High Index of Microcirculatory Resistance Level After Successful Primary Percutaneous Coronary Intervention Can Be Improved by Intracoronary Administration of Nicorandil
Background: Although microvascular dysfunction following percutaneous coronary intervention (PCI) can be evaluated with the index of microcirculatory resistance (IMR), no method of treatment has been established. We hypothesized that intracoronary administration of nicorandil can improve IMR after s...
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| Veröffentlicht in: | Circulation Journal 2010, Vol.74(5), pp.909-915 |
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| creator | Ito, Noritoshi Nanto, Shinsuke Doi, Yasuji Sawano, Hirotaka Masuda, Daisaku Yamashita, Shizuya Okada, Ken-ichiro Kaibe, Shoji Hayashi, Yasuyuki Kai, Tatsuro Hayashi, Toru |
| description | Background: Although microvascular dysfunction following percutaneous coronary intervention (PCI) can be evaluated with the index of microcirculatory resistance (IMR), no method of treatment has been established. We hypothesized that intracoronary administration of nicorandil can improve IMR after successful primary PCI in patients with ST-segment elevation myocardial infarction (STEMI). Methods and Results: In 40 patients with first STEMI after successful primary PCI, IMR was measured using PressureWireTM Certus (St. Jude Medical, MN, USA). In 20 of the patients (Group N), IMR was measured at baseline and after intracoronary nicorandil (2 mg/10 ml). In the other 20 patients (Control), IMR was measured at baseline, after intracoronary saline (10 ml) and after intracoronary nicorandil (2 mg/10 ml). In Group N, IMR significantly decreased after intracoronary nicorandil (median IMR, 27.7-18.7 U, P |
| doi_str_mv | 10.1253/circj.CJ-09-0943 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_733954736</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733954736</sourcerecordid><originalsourceid>FETCH-LOGICAL-c493t-17a2a502885957c0e984b151de45c9cc6246d76c690279e8c23b4d24b5726da3</originalsourceid><addsrcrecordid>eNpFkU1P3DAQhq2qVaG0954q33oKdfwRx8dtVGDRFlDL3XKcCXiVONROVuUn8S9xNgtIlm15nnk9My9CX3NymlPBflgX7Pa0usyISouzd-g4Z1xmvKTk_f5eZKrk7Ah9inFLCFVEqI_oiBLKOFHyGD1duLt7vPYN_MdDi387G4ZZderMOIRH_Aeii6PxFvAGdtDhVTtCwH8nayHGdurwTXC9SeQNpKxEwjBFXA1h8PPr2id8B350g8eV8fgn4HX_EIYdNLjex4OxL_Sq6Z1P_wWz51NBVy4FjW9c9xl9aE0X4cvhPEG3Z79uq4tsc32-rlabzHLFxiyXhhpBaFkKJaQlkPqvc5E3wIVV1haUF40sbKEIlQpKS1nNG8prIWnRGHaCvi-yqcZ_E8RR9y5a6LqlMy0ZU4JLViSSLGQaWYwBWv2wjELnRM_26L09urrUROnZnpTy7SA-1T00rwkvfiTgbAG2aeh38AqYMDrbwUFRci3m7U35Dbg3QYNnz1Q0qYY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733954736</pqid></control><display><type>article</type><title>High Index of Microcirculatory Resistance Level After Successful Primary Percutaneous Coronary Intervention Can Be Improved by Intracoronary Administration of Nicorandil</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Ito, Noritoshi ; Nanto, Shinsuke ; Doi, Yasuji ; Sawano, Hirotaka ; Masuda, Daisaku ; Yamashita, Shizuya ; Okada, Ken-ichiro ; Kaibe, Shoji ; Hayashi, Yasuyuki ; Kai, Tatsuro ; Hayashi, Toru</creator><creatorcontrib>Ito, Noritoshi ; Nanto, Shinsuke ; Doi, Yasuji ; Sawano, Hirotaka ; Masuda, Daisaku ; Yamashita, Shizuya ; Okada, Ken-ichiro ; Kaibe, Shoji ; Hayashi, Yasuyuki ; Kai, Tatsuro ; Hayashi, Toru</creatorcontrib><description>Background: Although microvascular dysfunction following percutaneous coronary intervention (PCI) can be evaluated with the index of microcirculatory resistance (IMR), no method of treatment has been established. We hypothesized that intracoronary administration of nicorandil can improve IMR after successful primary