free radical scavenging capacity of plasma was measured.
PCO and AOPPS levels were significantly (
P
<
0.005) higher in diabetic patients in comparison to healthy volunteers. Reduced free radical scavenging capacity (
P
<
0.001) and –SH group (
P
<
0.05) was observed in plasma of type 2 diabetic patients.
Our data suggest that diabetics are susceptible to protein oxidation. Oxidative modulation of proteins due to reduced radical scavenging activity of plasma patients may be one of the reasons of altered physiological processes in type 2 diabetic patients. |
| doi_str_mv | 10.1016/j.clinbiochem.2009.11.011 |
| format | Article |
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Study was carried out on blood from 31 diabetic patients of both sexes (mean age
=
58
±
7; duration of diabetes 12
±
5 years) and healthy age and sex matched normal subjects. Biomarkers of protein oxidation; plasma protein carbonyls (PCO), advanced oxidation protein products (AOPPs) and –SH group and free radical scavenging capacity of plasma was measured.
PCO and AOPPS levels were significantly (
P
<
0.005) higher in diabetic patients in comparison to healthy volunteers. Reduced free radical scavenging capacity (
P
<
0.001) and –SH group (
P
<
0.05) was observed in plasma of type 2 diabetic patients.
Our data suggest that diabetics are susceptible to protein oxidation. Oxidative modulation of proteins due to reduced radical scavenging activity of plasma patients may be one of the reasons of altered physiological processes in type 2 diabetic patients.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2009.11.011</identifier><identifier>PMID: 19941844</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Biological and medical sciences ; Biomarkers - blood ; Blood plasma ; Blood Proteins - metabolism ; Case-Control Studies ; Diabetes Mellitus, Type 2 - blood ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Free Radical Scavengers - metabolism ; Humans ; Male ; Medical sciences ; Middle Aged ; Oxidation-Reduction ; Oxidative stress ; Protein Carbonylation ; Protein oxidation ; Type2 diabetes</subject><ispartof>Clinical biochemistry, 2010-03, Vol.43 (4), p.508-511</ispartof><rights>2009 The Canadian Society of Clinical Chemists</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-4e9d2eead03c044fa0fbd40ca1064b5ec3c4715349ccfb44ac1380123e529d5f3</citedby><cites>FETCH-LOGICAL-c406t-4e9d2eead03c044fa0fbd40ca1064b5ec3c4715349ccfb44ac1380123e529d5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinbiochem.2009.11.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22585237$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19941844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pandey, Kanti Bhooshan</creatorcontrib><creatorcontrib>Mishra, Neetu</creatorcontrib><creatorcontrib>Rizvi, Syed Ibrahim</creatorcontrib><title>Protein oxidation biomarkers in plasma of type 2 diabetic patients</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>To evaluate oxidative stress and the extent of oxidation of plasma proteins in type 2 diabetic patients.
Study was carried out on blood from 31 diabetic patients of both sexes (mean age
=
58
±
7; duration of diabetes 12
±
5 years) and healthy age and sex matched normal subjects. Biomarkers of protein oxidation; plasma protein carbonyls (PCO), advanced oxidation protein products (AOPPs) and –SH group and free radical scavenging capacity of plasma was measured.
PCO and AOPPS levels were significantly (
P
<
0.005) higher in diabetic patients in comparison to healthy volunteers. Reduced free radical scavenging capacity (
P
<
0.001) and –SH group (
P
<
0.05) was observed in plasma of type 2 diabetic patients.
