Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as indomethacin decrease mucosal PGE 2 content by inhibiting cyclooxygenase (COX) activity and produce damage in the small intestine. The development of intestinal lesions induced by indomethacin was accompanied by increases in intestinal motility,...

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Veröffentlicht in:	Clinica chimica acta 2010-04, Vol.411 (7), p.459-466
Hauptverfasser:	Takeuchi, Koji, Tanaka, Akiko, Kato, Shinichi, Amagase, Kikuko, Satoh, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents, Non-Steroidal - adverse effects COX-1 inhibition COX-2 inhibition Cyclooxygenase Inhibitors - adverse effects Humans Indomethacin - adverse effects Indomethacin - pharmacology Intestinal damage Intestine, Small - drug effects Intestine, Small - enzymology Intestine, Small - pathology Lactones - adverse effects Lactones - pharmacology NSAID Pathogenic mechanism Prostaglandin-Endoperoxide Synthases - metabolism Pyrazoles - adverse effects Pyrazoles - pharmacology Sulfones - adverse effects Sulfones - pharmacology
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