Mitochondrial Complex I Subunits Are Decreased in Murine Nonalcoholic Fatty Liver Disease: Implication of Peroxynitrite

We investigate the cause of the low activity of mitochondrial complex I found in ob/ob mice with nonalcoholic fatty liver disease. In mitochondrial proteins from ob/ob mice, we assessed complex I activity, fully assembled complex I, and its subunits, oxygen consumption, gene expression of complex I...

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Veröffentlicht in:	Journal of proteome research 2010-05, Vol.9 (5), p.2450-2459
Hauptverfasser:	García-Ruiz, Inmaculada, Fernández-Moreira, Daniel, Solís-Muñoz, Pablo, Rodríguez-Juan, Cristina, Díaz-Sanjuán, Teresa, Muñoz-Yagüe, Teresa, Solís-Herruzo, José A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA Damage DNA, Mitochondrial - metabolism Electron Transport Complex I - chemistry Electron Transport Complex I - drug effects Electron Transport Complex I - genetics Electron Transport Complex I - metabolism Fatty Liver - metabolism Fatty Liver - pathology Leptin - genetics Liver - chemistry Liver - drug effects Male Metalloporphyrins Mice Mice, Inbred C57BL Mice, Obese Mice, Transgenic Mitochondrial Membranes - metabolism Oxidative Stress Peroxynitrous Acid - pharmacology Repressor Proteins - metabolism
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