Metabolic cardiovascular disease risk factors and their clustering in subclinical hypothyroidism
Summary Objective A possible association between subclinical hypothyroidism and cardiovascular disease (CVD) has been reported. Monitoring of atomic‐bomb survivors for late effects of radiation exposure at the Radiation Effects Research Foundation has provided the opportunity to examine association...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2010-05, Vol.72 (5), p.689-695 |
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| creator | Ashizawa, Kiyoto Imaizumi, Misa Usa, Toshiro Tominaga, Tan Sera, Nobuko Hida, Ayumi Ejima, Eri Neriishi, Kazuo Soda, Midori Ichimaru, Shinichiro Nakashima, Eiji Fujiwara, Saeko Maeda, Renju Nagataki, Shigenobu Eguchi, Katsumi Akahoshi, Masazumi |
| description | Summary
Objective A possible association between subclinical hypothyroidism and cardiovascular disease (CVD) has been reported. Monitoring of atomic‐bomb survivors for late effects of radiation exposure at the Radiation Effects Research Foundation has provided the opportunity to examine associations between subclinical hypothyroidism and metabolic CVD risk factors. The objective of the study was to evaluate associations between subclinical hypothyroidism and metabolic CVD risk factors, and a cluster of these factors.
Design and participants This was a cross‐sectional study of 3549 subjects (mean age 70 years; 1221 men and 2328 women) between 2000 and 2003 comprising 306 subjects with subclinical hypothyroidism and 3243 control euthyroid subjects in Japan.
Measurements We investigated associations between subclinical hypothyroidism and metabolic CVD risk factors such as hypertension, diabetes mellitus, dyslipidaemia and hyperuricaemia, and a cluster of these factors.
Results Subclinical hypothyroidism was not significantly associated with either hypertension, diabetes mellitus or hyperuricaemia defined by taking into account the use of medications in both men and women, but in men it was associated with dyslipidaemia (P = 0·02). We observed a significantly increased odds ratio (OR) for the presence of three or more metabolic CVD risk factors in men with subclinical hypothyroidism after adjusting for age, body mass index (BMI), and smoking status [OR: 1·83, 95% confidence interval (CI): 1·13–2·94, P = 0·01]. The significant associations remained after an additional adjustment for atomic‐bomb radiation dose.
Conclusions There appears to be a significant increase in a cluster of metabolic CVD risk factors among people with subclinical hypothyroidism. |
| doi_str_mv | 10.1111/j.1365-2265.2009.03697.x |
| format | Article |
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Objective A possible association between subclinical hypothyroidism and cardiovascular disease (CVD) has been reported. Monitoring of atomic‐bomb survivors for late effects of radiation exposure at the Radiation Effects Research Foundation has provided the opportunity to examine associations between subclinical hypothyroidism and metabolic CVD risk factors. The objective of the study was to evaluate associations between subclinical hypothyroidism and metabolic CVD risk factors, and a cluster of these factors.
Design and participants This was a cross‐sectional study of 3549 subjects (mean age 70 years; 1221 men and 2328 women) between 2000 and 2003 comprising 306 subjects with subclinical hypothyroidism and 3243 control euthyroid subjects in Japan.
Measurements We investigated associations between subclinical hypothyroidism and metabolic CVD risk factors such as hypertension, diabetes mellitus, dyslipidaemia and hyperuricaemia, and a cluster of these factors.
Results Subclinical hypothyroidism was not significantly associated with either hypertension, diabetes mellitus or hyperuricaemia defined by taking into account the use of medications in both men and women, but in men it was associated with dyslipidaemia (P = 0·02). We observed a significantly increased odds ratio (OR) for the presence of three or more metabolic CVD risk factors in men with subclinical hypothyroidism after adjusting for age, body mass index (BMI), and smoking status [OR: 1·83, 95% confidence interval (CI): 1·13–2·94, P = 0·01]. The significant associations remained after an additional adjustment for atomic‐bomb radiation dose.