PCI in patients with ST-segment elevation myocardial infarction (STEMI). Methods and Results: In 40 patients with first STEMI after successful primary PCI, IMR was measured using PressureWireTM Certus (St. Jude Medical, MN, USA). In 20 of the patients (Group N), IMR was measured at baseline and after intracoronary nicorandil (2 mg/10 ml). In the other 20 patients (Control), IMR was measured at baseline, after intracoronary saline (10 ml) and after intracoronary nicorandil (2 mg/10 ml). In Group N, IMR significantly decreased after intracoronary nicorandil (median IMR, 27.7-18.7 U, P<0.0001). In the Control group, IMR did not change after saline administration (median IMR, 24.3-23.8 U, P=0.8193), but was significantly decreased after intracoronary nicorandil (median IMR, 23.8-14.9 U, P<0.0001). Next, all 40 patients were divided into subgroups by tertile of baseline IMR. In those with intermediate to high IMR (baseline IMR ≥21), intracoronary nicorandil significantly decreased IMR, although it did not change IMR in those with low IMR (baseline IMR <21). Conclusions: High IMR levels in patients with STEMI after successful primary PCI can be improved by intracoronary administration of nicorandil. (Circ J 2010; 74: 909 - 915)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-09-0943</identifier><identifier>PMID: 20234097</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Acute myocardial infarction ; Aged ; Anti-Arrhythmia Agents - administration & dosage ; Catheter Ablation ; Female ; Humans ; Index of microcirculatory resistance ; Male ; Microcirculation ; Microcirculation - drug effects ; Middle Aged ; Myocardial Infarction - physiopathology ; Myocardial Infarction - therapy ; Nicorandil ; Nicorandil - administration & dosage ; Prospective Studies ; Vascular Resistance - drug effects</subject><ispartof>Circulation Journal, 2010, Vol.74(5), pp.909-915</ispartof><rights>2010 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-17a2a502885957c0e984b151de45c9cc6246d76c690279e8c23b4d24b5726da3</citedby><cites>FETCH-LOGICAL-c493t-17a2a502885957c0e984b151de45c9cc6246d76c690279e8c23b4d24b5726da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20234097$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ito, Noritoshi</creatorcontrib><creatorcontrib>Nanto, Shinsuke</creatorcontrib><creatorcontrib>Doi, Yasuji</creatorcontrib><creatorcontrib>Sawano, Hirotaka</creatorcontrib><creatorcontrib>Masuda, Daisaku</creatorcontrib><creatorcontrib>Yamashita, Shizuya</creatorcontrib><creatorcontrib>Okada, Ken-ichiro</creatorcontrib><creatorcontrib>Kaibe, Shoji</creatorcontrib><creatorcontrib>Hayashi, Yasuyuki</creatorcontrib><creatorcontrib>Kai, Tatsuro</creatorcontrib><creatorcontrib>Hayashi, Toru</creatorcontrib><title>High Index of Microcirculatory Resistance Level After Successful Primary Percutaneous Coronary Intervention Can Be Improved by Intracoronary Administration of Nicorandil</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background: Although microvascular dysfunction following percutaneous coronary intervention (PCI) can be evaluated with the index of microcirculatory resistance (IMR), no method of treatment has been established. We hypothesized that intracoronary administration of nicorandil can improve IMR after successful primary PCI in patients with ST-segment elevation myocardial infarction (STEMI). Methods and Results: In 40 patients with first STEMI after successful primary PCI, IMR was measured using PressureWireTM Certus (St. Jude Medical, MN, USA). In 20 of the patients (Group N), IMR was measured at baseline and after intracoronary nicorandil (2 mg/10 ml). In the other 20 patients (Control), IMR was