Our data suggest that diabetics are susceptible to protein oxidation. Oxidative modulation of proteins due to reduced radical scavenging activity of plasma patients may be one of the reasons of altered physiological processes in type 2 diabetic patients.</description><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood plasma</subject><subject>Blood Proteins - metabolism</subject><subject>Case-Control Studies</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Free Radical Scavengers - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Oxidation-Reduction</subject><subject>Oxidative stress</subject><subject>Protein Carbonylation</subject><subject>Protein oxidation</subject><subject>Type2 diabetes</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtP3DAURi0EguHxF6p0gbpK8LWdSbxsR21BQqKLdm051zeqhyQOdgbBv6_RjNouWVm2z318h7GPwCvgsL7ZVjj4qfMBf9NYCc51BVBxgCO2graRpdBSHrMVzz-lBsHP2HlK23wVql2fsjPQWkGr1Ip9-RHDQn4qwot3dvFhKnLf0cZHiqnI7_Ng02iL0BfL60yFKJy3HS0eiznjNC3pkp30dkh0dTgv2K9vX39ubsv7h-93m8_3JSq-XkpF2gki67hErlRved85xdECX6uuJpSoGqil0oh9p5RFkC0HIakW2tW9vGCf9n3nGJ52lBYz-oQ0DHaisEumkVLXTU6YSb0nMYaUIvVmjj5nejXAzZtBszX_GTRvBg2AyQZz7YfDlF03kvtXeVCWgesDYBPaoY92Qp_-ckLUbS1kk7nNnqPs5NlTNAmzLyTnI-FiXPDvWOcPyn2U3g</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Pandey, Kanti Bhooshan</creator><creator>Mishra, Neetu</creator><creator>Rizvi, Syed Ibrahim</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100301</creationdate><title>Protein oxidation biomarkers in plasma of type 2 diabetic patients</title><author>Pandey, Kanti Bhooshan ; Mishra, Neetu ; Rizvi, Syed Ibrahim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-4e9d2eead03c044fa0fbd40ca1064b5ec3c4715349ccfb44ac1380123e529d5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood plasma</topic><topic>Blood Proteins - metabolism</topic><topic>Case-Control Studies</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Free Radical Scavengers - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Oxidation-Reduction</topic><topic>Oxidative stress</topic><topic>Protein Carbonylation</topic><topic>Protein oxidation</topic><topic>Type2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pandey, Kanti Bhooshan</creatorcontrib><creatorcontrib>Mishra, Neetu</creatorcontrib><creatorcontrib>Rizvi, Syed Ibrahim</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pandey, Kanti Bhooshan</au><au>Mishra, Neetu</au><au>Rizvi, Syed Ibrahim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein oxidation biomarkers in plasma of type 2 diabetic patients</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>43</volume><issue>4</issue><spage>508</spage><epage>511</epage><pages>508-511</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>To evaluate oxidative stress and the extent of oxidation of plasma proteins in type 2 diabetic patients.
Study was carried out on blood from 31 diabetic patients of both sexes (mean age
=
58
±
7; duration of diabetes 12
±
5 years) and healthy age and sex matched normal subjects. Biomarkers of protein oxidation; plasma protein carbonyls (PCO), advanced oxidation protein products (AOPPs) and –SH group and free radical scavenging capacity of plasma was measured.
PCO and AOPPS levels were significantly (
P
<
0.005) higher in diabetic patients in comparison to healthy volunteers. Reduced free radical scavenging capacity (
P
<
0.001) and –SH group (
P
<
0.05) was observed in plasma of type 2 diabetic patients.
Our data suggest that diabetics are susceptible to protein oxidation. Oxidative modulation of proteins due to reduced radical scavenging activity of plasma patients may be one of the reasons of altered physiological processes in type 2 diabetic patients.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>19941844</pmid><doi>10.1016/j.clinbiochem.2009.11.011</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Clinical biochemistry, 2010-03, Vol.43 (4), p.508-511 |
| issn | 0009-9120 1873-2933 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Biomarkers - blood Blood plasma Blood Proteins - metabolism Case-Control Studies Diabetes Mellitus, Type 2 - blood Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Free Radical Scavengers - metabolism Humans Male Medical sciences Middle Aged Oxidation-Reduction Oxidative stress Protein Carbonylation Protein oxidation Type2 diabetes |
| title | Protein oxidation biomarkers in plasma of type 2 diabetic patients |
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