Conclusions There appears to be a significant increase in a cluster of metabolic CVD risk factors among people with subclinical hypothyroidism.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2009.03697.x</identifier><identifier>PMID: 20447067</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Biological and medical sciences ; Body Mass Index ; Cardiovascular Diseases - complications ; Chi-Square Distribution ; Cross-Sectional Studies ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Hypothyroidism - complications ; Hypothyroidism - pathology ; Male ; Medical sciences ; Metabolic Diseases - complications ; Middle Aged ; Multivariate Analysis ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Odds Ratio ; Radiation, Ionizing ; Regression Analysis ; Risk Factors ; Sex Factors ; Smoking ; Thyroid. Thyroid axis (diseases) ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2010-05, Vol.72 (5), p.689-695</ispartof><rights>2010 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4647-7b112d0400313e7f4612d7fb337dc89fc282363b69f5d81972a904f686f159aa3</citedby><cites>FETCH-LOGICAL-c4647-7b112d0400313e7f4612d7fb337dc89fc282363b69f5d81972a904f686f159aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2009.03697.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2009.03697.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22550490$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20447067$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ashizawa, Kiyoto</creatorcontrib><creatorcontrib>Imaizumi, Misa</creatorcontrib><creatorcontrib>Usa, Toshiro</creatorcontrib><creatorcontrib>Tominaga, Tan</creatorcontrib><creatorcontrib>Sera, Nobuko</creatorcontrib><creatorcontrib>Hida, Ayumi</creatorcontrib><creatorcontrib>Ejima, Eri</creatorcontrib><creatorcontrib>Neriishi, Kazuo</creatorcontrib><creatorcontrib>Soda, Midori</creatorcontrib><creatorcontrib>Ichimaru, Shinichiro</creatorcontrib><creatorcontrib>Nakashima, Eiji</creatorcontrib><creatorcontrib>Fujiwara, Saeko</creatorcontrib><creatorcontrib>Maeda, Renju</creatorcontrib><creatorcontrib>Nagataki, Shigenobu</creatorcontrib><creatorcontrib>Eguchi, Katsumi</creatorcontrib><creatorcontrib>Akahoshi, Masazumi</creatorcontrib><title>Metabolic cardiovascular disease risk factors and their clustering in subclinical hypothyroidism</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
Objective A possible association between subclinical hypothyroidism and cardiovascular disease (CVD) has been reported. Monitoring of atomic‐bomb survivors for late effects of radiation exposure at the Radiation Effects Research Foundation has provided the opportunity to examine associations between subclinical hypothyroidism and metabolic CVD risk factors. The objective of the study was to evaluate associations between subclinical hypothyroidism and metabolic CVD risk factors, and a cluster of these factors.
Design and participants This was a cross‐sectional study of 3549 subjects (mean age 70 years; 1221 men and 2328 women) between 2000 and 2003 comprising 306 subjects with subclinical hypothyroidism and 3243 control euthyroid subjects in Japan.
Measurements We investigated associations between subclinical hypothyroidism and metabolic CVD risk factors such as hypertension, diabetes mellitus, dyslipidaemia and hyperuricaemia, and a cluster of these factors.
Results Subclinical hypothyroidism was not significantly associated with either hypertension, diabetes mellitus or hyperuricaemia defined by taking into account the use of medications in both men and women, but in men it was associated with dyslipidaemia (P = 0·02). We observed a significantly increased odds ratio (OR) for the presence of three or more metabolic CVD risk factors in men with subclinical hypothyroidism after adjusting for age, body mass index (BMI), and smoking status [OR: 1·83, 95% confidence interval (CI): 1·13–2·94, P = 0·01]. The significant associations remained after an additional adjustment for atomic‐bomb radiation dose.
