Antiandrogen-induced cell death in LNCaP human prostate cancer cells

Antiandrogens such as Casodex (Bicalutamide) are designed to treat advance stage prostate cancer by interfering with androgen receptor-mediated cell survival and by initiating cell death. Treatment of androgen sensitive, non-metastatic LNCaP human prostate cancer cells with 0-100 microM Casodex or 0...

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Veröffentlicht in:	Cell death and differentiation 2003-07, Vol.10 (7), p.761-771
Hauptverfasser:	Lee, E C Y, Zhan, P, Schallhom, R, Packman, K, Tenniswood, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - pharmacology Androgen Antagonists - therapeutic use Anilides - pharmacology bcl-2-Associated X Protein Carcinoma - drug therapy Carcinoma - metabolism Carcinoma - physiopathology Caspases - drug effects Caspases - metabolism Cell Adhesion - drug effects Cell Adhesion - physiology Cell death Cell Death - drug effects Cell Death - physiology Cell Nucleus - drug effects Cell Nucleus - metabolism Cell Survival - drug effects Cell Survival - physiology Cytochromes c - metabolism Humans Male Membrane Potentials - drug effects Membrane Potentials - physiology Mitochondria - drug effects Mitochondria - metabolism Nitriles Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Prostatic Neoplasms - physiopathology Proto-Oncogene Proteins - drug effects Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Tosyl Compounds Tumor Cells, Cultured Tumor Necrosis Factor-alpha - pharmacology
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