measured at baseline, after intracoronary saline (10 ml) and after intracoronary nicorandil (2 mg/10 ml). In Group N, IMR significantly decreased after intracoronary nicorandil (median IMR, 27.7-18.7 U, P<0.0001). In the Control group, IMR did not change after saline administration (median IMR, 24.3-23.8 U, P=0.8193), but was significantly decreased after intracoronary nicorandil (median IMR, 23.8-14.9 U, P<0.0001). Next, all 40 patients were divided into subgroups by tertile of baseline IMR. In those with intermediate to high IMR (baseline IMR ≥21), intracoronary nicorandil significantly decreased IMR, although it did not change IMR in those with low IMR (baseline IMR <21). Conclusions: High IMR levels in patients with STEMI after successful primary PCI can be improved by intracoronary administration of nicorandil. (Circ J 2010; 74: 909 - 915)</description><subject>Acute myocardial infarction</subject><subject>Aged</subject><subject>Anti-Arrhythmia Agents - administration & dosage</subject><subject>Catheter Ablation</subject><subject>Female</subject><subject>Humans</subject><subject>Index of microcirculatory resistance</subject><subject>Male</subject><subject>Microcirculation</subject><subject>Microcirculation - drug effects</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Infarction - therapy</subject><subject>Nicorandil</subject><subject>Nicorandil - administration & dosage</subject><subject>Prospective Studies</subject><subject>Vascular Resistance - drug effects</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1P3DAQhq2qVaG0954q33oKdfwRx8dtVGDRFlDL3XKcCXiVONROVuUn8S9xNgtIlm15nnk9My9CX3NymlPBflgX7Pa0usyISouzd-g4Z1xmvKTk_f5eZKrk7Ah9inFLCFVEqI_oiBLKOFHyGD1duLt7vPYN_MdDi387G4ZZderMOIRH_Aeii6PxFvAGdtDhVTtCwH8nayHGdurwTXC9SeQNpKxEwjBFXA1h8PPr2id8B350g8eV8fgn4HX_EIYdNLjex4OxL_Sq6Z1P_wWz51NBVy4FjW9c9xl9aE0X4cvhPEG3Z79uq4tsc32-rlabzHLFxiyXhhpBaFkKJaQlkPqvc5E3wIVV1haUF40sbKEIlQpKS1nNG8prIWnRGHaCvi-yqcZ_E8RR9y5a6LqlMy0ZU4JLViSSLGQaWYwBWv2wjELnRM_26L09urrUROnZnpTy7SA-1T00rwkvfiTgbAG2aeh38AqYMDrbwUFRci3m7U35Dbg3QYNnz1Q0qYY</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Ito, Noritoshi</creator><creator>Nanto, Shinsuke</creator><creator>Doi, Yasuji</creator><creator>Sawano, Hirotaka</creator><creator>Masuda, Daisaku</creator><creator>Yamashita, Shizuya</creator><creator>Okada, Ken-ichiro</creator><creator>Kaibe, Shoji</creator><creator>Hayashi, Yasuyuki</creator><creator>Kai, Tatsuro</creator><creator>Hayashi, Toru</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>High Index of Microcirculatory Resistance Level After Successful Primary Percutaneous Coronary Intervention Can Be Improved by Intracoronary Administration of Nicorandil</title><author>Ito, Noritoshi ; Nanto, Shinsuke ; Doi, Yasuji ; Sawano, Hirotaka ; Masuda, Daisaku ; Yamashita, Shizuya ; Okada, Ken-ichiro ; Kaibe, Shoji ; Hayashi, Yasuyuki ; Kai, Tatsuro ; Hayashi, Toru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c493t-17a2a502885957c0e984b151de45c9cc6246d76c690279e8c23b4d24b5726da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acute myocardial infarction</topic><topic>Aged</topic><topic>Anti-Arrhythmia Agents - administration & dosage</topic><topic>Catheter Ablation</topic><topic>Female</topic><topic>Humans</topic><topic>Index of microcirculatory resistance</topic><topic>Male</topic><topic>Microcirculation</topic><topic>Microcirculation - drug effects</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardial Infarction - therapy</topic><topic>Nicorandil</topic><topic>Nicorandil - administration & dosage</topic><topic>Prospective Studies</topic><topic>Vascular