Conclusions There appears to be a significant increase in a cluster of metabolic CVD risk factors among people with subclinical hypothyroidism.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Cardiovascular Diseases - complications</subject><subject>Chi-Square Distribution</subject><subject>Cross-Sectional Studies</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hypothyroidism - complications</subject><subject>Hypothyroidism - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic Diseases - complications</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Odds Ratio</subject><subject>Radiation, Ionizing</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Smoking</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2O0zAUhS0EYsrAKyBLCLFKuPFvvGCBqmFAKmUDVGJjHMem7qRJsRNo3x6XliKxwhvb8neuj85BCFdQVnm93JQVFbwgRPCSAKgSqFCy3N9Ds8vDfTQDClCAEOwKPUppAwC8BvkQXRFgTIKQM_T1vRtNM3TBYmtiG4YfJtmpMxG3ITmTHI4h3WFv7DjEhE3f4nHtQsS2m9LoYui_4dDjNDW2C32wpsPrw24Y14c4hDxi-xg98KZL7sl5v0af3tx8nL8tFh9u381fLwrLBJOFbKqKtMAAaEWd9Ezkq_QNpbK1tfKW1IQK2gjleVtXShKjgHlRC19xZQy9Ri9Oc3dx-D65NOptSNZ1nendMCUtKVWcE1Jn8tk_5GaYYp_N6YozXtdMUJ6p-kTZOKQUnde7GLYmHnQF-liC3uhj1vqYtT6WoH-XoPdZ-vT8wdRsXXsR_kk9A8_PQA7bdD6a3ob0lyOcA1OQuVcn7mfo3OG_Dej5zfJ4yvripA-5qv1Fb-Kdzi4k16vlrf6sVl8WcrnSiv4CJb6xgA</recordid><startdate>201005</startdate><enddate>201005</enddate><creator>Ashizawa, Kiyoto</creator><creator>Imaizumi, Misa</creator><creator>Usa, Toshiro</creator><creator>Tominaga, Tan</creator><creator>Sera, Nobuko</creator><creator>Hida, Ayumi</creator><creator>Ejima, Eri</creator><creator>Neriishi, Kazuo</creator><creator>Soda, Midori</creator><creator>Ichimaru, Shinichiro</creator><creator>Nakashima, Eiji</creator><creator>Fujiwara, Saeko</creator><creator>Maeda, Renju</creator><creator>Nagataki, Shigenobu</creator><creator>Eguchi, Katsumi</creator><creator>Akahoshi, Masazumi</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201005</creationdate><title>Metabolic cardiovascular disease risk factors and their clustering in subclinical hypothyroidism</title><author>Ashizawa, Kiyoto ; Imaizumi, Misa ; Usa, Toshiro ; Tominaga, Tan ; Sera, Nobuko ; Hida, Ayumi ; Ejima, Eri ; Neriishi, Kazuo ; Soda, Midori ; Ichimaru, Shinichiro ; Nakashima, Eiji ; Fujiwara, Saeko ; Maeda, Renju ; Nagataki, Shigenobu ; Eguchi, Katsumi ; Akahoshi, Masazumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4647-7b112d0400313e7f4612d7fb337dc89fc282363b69f5d81972a904f686f159aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Cardiovascular Diseases - complications</topic><topic>Chi-Square Distribution</topic><topic>Cross-Sectional Studies</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hypothyroidism - complications</topic><topic>Hypothyroidism - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic Diseases - complications</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Odds Ratio</topic><topic>Radiation, Ionizing</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Smoking</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ashizawa, Kiyoto</creatorcontrib><creatorcontrib>Imaizumi, Misa</creatorcontrib><creatorcontrib>Usa, Toshiro</creatorcontrib><creatorcontrib>Tominaga, Tan</creatorcontrib><creatorcontrib>Sera, Nobuko</creatorcontrib><creatorcontrib>Hida, Ayumi</creatorcontrib><creatorcontrib>Ejima, Eri</creatorcontrib><creatorcontrib>Neriishi, Kazuo</creatorcontrib><creatorcontrib>Soda, Midori</creatorcontrib><creatorcontrib>Ichimaru, Shinichiro</creatorcontrib><creatorcontrib>Nakashima, Eiji</creatorcontrib><creatorcontrib>Fujiwara, Saeko</creatorcontrib><creatorcontrib>Maeda, Renju</creatorcontrib><creatorcontrib>Nagataki, Shigenobu</creatorcontrib><creatorcontrib>Eguchi, Katsumi</creatorcontrib><creatorcontrib>Akahoshi, Masazumi</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ashizawa, Kiyoto</au><au>Imaizumi, Misa</au><au>Usa, Toshiro</au><au>Tominaga, Tan</au><au>Sera, Nobuko</au><au>Hida, Ayumi</au><au>Ejima, Eri</au><au>Neriishi, Kazuo</au><au>Soda, Midori</au><au>Ichimaru, Shinichiro</au><au>Nakashima, Eiji</au><au>Fujiwara, Saeko</au><au>Maeda, Renju</au><au>Nagataki, Shigenobu</au><au>Eguchi, Katsumi</au><au>Akahoshi, Masazumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic cardiovascular disease risk factors and their clustering in subclinical hypothyroidism</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2010-05</date><risdate>2010</risdate><volume>72</volume><issue>5</issue><spage>689</spage><epage>695</epage><pages>689-695</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Objective A possible association between subclinical hypothyroidism and cardiovascular disease (CVD) has been reported. Monitoring of atomic‐bomb survivors for late effects of radiation exposure at the Radiation Effects Research Foundation has provided the opportunity to examine associations between subclinical hypothyroidism and metabolic CVD risk factors. The objective of the study was to evaluate associations between subclinical hypothyroidism and metabolic CVD risk factors, and a cluster of these factors.
Design and participants This was a cross‐sectional study of 3549 subjects (mean age 70 years; 1221 men and 2328 women) between 2000 and 2003 comprising 306 subjects with subclinical hypothyroidism and 3243 control euthyroid subjects in Japan.
Measurements We investigated associations between subclinical hypothyroidism and metabolic CVD risk factors such as hypertension, diabetes mellitus, dyslipidaemia and hyperuricaemia, and a cluster of these factors.
Results Subclinical hypothyroidism was not significantly associated with either hypertension, diabetes mellitus or hyperuricaemia defined by taking into account the use of medications in both men and women, but in men it was associated with dyslipidaemia (P = 0·02). We observed a significantly increased odds ratio (OR) for the presence of three or more metabolic CVD risk factors in men with subclinical hypothyroidism after adjusting for age, body mass index (BMI), and smoking status [OR: 1·83, 95% confidence interval (CI): 1·13–2·94, P = 0·01]. The significant associations remained after an additional adjustment for atomic‐bomb radiation dose.
Conclusions There appears to be a significant increase in a cluster of metabolic CVD risk factors among people with subclinical hypothyroidism.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20447067</pmid><doi>10.1111/j.1365-2265.2009.03697.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | Clinical endocrinology (Oxford), 2010-05, Vol.72 (5), p.689-695 |
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| language | eng |
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| subjects | Aged Biological and medical sciences Body Mass Index Cardiovascular Diseases - complications Chi-Square Distribution Cross-Sectional Studies Endocrinopathies Female Fundamental and applied biological sciences. Psychology Humans Hypothyroidism - complications Hypothyroidism - pathology Male Medical sciences Metabolic Diseases - complications Middle Aged Multivariate Analysis Non tumoral diseases. Target tissue resistance. Benign neoplasms Odds Ratio Radiation, Ionizing Regression Analysis Risk Factors Sex Factors Smoking Thyroid. Thyroid axis (diseases) Vertebrates: endocrinology |
| title | Metabolic cardiovascular disease risk factors and their clustering in subclinical hypothyroidism |
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