Resistance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ito, Noritoshi</creatorcontrib><creatorcontrib>Nanto, Shinsuke</creatorcontrib><creatorcontrib>Doi, Yasuji</creatorcontrib><creatorcontrib>Sawano, Hirotaka</creatorcontrib><creatorcontrib>Masuda, Daisaku</creatorcontrib><creatorcontrib>Yamashita, Shizuya</creatorcontrib><creatorcontrib>Okada, Ken-ichiro</creatorcontrib><creatorcontrib>Kaibe, Shoji</creatorcontrib><creatorcontrib>Hayashi, Yasuyuki</creatorcontrib><creatorcontrib>Kai, Tatsuro</creatorcontrib><creatorcontrib>Hayashi, Toru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ito, Noritoshi</au><au>Nanto, Shinsuke</au><au>Doi, Yasuji</au><au>Sawano, Hirotaka</au><au>Masuda, Daisaku</au><au>Yamashita, Shizuya</au><au>Okada, Ken-ichiro</au><au>Kaibe, Shoji</au><au>Hayashi, Yasuyuki</au><au>Kai, Tatsuro</au><au>Hayashi, Toru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High Index of Microcirculatory Resistance Level After Successful Primary Percutaneous Coronary Intervention Can Be Improved by Intracoronary Administration of Nicorandil</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2010</date><risdate>2010</risdate><volume>74</volume><issue>5</issue><spage>909</spage><epage>915</epage><pages>909-915</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background: Although microvascular dysfunction following percutaneous coronary intervention (PCI) can be evaluated with the index of microcirculatory resistance (IMR), no method of treatment has been established. We hypothesized that intracoronary administration of nicorandil can improve IMR after successful primary PCI in patients with ST-segment elevation myocardial infarction (STEMI). Methods and Results: In 40 patients with first STEMI after successful primary PCI, IMR was measured using PressureWireTM Certus (St. Jude Medical, MN, USA). In 20 of the patients (Group N), IMR was measured at baseline and after intracoronary nicorandil (2 mg/10 ml). In the other 20 patients (Control), IMR was measured at baseline, after intracoronary saline (10 ml) and after intracoronary nicorandil (2 mg/10 ml). In Group N, IMR significantly decreased after intracoronary nicorandil (median IMR, 27.7-18.7 U, P<0.0001). In the Control group, IMR did not change after saline administration (median IMR, 24.3-23.8 U, P=0.8193), but was significantly decreased after intracoronary nicorandil (median IMR, 23.8-14.9 U, P<0.0001). Next, all 40 patients were divided into subgroups by tertile of baseline IMR. In those with intermediate to high IMR (baseline IMR ≥21), intracoronary nicorandil significantly decreased IMR, although it did not change IMR in those with low IMR (baseline IMR <21). Conclusions: High IMR levels in patients with STEMI after successful primary PCI can be improved by intracoronary administration of nicorandil. (Circ J 2010; 74: 909 - 915)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>20234097</pmid><doi>10.1253/circj.CJ-09-0943</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Circulation Journal, 2010, Vol.74(5), pp.909-915 |
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| subjects | Acute myocardial infarction Aged Anti-Arrhythmia Agents - administration & dosage Catheter Ablation Female Humans Index of microcirculatory resistance Male Microcirculation Microcirculation - drug effects Middle Aged Myocardial Infarction - physiopathology Myocardial Infarction - therapy Nicorandil Nicorandil - administration & dosage Prospective Studies Vascular Resistance - drug effects |
| title | High Index of Microcirculatory Resistance Level After Successful Primary Percutaneous Coronary Intervention Can Be Improved by Intracoronary Administration of Nicorandil |
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